A5006806488- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Pancreatic and Hepatic Oncology Research
- Pharmacological Effects and Toxicity Studies
- Pharmaceutical Practices and Patient Outcomes
- Gastric Cancer Management and Outcomes
- Antibiotic Use and Resistance
- Cancer therapeutics and mechanisms
- Cancer Genomics and Diagnostics
- Drug Transport and Resistance Mechanisms
- Epilepsy research and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Helminth infection and control
- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
- Patient Safety and Medication Errors
- Animal Nutrition and Physiology
- Meat and Animal Product Quality
- Lung Cancer Research Studies
- Malaria Research and Control
- Hepatocellular Carcinoma Treatment and Prognosis
- Economic and Financial Impacts of Cancer
- Childhood Cancer Survivors' Quality of Life
Clinica Universidad de Navarra
2014-2024
Zoetis (United States)
2018-2024
Universidad de Navarra
1998-2009
Clinical Research Management
2007
The University of Texas MD Anderson Cancer Center
2007
American Pharmacists Association
2000-2002
Mosquitoes that feed on animals can survive and mediate residual transmission of malaria even after most humans have been protected with insecticidal bednets or indoor sprays. Ivermectin is a widely-used drug for treating parasites also insecticidal, killing mosquitoes treated subjects. Mass administration ivermectin to livestock could be particularly useful tackling by zoophagic vectors evade human-centred approaches. comes from different chemical class active ingredients currently used...
Irinotecan (CPT-11) is a drug used against wide variety of tumors, which can cause severe toxicity, possibly leading to the delay or suspension cycle, with consequent impact on prognosis survival. The main goal this work predict toxicities derived from CPT-11 using artificial intelligence methods. data for study conformed 53 cycles FOLFIRINOX, corresponding patients metastatic colorectal cancer. Supported by several demographic data, blood markers and pharmacokinetic parameters resulting...
Ivermectin is a widely used antiparasitic drug with known efficacy against several single-strain RNA viruses. Recent data shows significant reduction of SARS-CoV-2 replication in vitro by ivermectin concentrations not achievable safe doses orally. Inhaled therapy has been success for other antiparasitics. An ethanol-based formulation was administered once to 14 rats using nebulizer capable delivering particles alveolar deposition. Rats were randomly assigned into three target dosing groups,...
Abstract Mass administration of endectocides, drugs that kill blood-feeding arthropods, has been proposed as a complementary strategy to reduce malaria transmission. Ivermectin is one the leading candidates given its excellent safety profile. Here we provide proof effect ivermectin can be boosted at two different levels by inhibiting cytochrome or ABC transporter in mammal host and target mosquitoes. Using mini-pig model, show drug-mediated P450/ABC inhibition results 3-fold increase time...
Precision medicine is an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, lifestyle each person. transforming clinical biomedical research, as well health care itself from a conceptual, methodological viewpoint, providing extraordinary opportunities to improve public lower the costs of healthcare system. However, implementation precision poses ethical-legal, regulatory, organizational, knowledge-related challenges....
OBJECTIVE: To report a case of delayed elimination high-dose methotrexate (MTX) associated with concomitant omeprazole administration. CASE SUMMARY: Delayed MTX was observed in an 11-year-old white boy who concomitantly received and omeprazole. The patient's serum creatinine liver function tests were normal during treatment follow-up. only medication we suspected inhibiting 20 mg every 12 hours. Twenty-four hours after the first cycle (15 g), discontinued. Thereafter, patient one without...
Acute intermittent porphyria (AIP) is a rare metabolic disorder caused by haploinsufficiency of hepatic porphobilinogen deaminase (PBGD), the third enzyme heme biosynthesis. Individuals with AIP experience neurovisceral attacks closely associated overproduction potentially neurotoxic precursors.
The aim of this study was to analyze the relationship between exposure high-dose methotrexate (HDMTX) and tumor response in terms survival children with osteosarcoma.This included 44 patients (479 courses) who received a median dose 5.92 g/m2 MTX (interquartile range (IQR) 2.37 g/m2) 4-hr infusion. mean area under concentration-time curve (AUC) estimated by parametric methods (non-parametric expectation maximization, NPEM), concentration at end infusion were considered be parameters. Tumor...
To evaluate the effect of concomitant antiepileptic therapy on levetiracetam (LEV) pharmacokinetics.A 6-year retrospective observational study. Patients were grouped according to drug used as medication: group A, LEV in monotherapy; B, + enzyme-inducing drugs (EIAEDs); and C, non-enzyme-inducing (NEIAEDs). Apparent oral clearance (LEV CL/F) basal serum concentrations C0) compared among different groups by analysis variance.A total 330 C0 corresponding 205 patients (56% men) identified. The...
La determinación de las concentraciones plasmáticas antiepilépticos para el tratamiento y profilaxis la epilepsia es una estrategias que permiten mejorar los resultados clínicos, reduciendo efectos adversos aumentando efectividad. El objetivo este artículo revisar aspectos básicos en mediante un documento consenso realizado avalado por grupo trabajo farmacocinética farmacogenética Sociedad Española Farmacia Hospitalaria (PK.gen). Monitoring plasma levels of antiepileptic drugs for the...
OBJECTIVE: To establish a relationship between the pharmacokinetics of high-dose methotrexate (MTX) and toxicity in children pediatric oncology department to reassess MTX concentrations at which patients would be high risk for toxic effects. METHODS: This study included 37 (227 treatment courses) who received median dose 4.87 g/m 2 4-hour infusion. The population pharmacokinetic parameters were estimated by parametric (IT2B) nonparametric methods (NPEM). Gastrointestinal, renal, hematologic...
Background: Levetiracetam (LEV) is a second-generation antiepileptic drug extensively used in therapeutics. The aim of this study was to evaluate the influence that sex, age, and weight exert on LEV pharmacokinetics clinical practice. Methods: We conducted 6-year retrospective observational study. Patients were classified subgroups according (normal range, overweight, obese), age (young adult: 16–30 years old, middle-aged 31–50 advanced 51–64 elderly ≥65 old). compared apparent oral...
Tegafur, a prodrug of 5-fluorouracil (5-FU), is an oral fluorouracil antitumor drug used for the management adenocarcinomas. It has efficacy similar to that intravenous 5-FU, with potential advantages in terms convenience and quality life patient cost-effectiveness as compared chemotherapy. The authors developed high-performance liquid chromatography (HPLC) assay determination tissue or plasma tegafur 5-FU concentration single step extraction HPLC injection. retention times were 5 16.5...
An existing model was used to identify key drivers of profitability and estimate the impact on environmental sustainability when immunizing finishing pigs against GnRF with Improvac®. The estimated performance economic differences between immunized (IM) non-IM from perspective producers packers, based two recent meta-analyses in male female pigs. It populated data 9 countries four continents (Europe, Asia, North Latin-America). One-way sensitivity analyses (OWSA) were define profitability....