A5008169301- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Genetics and Neurodevelopmental Disorders
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neurogenesis and neuroplasticity mechanisms
- RNA and protein synthesis mechanisms
- Click Chemistry and Applications
- Synthesis and Reactions of Organic Compounds
- Mast cells and histamine
- Hormonal Regulation and Hypertension
- Neuroscience and Neuropharmacology Research
- Folate and B Vitamins Research
- Neuropeptides and Animal Physiology
- Epigenetics and DNA Methylation
- Autism Spectrum Disorder Research
- Child Nutrition and Feeding Issues
- Infant Health and Development
- Pain Mechanisms and Treatments
- Gut microbiota and health
- Synthesis and Biological Evaluation
- RNA modifications and cancer
Setsunan University
2021-2024
Pharmac
2022
Osaka University
2016
Sumitomo Dainippon Pharma (Japan)
1990
Folate deficiency in a fetus is well known to cause neurodevelopment defects and development disorders. A low level of folate also thought be risk for depression adults. We have previously shown that post-weaning induces neuronal immaturity the dentate gyrus mice, which suggests causes neuropsychological disorders via inhibition maturation. In this study, we examined effects on expression epigenetic modification genes involved differentiation maturation primary mouse neural stem/progenitor...
Abstract The site-specific incorporation of cross-linkable designer amino acids into proteins is useful for covalently bonding protein complexes upon exposure to light. This technology can be used study networks protein-protein interactions in living cells; however, date it has only been applicable use with a narrow range cell types, due the limited availability plasmid-based transfection protocols. In present study, we achieved adenovirus-based expression variant an archaeal pyrrolysyl-tRNA...
Kihito (KIT; Gui Pi Tang) is a traditional herbal medicine that used for treatment of neuropsychiatric disorders such as depression, anxiety, neurosis and insomnia in China Japan. Recently, it has also been shown KIT improves cognitive dysfunction patients with Alzheimer's disease. In this study, to investigate the mechanisms underlying effects on stress-induced brain dysfunctions depressed state memory impairment, we examined whether prevents behavioral neurophysiological abnormalities mice...
Early life stress has a significant impact on development of the central nervous system (CNS), with lasting rather than transient consequences; therefore, it is important to alleviate these effects. In recent years, functional communication between CNS and gut microbiota through so-called brain-gut-microbiota axis been examined, likely that prebiotics contribute microbiota. this study, we performed behavioral, neurohistological, fecal analyses in early-weaned mice examine effects...
The pathogenesis of stress-related disorders involves aberrant glucocorticoid secretion, and decreased pH increased lactate in the brain are common phenotypes several psychiatric disorders. Mice treated with glucocorticoids develop these phenotypes, but it is unclear how affect pH. Therefore, we investigated effect corticosterone (CORT), main rodents, on extracellular release cultured astrocytes, which glial cells that produce brain. CORT treatment for one week level via receptors. also...
Depressed patients may exhibit glucocorticoid hypersecretion, suggesting that elevated levels of glucocorticoids play an important role in the pathophysiology depression. Some postmortem brain studies have shown decreased pH and increased lactate psychiatric patients, implying involvement these factors pathogenesis. To investigate effects on levels, their roles depressive symptoms, were examined mice treated with corticosterone (CORT), major bioactive rodents. A single administration CORT...
We have previously shown that mice exposed to chronic social defeat stress exhibit anxiety-like behavior and decreased serotonin transporter (SERT) expression (5-HT) uptake in the prefrontal cortex (PFC). There is a correlation between these 5-HT uptake, suggesting SERT PFC may induce anxiety. In this study, clarify whether decrease of induces anxiety, we investigated effect knockdown on behavior. Retrograde adeno-associated virus (AAV) vectors producing shRNA against were microinjected into...
Autism spectrum disorder (ASD) is a range of neurodevelopmental conditions generally characterized by impaired social communication and intense interests, these symptoms are observed from early childhood in ASD. Although ASD has strong genetic basis numerous candidate genes have been located, only small effects seem to be attributed any particular gene. Therefore, the involvement environmental (non-genetic) factors development or exacerbation cannot overlooked. Recently, gut microbiota...
Analgesic activity of morphine administered rectally as a suppository was investigated in rats order to ascertain analgesic suppository. Morphine hydrochloride given produced dose-related manner the tail pressure and acetic acid-induced writhing tests, its potency (ED50=about 17 0.689 mg/kg, respectively) approximately twice that orally an aqueous solution. The action durable oral morphine, but onset faster. plasma brain levels reached peak until 30 min after rectal administration...