A5088781865- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Pain Mechanisms and Treatments
- Inflammatory Bowel Disease
- Biochemical effects in animals
- Blood properties and coagulation
- Amyotrophic Lateral Sclerosis Research
- Amino Acid Enzymes and Metabolism
- Microscopic Colitis
- Mitochondrial Function and Pathology
- Botulinum Toxin and Related Neurological Disorders
- Neurological Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Neurogenetic and Muscular Disorders Research
- Neurotransmitter Receptor Influence on Behavior
- Gastrointestinal disorders and treatments
- Autoimmune and Inflammatory Disorders
- Parkinson's Disease Mechanisms and Treatments
- Gastric Cancer Management and Outcomes
- Pathogenesis and Treatment of Hiccups
- Helicobacter pylori-related gastroenterology studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Healthcare and Venom Research
Japan Community Healthcare Organization
2021-2024
Kyushu Hospital
2021-2024
Kyushu University
2013-2020
Suwa Red Cross Hospital
2016-2019
Matsuyama Red Cross Hospital
2019
Nippon Steel Yawata Memorial Hospital
2019
Fukuoka University
2016
Sheba Medical Center
2016
Fujita Health University
1993-2013
University of Toyama
2008-2012
The cause of selective degeneration motor neurons in the ventral horn spinal cord associated with amyotrophic lateral sclerosis (ALS) has still not been elucidated. Recently, so-called oxidative stress suggested to be a significant factor pathogenesis this disease. We measured antioxidant actions superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and cytochrome c oxidase (CO) human patients ALS comparison those control patients. Total SOD activity transections from sporadic was...
Abstract —A technique for separating neuronal and glial cell fractions in bulk from rat brain has been developed which does not use any digestive enzymes. Carbonic anhydrase, S‐100 protein 2′,3′‐cyclic nucleotide 3′‐phosphohydrolase were associated with the fraction. Glutamate aspartate most abundant free amino acids; fraction was richer GABA glycine than Both d ‐glutamate potassium ions actively accumulated each during aerobic incubation. Na,K‐ATPase higher fraction; its activity,...
Mesenteric phlebosclerosis (MP) is a disease characterized by fibrotic change or calcification of the mesenteric vein. Recently, there has been an increase in case reports MP related to herbal medicine usage. Long-term intake gardenia fruit (GF) suspected as possible cause. However, many GF users do not develop this and association between remains unclear. In study, we investigated for first time dosage used patients with without MP. We medical chart review study design assess reviewed...
Abstract: The time courses of changes three enolase isozymes (αα, αγ, and γγ), S‐100 protein, 2′,3′‐cyclic nucleotide 3′‐phosphodiesterase (CNPase), ornithine decarboxylase (ODC), β‐galactosidase, glucose‐6‐phosphate dehydrogenase (G6PDH) were examined from 1 to 14 days after cutting the preganglionic nerve (denervation) or postganglionic (axotomy) superior cervical sympathetic ganglion (SCG) rat. wet weight protein content in axotomized SCG increased continuously, nearly twice those...
The concentration of naturally synthesized nerve growth factor (NGF) was measured in various tissues adult rats, using a highly sensitive two-site enzyme immunoassay. highest found the superior cervical sympathetic ganglion (SCG). Transection postganglionic external carotid (ECN) reduced ganglionic level NGF more than did section internal (ICN). When both preganglionic and ECN were cut, decreased even more. On other hand, when ICN sectioned, leaving intact, endogenous content SCG...
We evaluated the effect of keishibukuryogan (KBG; Guizhi-Fuling-Wan), a traditional Japanese (Kampo) formula, on endothelial function assessed by reactive hyperemia peripheral arterial tonometry (Endo-PAT2000) in patients with metabolic syndrome-related factors controlled clinical trial crossover design. Ninety-two were assigned to group A (first KBG-treatment period, then control period; each lasting 4 weeks, about one-year interval) or B control, KBG-treatment). In forty-nine (27, A; 22,...
1. [3H]acetylcholine (ACh) or [3H]gamma‐aminobutyric acid (GABA) was injected into the cell body of a cholinergic neurone Aplysia kurodai. 2. [3H]ACh moved down axon at maximum speed 2.5 mm/sec 20 degrees C. 3. mM‐colchicine suppressed this movement, but some passive movement radioactivity noted along axon. 4. Profiles coincided with theoretically obtained diffusion profiles. 5. The coefficient ACh in axoplasm estimated. It 3 x 10(‐6) cm2/sec 5 C, 4 X 15 C and 6.5 30 Q10 1.35, activation...
To determine whether the response to progestin challenge test can be predicted from endometrial thickness measured sonographically. Progestin tests were performed on 44 women with secondary amenorrhea, each of whom also had her by transvaginal ultrasonography and serum estradiol (E2) levels determined. The relationships between test, thickness, E2 studied, as well presence or absence withdrawal bleeding could levels. endometrium was significantly thicker in 32 who (10.3 ± 4.1 mm) than 12 did...
Rats fed from weaning on semi-purified diets supplemented either with linoleate-rich safflower oil (S) or alpha-linolenate-rich perilla (P) were mated. Half of the progeny weaned to original diet dams (SS and PP), other two groups shifted enriched in fatty acid (SP PS). Brightness-discrimination learning ability was tested daily for 30 d beginning at 11 weeks age, a bright light as positive stimulus. The performance inferior group through generations (SS) compared (PP) which (PS SP)....
Objective Mesenteric phlebosclerosis (MP) is a disease characterized by calcification of the mesenteric vein, which causes chronic ischemia. Recently, long-term intake gardenia fruit ('Sanshishi' in Japanese) has been attracting attention as possible cause. Usually, only advanced, severe MP cases get reported. However, we suspected that some latent this may exist. We performed study order to determine prediagnostic at our outpatient departments herbal (Kampo) medicine, with particular paid...
In post-stroke patients, the recurrence of stroke and progression impairments lead to a bedridden state dementia. As for their treatments, only anti-hypertension anti-coagulation therapies prevent are available. Asia, patients with often treated herbal medicine. The present study evaluated effectiveness tokishakuyakusan (TS) in improving impairment independence patients. Thirty-one (mean age = 81.4 years) were recruited enrolled. Participants randomly assigned TS group (n 16) or...
1) It was thought from the experiments using tracer techniques that γ-aminobutyric acid which added to guinea pig brain slices or rat mitochondria metabolized aerobically through following route; after transaminating α-keto suggested be originated tricarboxylic cycle, succinic semialdehyde produced GAB itself oxidized completely cycle level.2) When uniformly labelled glucose-C14 being in slices, C14 of glucose converted into very actively. The importance aerobic metabolism relation both and...