A5036608548- Alkaloids: synthesis and pharmacology
- Medicinal Plants and Neuroprotection
- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Natural product bioactivities and synthesis
- Neuroscience and Neuropharmacology Research
- Cholinesterase and Neurodegenerative Diseases
- Tryptophan and brain disorders
- Cell death mechanisms and regulation
- Neuroendocrine regulation and behavior
- Bioactive Compounds in Plants
- Phytochemical Studies and Bioactivities
- Autism Spectrum Disorder Research
- GABA and Rice Research
- Phytochemicals and Antioxidant Activities
- Olfactory and Sensory Function Studies
- Fatty Acid Research and Health
- Healthcare and Venom Research
- Microbial Natural Products and Biosynthesis
- Bee Products Chemical Analysis
- Nicotinic Acetylcholine Receptors Study
University of Toyama
2012-2021
IRYO Sosei University
2020
Tohoku University
2004-2017
Chiba University
2005
Hokkaido University
2005
Tohoku Medical and Pharmaceutical University
2001-2004
Article Abstract Objective: This randomized, observer-blind, controlled trial examined the efficacy and safety of traditional Chinese herbal medicine Yi-Gan San (YGS, Yokukan-San in Japanese) improvement behavioral psychological symptoms dementia (BPSD) activities daily living (ADL). Method: Fifty-two patients with mild-to-severe (24 men 28 women, mean ± SD age = 80.3 9.0 years) according to DSM-IV criteria were investigated. Participants randomly assigned YGS group (N 27) or control...
Neurofibrillary tangles (NFTs), neuropil threads, and neuritic elements of senile plaques predominantly comprise hyperphosphorylated tau protein represent pathological characteristics Alzheimer's disease (AD). These lesions occur before the presentation clinical symptoms correlate with severity dementia. In vivo detection these would thus prove useful for preclinical diagnosis AD tracking progression. The present study introduces three novel compounds, 4-[2-(2-benzoimidazolyl)ethenyl]- N ,...
Because the deposition of β-amyloid protein (Aβ) is a consistent pathological hallmark Alzheimer's disease (AD) brains, inhibition Aβ generation, prevention fibril formation, or destabilization preformed fibrils would be attractive therapeutic strategies for treatment AD. We examined effects several medicinal herbs used in traditional Chinese medical formulae on formation and by using thioflavin T binding assay, atomic force microscopic imaging, electrophoresis. Our study demonstrates that...
Abstract The deposition of amyloid β (Aβ) protein is a consistent pathological hallmark Alzheimer’s disease (AD) brains; therefore, inhibition Aβ fibril formation and destabilization pre‐formed fibrils an attractive therapeutic preventive strategy in the development disease‐modifying drugs for AD. This study demonstrated that Paeonia suffruticosa , traditional medicinal herb, not only inhibited both 1–40 1–42 but it also destabilized concentration‐dependent manner. Memory function was...
Aside from accumulation of amyloid-β (Aβ) peptide in the brain, Alzheimer's disease (AD) has been reported as being associated with peroxidation major phospholipids (e.g., phosphatidylcholine (PtdCho)) and degradation antioxidative ethanolamine plasmalogen (PlsEtn)). In addition to its presence Aβ is also found blood; however, there still little information about levels PtdCho hydroperoxide (PCOOH) PlsEtn blood patients AD. this study, by assuming a possible interaction among Aβ, PCOOH,...
A new cytotoxic compound, brasilibactin (1), has been isolated from the actinomycete Nocardia brasiliensis IFM 0995, and structure was elucidated on basis of spectroscopic data chemical means.
We have previously reported that dietary docosahexaenoic acid (DHA) improves and/or protects against impairment of cognition ability in amyloid beta(1-40) (Abeta(1-40))-infused Alzheimer's disease (AD)-model rats. Here, after the administration DHA to AD model rats for 12 weeks, levels Abeta(1-40), cholesterol and composition fatty acids were investigated Triton X100-insoluble membrane fractions their cerebral cortex. The effects on vitro formation kinetics fibrillation Abeta(1-40) also by...
Daily treatment of ovariectomized (OVX) ICR mice with puerarin, a glycosyl isoflavone isolated from the root bark Pueraria candollei var. mirifica, and 17β-estradiol attenuated ovariectomy-induced depression-like behavior, as indicated by decrease in immobility times tail suspension test (TST) forced swimming (FST), an increase uterine weight volume, serum corticosterone levels, dose-dependently normalized downregulated transcription brain-derived neurotrophic factor (BDNF) estrogen receptor...
We previously demonstrated that Bacopa monnier (L.) WETTST. extract (BME) ameliorated cognitive dysfunction in animal models of dementia by enhancing synaptic plasticity-related signaling the hippocampus and protecting cholinergic neurons medial septum. To further clarify pharmacological features availability BME as a novel anti-dementia agent, we investigated whether affects neuronal repair using mouse model trimethyltin (TMT)-induced loss/self-repair hippocampus. Mice pretreated with TMT...
We isolated ophiobolin A from the f-7438 fungus strain. In L1210 cell line, (0-01-1 μM) showed cytotoxicity in a concentration-dependent manner. Morphological observations revealed that (1 induced shrinkage soma and chromatin condensation, suggesting apoptotic death. Moreover, DNA gel electrophoretic experiments, typical ladder pattern was observed after treatment with this compound. The flow cytometric experiment indicated (0.01-1 caused apoptosis close agreement concentrations...