A5088501475- Pharmacogenetics and Drug Metabolism
- Estrogen and related hormone effects
- Nerve injury and regeneration
- Drug Transport and Resistance Mechanisms
- Bioactive Compounds in Plants
- Bioactive natural compounds
- Neuropeptides and Animal Physiology
- Mycotoxins in Agriculture and Food
- Cholesterol and Lipid Metabolism
- Plant Disease Resistance and Genetics
- Phytochemicals and Antioxidant Activities
- RNA Interference and Gene Delivery
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Receptor Mechanisms and Signaling
- Cancer Cells and Metastasis
- Peroxisome Proliferator-Activated Receptors
- Rice Cultivation and Yield Improvement
- Genetic Mapping and Diversity in Plants and Animals
- Virus-based gene therapy research
- Signaling Pathways in Disease
- Adipose Tissue and Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Natural product bioactivities and synthesis
- Medicinal Plants and Neuroprotection
Toho University
2015-2024
University of Shizuoka
2003-2015
Khon Kaen University
2009
Chulalongkorn University
2009
The University of Tokyo
1998-2006
Institute of Agrobiological Sciences
2005
Tokyo University of Science
1986-1998
University of Vermont
1998
Haibara General Hospital
1996
Fujitsu (Japan)
1994
In this communication, we demonstrate the sequential expression of endogenous molecules, including immediate early genes (IEGs), cytokines, neurotrophins, and neurotrophin receptors in injured spinal cord. acute phase, IEGs cytokines mRNAs were rapidly upregulated within 1 h nonneuronal cells lesioned sites surrounding white gray matter. Maximal was observed at for c-fos TNF-alpha mRNAs, 3 c-jun IL-6 6 IL-1 beta mRNA, these signals virtually nondetectable after 6–12 from onset injury. Some...
One of the major serotonin (5-HT) receptor subtypes expressed in rat dorsal root ganglion (DRG) neurons is 5-HT2A receptor. We have previously shown that receptors peripheral sensory terminals are responsible for 5-HT-induced pain and hyperalgesia. In present study, we characterized expressing DRG by means situ hybridization, immunohistochemistry, reverse transcription-polymerase chain reaction (RT-PCR) behavioral tests. hybridization on consecutive sections revealed mRNA colocalized with...
From the heartwood of Dalbergia parviflora, eight new compounds, khrinones A (1), B (2), C (3), D (4), and E (5), isodarparvinol (6), dalparvin (7), (3S)-sativanone (22), along with 32 known have been isolated characterized as 17 isoflavones, nine isoflavanones, five flavanones, six isoflavans, three miscellaneous substances. Isolates were evaluated for their cell proliferation stimulatory activity against MCF-7 T47D human breast cancer lines, luciferase inductive effects using transiently...
A 9-kilobase-pair clone containing a myc-related gene that we have designated s-myc was isolated from rat genomic library. The entire nucleotide sequence of the cloned DNA determined, showing contains an open reading frame consisting 1287 base pairs without introns. In vitro transcription-translation analysis indicated this produces protein approximately 50 kDa. amino acid predicted showed s-Myc is closely related to murine N-Myc but lacks acidic acid-rich commonly present in Myc-family...
Abstract The mass of a root is determined by two underlying morphogenetic factors: (1) the length main axis (root length: RAL), and (2) amount lateral development generated unit (branching index: BI). rice adventitious was partitioned into these factors at quantitative trait locus (QTL) level, using ‘Akihikari’ (a lowland cultivar as recurrent parent) × ‘IRAT 109’ (an upland cultivar) backcross inbred lines. Four QTLs were detected for dry weight individual roots weight: RDW), which...
While searching for new estrogenic compounds from the plant kingdom, we investigated an extract of seeds Cuscuta chinensis (Convolvulaceae) which showed potency stimulating MCF-7 cell proliferation. A novel resin glycoside, cuscutic resinoside (6) was isolated along with five known extract. The structure deduced its spectral data as (11S)-hydroxyhexadecanoic acid 11-O-α-L-(4-O-2R,3R-nilylrhamnopyranosyl)-(1→2)-O-α-L-rhamnopyranosyl-(1,2-lactone) forming a unique 15-membered macrocyclic...
We had previously reported that treatment with the aryl hydrocarbon receptor (AHR) agonist β-naphthoflavone (βNF) suppressed mammosphere formation derived from cancer stem cells in human breast MCF-7 (Cancer Lett., 317, 2012, Zhao et al.). Here, using several AHR agonists, we have investigated association of this suppression classical ability to induce AHR-mediated gene transcription xenobiotic response element (XRE). The assays were performed wild-type and AHR-knockout presence agonists...
Recently, growing evidence of the pivotal roles peroxisome proliferator-activated receptor (PPAR) β/δ in various physiological functions, including lipid homeostasis, cancer, and inflammation, has raised interest this receptor. In study, naturally occurring dimeric alkaloid picrasidine N (1) from Picrasma quassioides was identified as a novel PPARβ/δ agonist library consisting plant extracts natural compounds using mammalian one-hybrid assay, compound characterized. Compound 1 activated but...
Picrasidine C (1), a dimeric β-carboline-type alkaloid isolated from the root of Picrasma quassioides, was identified to have PPARα agonistic activity by mammalian one-hybrid assay compound library. Among PPAR subtypes, 1 selectively activated in concentration-dependent manner. Remarkably, also promoted transcriptional peroxisome proliferator response element-driven luciferase reporter assay. Furthermore, induced expression PPARα-regulated genes involved lipid, glucose, and cholesterol...