A5028877477- Foot and Ankle Surgery
- Orthopedic Surgery and Rehabilitation
- Knee injuries and reconstruction techniques
- Tendon Structure and Treatment
- Lower Extremity Biomechanics and Pathologies
- Bone fractures and treatments
- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Shape Memory Alloy Transformations
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Orthopaedic implants and arthroplasty
- Musculoskeletal Disorders and Rehabilitation
- Renal and related cancers
- Nuclear Receptors and Signaling
- Muscle activation and electromyography studies
- Balance, Gait, and Falls Prevention
- Shoulder Injury and Treatment
- Sperm and Testicular Function
- Genetics and Neurodevelopmental Disorders
- Pancreatic function and diabetes
- Chronic Kidney Disease and Diabetes
- Metabolism, Diabetes, and Cancer
- Ubiquitin and proteasome pathways
Social Insurance Saitama Chuo Hospital
2019-2024
Dokkyo Medical University Saitama Medical Center
2013-2024
Nippon Veterinary and Life Science University
2014-2024
Dokkyo Medical University
2019-2021
National Institute of Advanced Industrial Science and Technology
2010-2014
University of Iowa
2004-2013
Iowa City Public Library
2004-2012
Louisiana State University Health Sciences Center New Orleans
2007-2011
University of Iowa Hospitals and Clinics
2006-2011
Stryker (United States)
2008
Excessive joint surface loadings, either single (acute impact event) or repetitive (cumulative contact stress), can cause the clinical syndrome of osteoarthritis (OA). Despite advances in treatment injured joints, risk OA following injuries has not decreased past 50 years. Cumulative excessive articular stress that leads to results from posttraumatic incongruity and instability, dysplasia, but may also patients without known abnormalities. In vitro investigations show cartilage loading...
Despite the best current treatments, intra-articular fractures commonly cause posttraumatic osteoarthritis. In this disorder, death and dysfunction of chondrocytes associated with acute cartilage injury presumably plays an important role in triggering pathomechanical cascade that eventually leads to whole-joint degeneration. Information regarding cell-level injury, particularly at whole-organ level actual human joints, has been lacking. study, distribution progression fracture-associated...
Abstract Instability is a significant concern in total hip arthroplasty (THA), particularly when there structural compromise of the capsule due to pre‐existing pathology or necessities surgical approach. An experimentally grounded fiber‐direction‐based finite element model was developed, and integrated with an established three‐dimensional impingement/dislocation. Model validity by close similarity results from cadaveric experiment servohydraulic simulator. Parametric computational runs...
Background Recently, osteochondral grafting has become a popular procedure for treating challenging talar dome lesions. However, no guidelines exist selection of the surgical approach to obtain perpendicular access dome. Hypothesis The majority can be accessed resurfacing procedures without need osteotomy. Study Design Descriptive laboratory study. Methods Nine human cadaveric ankles were dissected in standard fashion expose Seven approaches used, including 4 arthrotomies (anteromedial,...
Background: In ankles with end-stage osteoarthritis or total ankle replacement (TAR), radiographic landmarks based on joint surface morphology usually are obscured and inadequate for measurement. Furthermore, because of difficulty in reproducibly positioning the a standing radiograph, any measure to accurately describe alignment must tolerate perturbations clinical radiographs. To identify anteroposterior tibial-talar that meets those requirements, three methods were compared determine their...
Passive ankle stability under weight-bearing conditions has been found to depend substantially on the role of articular surface geometry. In present study, it was hypothesized that, in axial loading, contact-stress changes response alterations external load involve reproducible and specific patterns maintain stability.Six cadaver ankles with peri-ankle ligaments intact were tested. Each specimen, held at several predetermined positions a primary one-body-weight force, subjected an additional...
Background: Joint instability has long been empirically recognized as a leading risk factor for osteoarthritis. However, formal mechanistic linkage of to osteoarthritis development not established. This study aimed support clinically accepted, but heretofore scientifically unproven, concept that the severity and rapidity in unstable joints is dependent on degree instability. In survival rabbit knee model graded joint instability, relationship between magnitude intensity cartilage...
Abstract Disease‐related and senescent decrease of physiological variability in biological time‐series outputs (e.g., heart rate) has drawn increasing attention as a potential new type biomarker. In this paradigm, measurement periodic motion may enable quantitative evaluation functional limitation people with musculoskeletal disorders. A novel technique to measure leg patterns during level walking was used study 52 adults symptomatic knee osteoarthritis (OA), 57 asymptomatic control subjects...
Injury of the interosseous talocalcaneal ligament (ITCL) has been recognized as a cause subtalar instability, though lack an accepted clinical test limited ability clinicians to reliably make diagnosis. Clinical effects ITCL failure remain unclear because insufficient understanding role ligament.Load-displacement characteristics joint were studied in six cadaver specimens using axial distraction and transverse multi-direction drawer test. In all tests, cyclic loading (+/-60 N) was applied,...
When performing the Scandinavian Total Ankle Replacement (STAR), positioning of talar component and selection mobile-bearing thickness are critical. A biomechanical experiment was undertaken to establish effects these variables on range movement (ROM) ankle. Six cadaver ankles containing a specially-modified STAR prosthesis were subjected ROM determination, under weight-bearing conditions, while monitoring strain in peri-ankle ligaments. Each specimen tested with positions neutral, as well 3...
Background: In ankles with end-stage osteoarthritis or after total ankle replacement (TAR), radiographic landmarks based on joint surface morphology usually are obscured and inadequate for measurement. Two methods quantifying anteroposterior tibial-talar alignment without relying those were identified in a corollary cadaver-based study. This study aimed to verify reliability validity of candidate measures. Methods: On clinical radiographs 33 nonarthritic 35 arthritic ankles, the was...
In the Agility total ankle replacement system, motion is constrained by implant's articulating surfaces and peri-ankle ligaments. The effects of plausibly occurring implant malpositioning on ligament functional extension during walking were explored in this study. intent was to determine whether certain ligaments could serve as guides assist proper component positioning at implantation. Using a cadaver preparation with simulated physiologic loading, we monitored change length anterior...
Background: Talar osteochondral defects can lead to joint degeneration. Focal resurfacing with a metallic implant has shown promise in other joints. We studied the effect of implantation accuracy on ankle contact mechanics after focal defect talar dome. Methods: Static loading seven cadaver ankles was performed before and creation 15-mm-diameter dome, stresses were measured. The then resurfaced implant, use custom implant-bone interface fixture that allowed fine control (in 0.25-mm steps)...
ABSTRACT Medial meniscus destabilization (MMD) is a surgical insult technique for modeling osteoarthritis (OA) by replicating chronic abnormal cartilage loading in animal joints vivo. The present study aimed to characterize the immediate biomechanical effects (ex vivo) and short‐term histological consequences (in of MMD rabbit knee. In compressive test, contact stress distribution medial compartment was measured eight cadaver knees, initially with all major joint structures uninjured...
External rotation stress is used intraoperatively for diagnosing medial ankle and syndesmotic instability in rotational fractures after reduction fixation of the fibula. However, external includes hindfoot, midfoot, motion. The purpose this study was to determine effect hindfoot positioning when using test. Isolated deep deltoid ligament (DDL) combined DDL were modeled. An intact fibula as a surrogate an anatomically fixed fracture.Six cadaver specimens with full-length tib-fib articulations...
The goals of this work were to characterize progression osteoarthritic cartilage degeneration in a rabbit medial meniscus destabilization (MMD) model and then use the identify pre-histologic disruptions chondrocyte metabolism under chronically elevated joint contact stresses vivo. To PTOA progression, 24 rabbits received either MMD or sham surgery. Limb loading was analyzed preoperatively at regular postoperative intervals using Tekscan pressure-sensitive walkway. Animals euthanized 8 (n =...
Mutations in the WWOX gene cause a broad range of ultra-rare neurodevelopmental and brain degenerative disorders, associated with high likelihood premature death animal models as well humans. The encoded Wwox protein is WW domain-containing oxidoreductase that participates crucial biological processes including tumor suppression, cell growth/differentiation regulation steroid metabolism, while its role neural development less understood. We analyzed exomes family affected multiple pre-...
This study was undertaken to compare the clinical and magnetic resonance imaging results of 24 patients who had sustained ligament injuries after acute inversion injury ankle. On imaging, following lesions were detected: anterior talofibular tear in 23 patients, calcaneofibular lesion 15, posterior 11, interosseous talocalcaneal 13, cervical 12, deltoid 8. Compared with outcome at follow-up study, there a statistically significant relationship between each giving way, pain, limitation ankle...