A5034823025- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- Reproductive Biology and Fertility
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- Global Maternal and Child Health
- Health Systems, Economic Evaluations, Quality of Life
- Reproductive Physiology in Livestock
- Microbial infections and disease research
- Blood Coagulation and Thrombosis Mechanisms
- Sperm and Testicular Function
- Cardiac Health and Mental Health
- Animal Behavior and Welfare Studies
- Protease and Inhibitor Mechanisms
- Animal Nutrition and Physiology
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- Animal Virus Infections Studies
- Malaria Research and Control
- Plant and fungal interactions
- Ear Surgery and Otitis Media
- Pharmacological Effects and Assays
- Bacterial Infections and Vaccines
Imelda Hospital
2015-2024
Deloitte (United States)
2009-2011
Veterinary and Agrochemical Research Centre
1999-2002
KU Leuven
1997
The University of Texas Southwestern Medical Center
1997
Vlaams Instituut voor Biotechnologie
1995-1997
Cleveland Clinic
1995
Ghent University
1992-1994
Background Circumstantial evidence suggests that the plasminogen/plasmin system plays a role in many biological processes, including hemostasis, cell migration, and development. Methods Results The vivo function of was studied by generation plasminogen-deficient ( Plg −/− ) mice. Inactivation murine plasminogen gene achieved replacing, via homologous recombination embryonic stem cells, genomic sequences encoding exons containing catalytic site amino acids His 605 Asp 648 with neomycin...
BackgroundInternational research indicates that attendance of patients to a proposed cardiac rehabilitation (CR) programme varies between 21% and 75%. Addressing the reasons why are not participating will improve accessibility CR. The objective this study was investigate patient compliance with refusing or abandoning programme.
To estimate the potential cost-effectiveness of quadrivalent influenza vaccine compared with trivalent in UK.A lifetime, multi-cohort, static Markov model was constructed, nine age groups each divided into healthy and at-risk categories. Influenza A B were accounted for separately. The run one-year cycles a lifetime (maximum age: 100 years). analysis from perspective UK National Health Service. Costs benefits discounted at 3.5%. 2010 vaccination policy (vaccination people risk those aged ≥65...
Seasonal influenza infection is primarily caused by circulation of two A strain subtypes and strains from B lineages that vary each year. Trivalent vaccine (TIV) contains only one the B-lineage strains, resulting in mismatches between predominant circulating lineage. Quadrivalent (QIV) includes both strains. The objective was to estimate cost-utility introducing QIV replace TIV Germany.An individual-based dynamic transmission model (4Flu) using German data used provide realistic estimates...
An existing model was used to identify key drivers of profitability and estimate the impact on environmental sustainability when immunizing finishing pigs against GnRF with Improvac®. The estimated performance economic differences between immunized (IM) non-IM from perspective producers packers, based two recent meta-analyses in male female pigs. It populated data 9 countries four continents (Europe, Asia, North Latin-America). One-way sensitivity analyses (OWSA) were define profitability....
Rotavirus (RV) infection causes acute rotavirus gastroenteritis (RVGE) in infants. Safe and effective RV vaccines are available, of which Mexico has included one its national immunization program (NIP) since 2007. Health outcome gains, expressed quality-adjusted life years (QALYs), cost improvements important additional factors for the selection a NIP vaccine. These two were analyzed here over year implementing three vaccines: 2-dose Rotarix (HRV), versus 3-dose RotaTeq (HBRV), Rotasiil...
Background. Malaria is a major public health burden in sub-Saharan Africa. This study estimated the cost-effectiveness and budget impact of adding four-dose malaria vaccination infants or children to existing interventions 41 endemic countries Methods. A static Markov cohort model followed simulated 2017 birth (36.5 million children) for 15 years 5-day cycles, comparing three strategies: child (doses at ages 6, 7.5, 9, 27 months); infant 10, 14 weeks 21 no vaccination. The base-case analysis...
Background. Preventative malaria interventions include long-lasting insecticidal nets (LLINs), indoor residual spraying (IRS), and seasonal chemoprevention (SMC). The RTS,S vaccine candidate is now also approved for pilot introduction. This analysis estimates the optimal approach when combining current with to reduce under-five mortality in Ghana at lowest cost. Methods. A vector model was combined a static human cohort model, using country-specific unit costs. Current coverage of each...
Influenza is an infectious disease causing a high annual economic and public health burden. The most efficient management of the through prevention with vaccination. Many influenza vaccines are available, varying efficacy cost, targeting different age groups. Therefore, strategic decision-making about which vaccine to deliver whom warranted improve efficiency. We present use constrained optimization (CO) model evaluate targeted strategies for providing in three adult groups USA. CO was...
Adding malaria vaccination to existing interventions could help reduce the health burden due malaria. This study modelled potential public impact of RTS,S candidate vaccine in 42 malaria-endemic countries sub-Saharan Africa. An individual-based Markov cohort model was constructed with three categories transmission intensity and six successive immunity levels. The cycle time 5 days. Vaccination assumed risk infection, no other effects. Vaccine efficacy wane exponentially over time. Malaria...
There are concerns in Europe regarding the service provision and accessibility of multidisciplinary cardiac rehabilitation (MDCR) general, particularly ambulatory settings. This paper analyses utilization outpatient MDCR its determinants after revascularization or valve surgery Belgium.Claims data for all patients discharged 2007 a percutaneous intervention were available from Belgian Common Sickness Funds Agency. Logistic regressions performed to identify demographic socioeconomic...
Background and Purpose Timely intravenous administration of recombinant tissue-type plasminogen activator (alteplase, rTPA) to patients with evolving ischemic stroke improves neurological outcome. The present study was designed compare the effects rTPA staphylokinase (Sak), a highly fibrin-specific thrombolytic agent, in an experimental model rabbit embolic stroke. Methods Groups 5 12 rabbits were given saline or heparin aspirin with, addition, either Sak (1 2 mg/kg infused over 30 minutes...
Many countries struggle with the prioritisation of introducing new vaccines because budget limitations and lack focus on public health goals. A model has been developed that defines how specific goals can be optimised through immunisation within vaccination constraints. Japan, as a country example, could introduce 4 pediatric targeting influenza, rotavirus, pneumococcal disease mumps known burden disease, vaccine efficacies maximum achievable coverages. Operating under constraints,...