A5001682320- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- Eicosanoids and Hypertension Pharmacology
- Circadian rhythm and melatonin
- Biochemical effects in animals
- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
- Birth, Development, and Health
- Neurological Disease Mechanisms and Treatments
- Advanced Glycation End Products research
- Thermoregulation and physiological responses
- Per- and polyfluoroalkyl substances research
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Neuroprotection
- Stress Responses and Cortisol
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Dietary Effects on Health
- Tea Polyphenols and Effects
- Diet and metabolism studies
- Exercise and Physiological Responses
- Ginger and Zingiberaceae research
- Biochemical Analysis and Sensing Techniques
Josai University
2016-2025
Shimane University
2012-2021
Faculty (United Kingdom)
2015
National Institutes of Health
2013
Kyushu University of Health and Welfare
2011
Nippon Suisan Kaisha (Japan)
2011
Docosahexaenoic acid (DHA) has been shown to promote neuronal differentiation of neural stem cells (NSCs) in vivo and vitro. Previously, we found that N-docosahexaenoylethanolamine (synaptamide), an endogenous DHA metabolite with endocannabinoid-like structure, promotes neurite growth, synaptogenesis, synaptic function. In this study, demonstrate synaptamide potently induces NSCs. Differentiating NSCs were capable synthesizing from DHA. Treatment at low nanomolar concentrations significantly...
Polyunsaturated fatty acids (PUFAs) can induce neurogenesis and recovery from brain diseases. However, the exact mechanisms of beneficial effects PUFAs have not been conclusively described. We recently reported that docosahexaenoic acid (DHA) induced neuronal differentiation by decreasing Hes1 expression increasing<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Aim We examined the effects of administration docosahexaenoic acid ( DHA )‐enriched meals on cognitive function in oldest elderly with impairment, such as dementia, living nursing homes, and improvement caregiver burden at aging agencies. Methods Participants care facilities homes n = 75; 88.5 ± 0.6 years) were randomized active placebo groups. The group had family‐style containing an additional 1720 mg per day for 12 months. At baseline, after 6 months intervention, was assessed using H...
Previous research has shown that habitual chocolate intake is related to cognitive performance and frequent consumption significantly associated with improved memory. However, little known about the effects of subchronic dark (DC) on function neurotrophins. Eighteen healthy young subjects (both sexes; 20–31 years old) were randomly divided into two groups: a DC group (n = 10) cacao-free white (WC) 8). The then consumed daily for 30 days. Blood samples taken measure plasma levels theobromine...
Modern dietary trends have led to an increase in foods that are relatively high n-6 polyunsaturated fatty acids (PUFAs) and low n-3 PUFAs. We previously reported the offspring of mother mice consumed a diet linoleic acid (LA) α-linolenic (ALA), hereinafter called LA
We have previously reported that dietary docosahexaenoic acid (DHA) improves and/or protects against impairment of cognition ability in amyloid beta(1-40) (Abeta(1-40))-infused Alzheimer's disease (AD)-model rats. Here, after the administration DHA to AD model rats for 12 weeks, levels Abeta(1-40), cholesterol and composition fatty acids were investigated Triton X100-insoluble membrane fractions their cerebral cortex. The effects on vitro formation kinetics fibrillation Abeta(1-40) also by...
The mechanism of the effect docosahexaenoic acid (DHA; C22:6, n-3), one essential brain nutrients, on in vitro fibrillation amyloid beta (Abeta(1-42)), Abeta(1-42)-oligomers and its toxicity imparted to SH-S5Y5 cells was studied with use thioflavin T fluorospectroscopy, laser confocal microfluorescence, transmission electron microscopy. results clearly indicated that DHA inhibited Abeta(1-42)-fibrill formation a concomitant reduction levels soluble Abeta(1-42) oligomers. polymerization (into...
Theobromine (TB) is a primary methylxanthine found in cacao beans. cAMP-response element-binding protein (CREB) transcription factor, which involved different brain processes that bring about cellular changes response to discrete sets of instructions, including the induction brain-derived neurotropic factor (BDNF). Ca2+/calmodulin-dependent kinase II (CaMKII) has been strongly implicated memory formation species as key regulator gene expression. Here we investigated whether TB acts on...
The mechanism by which perfluorooctanoic acid (PFOA) is transported in the kidney was studied rats. We hypothesized that some transporters are expressed basolateral and/or brush border membrane of proximal tubular cells mediate transport PFOA. Mannitol infusion, caused an increase urine flow rate, significantly increased renal clearance (CLR) PFOA both male and female Feeding a low-phosphate diet causes expression rat type II sodium-dependent phosphate transporter (Npt2) reduced CLR These...
Identifying agents that inhibit amyloid beta peptide (Aβ) aggregation is the ultimate goal for slowing Alzheimer's disease (AD) progression. This study investigated whether glycoside asiaticoside inhibits Aβ1-42 fibrillation in vitro.Fluorescence correlation spectroscopy (FCS), evaluating Brownian diffusion times of moving particles a small confocal volume at single-molecule level, was used. If early steps, more Aβs would remain free and rapidly diffuse volume. In contrast, "weaker or no...
Heat acclimation in rats is associated with enhanced neurogenesis thermoregulatory centers of the hypothalamus. To elucidate mechanisms for heat acclimation, we investigated effects direct mild exposure on proliferation and differentiation neural stem/progenitor cells (NSCs/NPCs). The NSCs/NPCs isolated from forebrain cortices 14.5-day-old rat fetuses were propagated as neurospheres at either 37.0°C (control) or 38.5°C (mild exposure) four days, by MTS cell viability assay, measurement...
Abstract Some clinical trials showed that omega-3 fatty acid (FA) reduced cardiovascular events, but it remains unknown whether FA supplementation changes the composition of FAs and their metabolites in heart how changes, if any, exert beneficial effects on cardiac structure function. To clarify these issues, we supplied to mice exposed pressure overload, examined function by echocardiography a proportion gas chromatography liquid chromatography-tandem mass spectrometry, respectively....
Oxidized low-density lipoprotein (Ox-LDL) is known to be highly atherogenic. Thus, decreasing the blood levels of Ox-LDL through dietary means an important approach reduce cardiovascular events in high-risk individuals. In this randomized placebo-controlled human interventional trial, we aimed evaluate whether Perilla frutescens leaf powder (PLP) ameliorates and home pressure, along with its biological antioxidant potential. Healthy Japanese volunteers aged 30–60 years (n = 60) were PLP...
The omega-3 polyunsaturated fatty acids (ω-3 PUFAs) docosahexaenoic acid (DHA) and/or eicosapentaenoic (EPA) protect against diabetic nephropathy by inhibiting inflammation. aim of this study was to assess the effects highly purified DHA and EPA or only administration on renal function eicosanoid docosanoid levels in an animal model metabolic syndrome, SHR.Cg-Leprcp/NDmcr (SHRcp) rats. Male SHRcp rats were divided into 3 groups. Control (5% arabic gum), TAK-085 (300 mg/kg/day, containing 467...