A5087529988- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Patient Safety and Medication Errors
- Antibiotic Use and Resistance
- Pharmacovigilance and Adverse Drug Reactions
- Acute Lymphoblastic Leukemia research
- Pharmacy and Medical Practices
- Antibiotics Pharmacokinetics and Efficacy
- Drug-Induced Adverse Reactions
- Patient Satisfaction in Healthcare
- Antimicrobial Resistance in Staphylococcus
- Healthcare Decision-Making and Restraints
- Long-Term Effects of COVID-19
- Pneumonia and Respiratory Infections
- Bacterial Identification and Susceptibility Testing
- Childhood Cancer Survivors' Quality of Life
- Electroconvulsive Therapy Studies
- Pituitary Gland Disorders and Treatments
- Poisoning and overdose treatments
- COVID-19 and healthcare impacts
- Chronic Kidney Disease and Diabetes
- Emergency and Acute Care Studies
- Cancer Treatment and Pharmacology
- Bipolar Disorder and Treatment
- Allergic Rhinitis and Sensitization
Clinica Universidad de Navarra
2014-2025
Sociedad Española de Farmacología Clínica
2020-2021
Universidad de Navarra
2000-2019
Intravenous drug administration is associated with potential complications, such as phlebitis. The physiochemical characteristics of the infusate play a very important role in some these problems. aim this study was to standardize dilutions intravenous drugs most commonly used hospitalized adult patients and characterize their pH, osmolarity cytotoxic nature better guide selection appropriate vascular access. project conducted three phases: (i) standardization therapy, which using modified...
Adverse drug reaction (ADR) spontaneous reporting is the primary method of postmarketing surveillance; although it an important part surveillance, underused. Before 2004, almost no ADRs were reported in our 400-bed hospital. As electronic hospital information system was available hospital, we developed a tool (ADR-RS-IHIS) for ADR integrated into to facilitate through easy use, automatic input certain information, increased accessibility, real-time review, and intervention.To analyze...
OBJECTIVE: To report a case of delayed elimination high-dose methotrexate (MTX) associated with concomitant omeprazole administration. CASE SUMMARY: Delayed MTX was observed in an 11-year-old white boy who concomitantly received and omeprazole. The patient's serum creatinine liver function tests were normal during treatment follow-up. only medication we suspected inhibiting 20 mg every 12 hours. Twenty-four hours after the first cycle (15 g), discontinued. Thereafter, patient one without...
The aim of this study was to analyze the relationship between exposure high-dose methotrexate (HDMTX) and tumor response in terms survival children with osteosarcoma.This included 44 patients (479 courses) who received a median dose 5.92 g/m2 MTX (interquartile range (IQR) 2.37 g/m2) 4-hr infusion. mean area under concentration-time curve (AUC) estimated by parametric methods (non-parametric expectation maximization, NPEM), concentration at end infusion were considered be parameters. Tumor...
Hospitalized patients are complex and institutions have to face the high cost of critical care limited resources ward. Intermediate appears as an attractive strategy provide rational according patient needs. It is interesting scenario expand co-management teaching.Retrospective observational study.Intermediate unit (ImCU) a single academic hospital.456 admitted from April 2006 2010 were included in study. Demographics, admission physiologic parameters in-hospital mortality recorded. We used...
OBJECTIVE: To establish a relationship between the pharmacokinetics of high-dose methotrexate (MTX) and toxicity in children pediatric oncology department to reassess MTX concentrations at which patients would be high risk for toxic effects. METHODS: This study included 37 (227 treatment courses) who received median dose 4.87 g/m 2 4-hour infusion. The population pharmacokinetic parameters were estimated by parametric (IT2B) nonparametric methods (NPEM). Gastrointestinal, renal, hematologic...
<h3>Objective</h3> Electronic alert systems have shown their capacity for improving the detection of acute kidney injury (AKI). The aim this study was to design and implement a clinical decision support system (CDSS) drug selection reducing nephrotoxic use in patients with AKI. <h3>Methods</h3> designed as an intervention comparing pre post cohort admitted during April 2014 2015, respectively (phase I phase II). CDSS which provided function information. Furthermore, interruptive detect...
Cuantificar el impacto de la integración un residente Farmacia Hospitalaria en equipo asistencial. Describir sistemática trabajo seguida. El se integró durante 8 meses oncología médica, unidad cuidados intensivos y hospital día oncología. Las intervenciones registraron evaluaron mediante programa informático Atefarm®. Se las características, tipo gravedad los problemas aceptación coste evitado intervenciones. detectaron 2.415 relacionados con medicamentos (10 por 3,6 paciente) realizaron...
We describe a Caucasian man in his late 60s who was admitted to the intensive care unit (ICU) with history of cardiogenic shock secondary an acute myocardial infarction. The patient's baseline serum creatinine levels were 0.9–1 mg/dL. On day 7 admission treatment quetiapine initiated due delirium episode. next patient developed erythematous-maculopapular rash and fever, eosinophilia blood count. Over following days experienced deterioration kidney function requiring continuous renal...
Background: The proper dosage of antibiotics is a key element in the effective treatment infection, especially critically ill patients. This study aimed to evaluate efficacy optimized meropenem regimens based on pharmacokinetic/pharmacodynamic criteria patients admitted intensive care unit. Methods: observational, naturalistic, retrospective, unicentric cohort was performed between May 2011 and December 2017. clinical bacteriologic responses 77 control unit receiving were compared with those...
A case of severe bilateral sensorineural hearing loss associated with oral morphine is reported.A 52-year-old Spanish man was admitted to the intensive care unit a Glasgow Coma Scale score 3, fever, and sudden tinnitus in both ears. His medical history included type 2 diabetes mellitus, depression, sleep disorder, hypertension. The patient also had pyelonephritis 2011 pulmonary embolism 2014, requiring placement an inferior vena cava filter chronic anticoagulation. appeared after initiation...
Antimicrobial stewardship programs (ASP) promote appropriate antimicrobial use. We present a 4-year retrospective study that evaluated the clinical impact of acceptance recommendations made by meropenem-focused ASP. A total 318 meropenem audits were performed. The ASP team (comprising infectious disease physicians, pharmacists and microbiologists) considered use in 96 (30.2%) to be inappropriate. reasons consider these uses inappropriate possibility de-escalating narrower-spectrum...
OBJECTIVE:To report a case of delayed elimination high-dose methotrexate (MTX) associated with concomitant omeprazole administration.CASE SUMMARY:Delayed MTX was observed in an 11-year-old white boy who concomitantly received and omeprazole. The patient's serum creatinine liver function tests were normal during treatment follow-up. only medication we suspected inhibiting 20 mg every 12 hours. Twenty-four hours after the first cycle (15 g), discontinued. Thereafter, patient one without month...