A5103082005- Health Systems, Economic Evaluations, Quality of Life
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Ion channel regulation and function
- Coordination Chemistry and Organometallics
- Liver Disease and Transplantation
- Chemical Synthesis and Reactions
- Nitric Oxide and Endothelin Effects
- Asymmetric Hydrogenation and Catalysis
- Marine Biology and Environmental Chemistry
- Inorganic Chemistry and Materials
- Synthesis and characterization of novel inorganic/organometallic compounds
- Pain Mechanisms and Treatments
- Cardiac electrophysiology and arrhythmias
- Alzheimer's disease research and treatments
- Chemical Synthesis and Characterization
- Ammonia Synthesis and Nitrogen Reduction
- Neuroscience and Neuropharmacology Research
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Pharmacy and Medical Practices
- Microwave-Assisted Synthesis and Applications
- Delphi Technique in Research
- Clinical Nutrition and Gastroenterology
- Marine Toxins and Detection Methods
Okayama University of Science
2019-2025
University of Shizuoka
2014-2025
Okayama University
2015-2024
Pharmac
2019-2023
Graco (United States)
2023
Okayama University Hospital
2021
Tohoku University
1999-2019
Tochigi Cancer Center
2016-2019
Graduate School USA
1987-2017
RMIT University
2015
The purpose of this study was to measure the population norms for Japanese versions preference-based measures (EQ-5D-3L, EQ-5D-5L, and SF-6D). We also considered relations between QOL score in general socio-demographic factors. A total 1143 adult respondents (aged ≥ 20 years) were randomly sampled from across Japan using data Basic Resident Register. health status each respondent measured EQ-5D-3L, SF-6D, responses regarding as well subjective diseases symptoms obtained. converted a value...
The valuation study of the five-level version EuroQol five-dimensional questionnaire (EQ-5D-5L) involved composite time trade-off (cTTO) and a discrete choice experiment (DCE). DCE scores must be anchored to quality-of-life scale from 0 (death) 1 (full health). Nevertheless, characteristics statistical methods used for converting EQ-5D-5L results by using TTO information are not yet clearly known.To present Japanese value set compare three latent values.The survey sampled general population...
Abstract β‐Secretase β‐site APP cleaving enzyme 1 (BACE1), is a membrane‐bound aspartyl protease necessary for the generation of amyloid β‐protein (Aβ), which accumulates in brains individuals with Alzheimer's disease (AD). To gain insight into mechanisms by BACE1 activity regulated, we used proteomic methods to search BACE1‐interacting proteins human neuroblastoma SH‐SY5Y cells, overexpress BACE1. We identified reticulon 4‐B (RTN4‐B; Nogo‐B) as BACE1‐associated membrane protein....
Background The concept of career identity is integral to nursing practices and forms the basis professions. Positive essential for providing high-quality care, optimizing patient outcomes, enhancing retention health professionals. Therefore, there a need explore potential influencing variables, thereby developing effective interventions improve identity. Objectives To investigate relationship between moral distress, courage, identity, mediating role courage distress among nurses. Design A...
Owing to the ongoing global mental health crisis, providing support for employees returning work after a leave has become crucial issue. This study aimed preliminarily examine efficacy of functional assertiveness training program incorporating acceptance and commitment therapy (ACT) in pilot involving individuals who had taken absence due problems. As part program, eight group sessions were offered these format while they attended an outpatient psychiatric clinic. The effectiveness was...
Junctional membrane complexes (JMCs) composed of the plasma and endoplasmic/sarcoplasmic reticulum seem to be a structural platform for channel crosstalk. Junctophilins (JPs) contribute JMC formation by spanning sarcoplasmic binding with in muscle cells. In this article, we report that mutant JP double-knockout (JP-DKO) mice lacking neural subtypes exhibited an irregular hindlimb reflex impaired memory. Electrophysiological experiments indicated activation small-conductance Ca(2+)-activated...
By DNA cloning, we have identified the BSRP (brain‐specific receptor‐like proteins) family of three members in mammalian genomes. BSRPs were predominantly expressed soma and dendrites neurons localized endoplasmic reticulum (ER). Expression levels seemed to fluctuate greatly during postnatal cerebellar maturation. Triple‐knockout mice lacking exhibited motor discoordination, Purkinje cells (PCs) often innervated by multiple climbing fibers with different neuronal origins mutant cerebellum....
Hot metal dephosphorization slags in the BOF can be considered to within CaO–SiO2–FeO–P2O5 system, and are usually dicalcium silicate (C2S) saturated composition range. It is well known that C2S forms a pseudo-binary solid solution with tricalcium phosphate (C3P) over wide range at treatment temperature. To increase reaction efficiency of dephosphorization, it important mass transfer rate P2O5 from liquid slag solution.In order clarify mechanism between slag, an artificially made C2S–C3P rod...
Aplyronine A is a macrolide isolated from Aplysia kurodai. By monitoring fluorescent intensity of pyrenyl-actin, it was found that aplyronine inhibited both the velocity and degree actin polymerization. also quickly depolymerized F-actln. The kinetics depolymerizatlon suggest severs F-actin. relationship between concentration total F-actin at different concentrations suggests forms 1:1 complex with G-actin. From these results, concluded inhibits polymerization depolymerizes by nibbling....
We compared the effects of dimeric marine toxins, bistheonellide A, and swinholide on actin polymerization. Bistheonellide A possess two identical side chains with similar structures to those other mycalolide B, aplyronine A. By monitoring changes in fluorescent intensity pyrenyl-actin, was found inhibit polymerization G-actin depolymerize F-actin a concentration-dependent manner. The relationship between concentration its inhibitory activity suggested that one molecule binds molecules...
A toxin isolated from marine sponge, mycalolide‐B, inhibited smooth muscle contractions without changing cytosolic Ca 2+ levels. It also ‐induced contraction in permeabilized muscles. In native actomyosin prepared chicken gizzard, mycalolide‐B superprecipitation and Mg ‐ATPase activity stimulated by myosin light chain phosphorylation. the preparation thiophosphorylated with ATPγS, ATP‐induced activity, respectively, absence of . Mycalolide‐B skeletal actomyosin. had no effect on...
The introduction of UW solution into clinical transplantation has permitted extended cold storage preservation the liver. Over a 46-month period, we have performed 308 orthotopic liver transplants (268 primary, 42 retransplants) in 266 recipients. Our experience is divided cold-storage Eurocollins (163 140 recipients) and (145 131 solutions. Donor recipient factors were comparable between two groups. use an increase mean time from 5.2±1.0 [EC] to 12.8±4.3 [UW] hr (P<0.001). total operating...
We investigated the mode of relaxant effects cytochalasin D, a capping agent actin filaments, on contractile responses in rat aorta and chicken gizzard smooth muscles. Cytochalasin D inhibited contraction induced by high K+ or noradrenaline (10 nM-1 microM) without changing cytosolic Ca2+ level ([Ca2+]i) aorta. In absence external Ca2+, 12-deoxyphorbol 13-isobutylate (DPB) (1 sustained increasing [Ca2+]i also this contraction. permeabilized muscle, (1-10 microM)-induced Ca(2+)-independent...
The yeast reporter assay has been widely used in various applications such as detection of endocrine disruptors and analysis protein−protein interactions by the two-hybrid system. molecular characteristics enzyme are critical determinants for this assay. We herein report establishment a novel using secretory luciferase, Cypridina noctiluca luciferase (CLuc), an alternative to conventional β-galactosidase. CLuc is more sensitive convenient than A high-throughput was established with...
An actin-depolymerizing marine natural product, mycalolide B, and a related compound, kabiramide D, were labeled with biocytin, biotin derivative, used to specify target molecules in cultured rat 3Y1 fibroblasts. Mycalolide B exhibited the ability bind various intracellular proteins, probably through Michael addition of sulfhydryl group C5 B. However, no proteins other than actin apparently reacted biocytinylated demonstrating that binding D was highly specific. Cells treated followed by...
Accumulated studies have shown that ω-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) protective roles against inflammatory responses hyperlipidemia, diabetes mellitus (DM) and cardiovascular diseases. Here we examined the effects of administering EPA to hyperlipidemic patients other undergoing cardiac surgery determine whether this treatment would increase plasma levels clarify association between adiponectin production in patients. We also assessed effect preoperative...