A5017188899- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Functional Brain Connectivity Studies
- Cardiac Imaging and Diagnostics
- Advanced Neuroimaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Renal and Vascular Pathologies
- Lanthanide and Transition Metal Complexes
- Parkinson's Disease Mechanisms and Treatments
- Advanced NMR Techniques and Applications
- Neural dynamics and brain function
- Motor Control and Adaptation
- Cerebrovascular and Carotid Artery Diseases
- Vestibular and auditory disorders
- Glioma Diagnosis and Treatment
- Dementia and Cognitive Impairment Research
- RNA regulation and disease
- Electron Spin Resonance Studies
- Fetal and Pediatric Neurological Disorders
- Neuroscience and Music Perception
- Analytical Chemistry and Sensors
- EEG and Brain-Computer Interfaces
- Bone health and osteoporosis research
- Neural and Behavioral Psychology Studies
- Attention Deficit Hyperactivity Disorder
Clinica Universidad de Navarra
2017-2025
Navarre Institute of Health Research
2019-2025
University of Pennsylvania
2001-2024
Universidad de Navarra
2010-2023
Centro de Investigación Biomédica en Red
2015
Biomedical Research Networking Center on Neurodegenerative Diseases
2015
Instituto de Salud Carlos III
2015
University College London
2006
Wellcome Trust
2006
Abstract Arterial spin labeling (ASL) is capable of noninvasively measuring blood flow by magnetically tagging the protons in arterial blood, which has been conventionally achieved using instantaneous (PASL) or continuous (CASL) RF pulses. As an intermediate method, pseudocontinuous ASL (pCASL) utilizes a train discrete pulses to mimic that often unavailable on imagers due requirement transmit capabilities. In present study, we implemented two versions pCASL ( balanced and unbalanced...
Abstract Accurate assessment of cerebral perfusion is vital for understanding the hemodynamic processes involved in various neurological disorders and guiding clinical decision‐making. This guidelines article provides a comprehensive overview quantitative imaging brain using multi‐timepoint arterial spin labeling (ASL), along with recommendations its acquisition quantification. A major benefit acquiring ASL data multiple label durations and/or post‐labeling delays (PLDs) being able to...
ABSTRACT Background We aimed to analyze the diagnostic accuracy of an automated segmentation and quantification method SNc locus coeruleus (LC) volumes based on neuromelanin (NM)‐sensitive MRI (NM‐MRI) in patients with idiopathic (iPD) monogenic Parkinson's disease (PD). Methods Thirty‐six (23 13 PARKIN or LRRK2 mutations) 37 age‐matched healthy controls underwent 3T‐NM‐MRI. LC volumetry were performed using fully multi‐image atlas segmentation. The performance differentiate PD from was...
Abstract Objectives This study aimed at developing technical recommendations for the acquisition, processing and analysis of renal ASL data in human kidney 1.5 T 3 field strengths that can promote standardization perfusion measurements facilitate comparability results across scanners multi-centre clinical studies. Methods An international panel 23 experts followed a modified Delphi process, including on-line surveys two in-person meetings, to formulate series consensus statements regarding...
Abstract Monitoring of oxygen saturation in jugular venous blood gives an estimate the balance global delivery and cerebral consumption. We present a noninvasive approach to measure vivo internal vein using MR susceptometry by exploiting characteristic susceptibility deoxyhemoglobin, demonstrate feasibility performing such measurements group subjects. assessed sensitivity method for detecting small changes monitoring variations observed during breath‐holding hypoventilation experiments....
Pharmacological magnetic resonance imaging (phMRI) is increasingly being used in drug discovery and development to speed the translation from laboratory clinic. The two primary methods phMRI include blood-oxygen-level-dependent (BOLD) contrast arterial spin-labeled (ASL) perfusion MRI. BOLD has been widely applied existing studies. However, because of lack absolute quantification poor reproducibility over time scales longer than hours or across scanning sessions, fMRI may not be suitable...
Modular structure is ubiquitous among real-world networks from related proteins to social groups. Here we analyze the modular organization of brain at a large scale (voxel level) extracted functional magnetic resonance imaging signals. By using random-walk-based method, unveil modularity webs and show modules with spatial distribution that matches anatomical structures significance. The role each node in network studied by analyzing its patterns inter- intramodular connections. Results...
Purpose To investigate whether arterial spin labeling (ASL) MRI could detect renal hemodynamic impairment in diabetes mellitus (DM) along different stages of chronic kidney disease (CKD). Materials and Methods Three Tesla (3T) ASL‐MRI was performed to evaluate blood flow (RBF) 91 subjects (46 healthy volunteers 45 type 2 diabetic patients). Patients were classified according their estimated glomerular filtration rate (eGFR) as group I (eGFR > 60 mL/min/1.73 m ), II (60 ≥ eGFR>30 or III...
Abstract Purpose The potential of renal MRI biomarkers has been increasingly recognised, but clinical translation requires more standardisation. PARENCHIMA consensus project aims to develop and apply a process for generating technical recommendations on MRI. Methods A task force was formed in July 2018 focused five methods. draft attaining distributed publicly consultation finalised at an open meeting (Prague, October 2018). Four expert panels completed surveys between March 2019, discussed...
The luminescence lifetime distribution can be used to determine the of quencher concentrations in a heterogeneous sample. We describe frequency domain instrument for real-time measurements phosphorescence distributions microheterogeneous objects. In this system (1) an array harmonics (typically 100–200 frequencies) is modulate excitation source, light emitting diode. Due relatively long triplet state lifetimes, frequencies required modulation are typically below 40 000 kHz, which allows...
Single shot 3D GRASE is less sensitive to field inhomogeneity and susceptibility effects than gradient echo based fast imaging sequences while preserving the acquisition speed. In this study, a continuous arterial spin labeling (CASL) pulse was added prior single readout quantitative perfusion measurements were carried out at 3 T, rest during functional activation. The sequence performance evaluated by comparison with CASL EPI readout. It shown that using can be performed safely on humans T...
Abstract NMR was used to measure matrix water content in normal and hypomineralized cortical bone. Water showed an inverse relationship with mineral content, suggesting it could serve as a surrogate for the bone's degree of mineralization. Introduction: So far, true bone density (DMB; mineralization bone) can not be measured nondestructively. Materials Methods: Here, new technique combining1H nuclear magnetic resonance (NMR) spectroscopy deuterium isotope exchange from two groups rabbits:...
Quantification of water permeability can improve the accuracy perfusion measurements obtained with arterial spin labeling (ASL) methods, and may provide clinically relevant information regarding functional status microvasculature. The amount labeled in vascular tissue compartments an ASL experiment be estimated based on their distinct diffusion characteristics, turn, determined from relative contributions. In present study, a hybrid magnetic resonance imaging technique was introduced by...
An improved arterial spin labeling (ASL) perfusion technique that combines pseudo-continuous and a T2*-insensitive sequence (GRASE) with background suppression was used to acquire maps in normal volunteers stroke patients. It is shown measurements obtained less than 1 min of scan time are reproducible, coefficient variation 7%. The generated from these data can be characterize the lesion.