A5103237393- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Imaging and Diagnostics
- Neural dynamics and brain function
- Neurological Disease Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
- EEG and Brain-Computer Interfaces
- Dementia and Cognitive Impairment Research
- Thermoregulation and physiological responses
- Cardiovascular Disease and Adiposity
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Anesthesia and Neurotoxicity Research
- Cardiovascular Health and Disease Prevention
- Fetal and Pediatric Neurological Disorders
- Neurological Disorders and Treatments
- Epilepsy research and treatment
- Body Composition Measurement Techniques
- Intensive Care Unit Cognitive Disorders
- Retinal Imaging and Analysis
- Electron Spin Resonance Studies
- Anesthesia and Sedative Agents
Hangzhou First People's Hospital
2025
Westlake University
2025
Binghamton University
2016-2025
Beijing Normal University
2024
University of Virginia
2024
Zhejiang University
2024
Beth Israel Deaconess Medical Center
2008-2017
Harvard University
2008-2017
Brown University
2017
Brigham and Women's Hospital
2017
Abstract Continuous labeling by flow‐driven adiabatic inversion is advantageous for arterial spin (ASL) perfusion studies, but details of the implementation, including inefficiency, magnetization transfer, and limited support continuous‐mode operation on clinical scanners, have restricted benefits this approach. Here a new approach to continuous that employs rapidly repeated gradient radio frequency (RF) pulses achieve with high efficiency characterized. The theoretical underpinnings,...
To examine regional cerebral blood flow (rCBF) in incident mild cognitive impairment (MCI) and Alzheimer disease (AD) by using continuous arterial spin-labeling (CASL) magnetic resonance (MR) imaging.This study was approved the local institutional review board compliant with HIPAA regulations. Informed consent obtained. rCBF measured 38 control subjects, 29 MCI patients, 37 AD patients who were participating a longitudinal epidemiologic study. Multisection CASL MR imaging alternating single...
Abstract Accurate assessment of cerebral perfusion is vital for understanding the hemodynamic processes involved in various neurological disorders and guiding clinical decision‐making. This guidelines article provides a comprehensive overview quantitative imaging brain using multi‐timepoint arterial spin labeling (ASL), along with recommendations its acquisition quantification. A major benefit acquiring ASL data multiple label durations and/or post‐labeling delays (PLDs) being able to...
Abstract Arterial spin labeling perfusion MRI can suffer from artifacts and quantification errors when the time delay between arrival of labeled blood in tissue is uncertain. This transit particularly uncertain broad clinical populations, where reduced or collateral flow may occur. Measurement by acquisition arterial signal at many different delays typically extends imaging degrades sensitivity resulting images. Acquisition maps same spatial resolution as images not be necessary, however,...
Background and Purpose— The purpose of this study was to examine regional cerebral blood flow (rCBF) in normal cognitive-performing subjects with hypertension (HTN) using continuous arterial spin-labeled MRI. most common explanation for the effect pressure on cognition is that HTN increases risk cerebrovascular disease, it may increase Alzheimer disease possibly through small vessel ischemia, oxidative stress, inflammation. However, few studies date have examined rCBF cognitively...
Despite the significant impact of postoperative delirium on surgical outcomes and long-term prognosis older patients, its neural basis has not yet been clarified. In this study we investigated premorbid brain microstructural integrity, as measured by diffusion tensor imaging before surgery, incidence severity, well relationship among presurgical cognitive performance, abnormalities delirium. Presurgical scans 136 (≥70 years), dementia-free subjects from prospective Successful Aging after...
Abstract Arterial spin labeling (ASL) perfusion measurements may have many applications outside the brain. In abdomen, severe image artifacts can arise from motions between acquisitions of multiple signal averages in ASL, even with single‐shot acquisition. Background suppression and respiratory motion synchronization techniques be used to ameliorate these artifacts. Two separate vivo studies renal imaging using pulsed continuous ASL (pCASL) were performed. The first study assessed various...
Creating images of the transit delay from labeling location to image tissue can aid optimization and quantification arterial spin perfusion measurements may provide diagnostic information independent perfusion. Unfortunately, measuring requires acquiring a series with different timing that adds time cost increases noise study. Here, we implement evaluate proposed Hadamard encoding speeds imaging improves signal‐to‐noise ratio efficiency. Volumetric in human volunteers confirmed theoretical...
Purpose To investigate whether measurement of arterial transit time (ATT) can improve the accuracy spin labeling (ASL) cerebral blood flow (CBF) quantification in an elderly cohort due to potentially prolonged ATT cohort. Materials and Methods We employed a 1-minute, low-resolution (12 mm in-plane), sequential multidelay (both with without vessel suppression) approach characterize correct errors CBF imaging elderly, clinical In all, 140 nondemented subjects greater than 70 years old were...
Purpose:To demonstrate an arterial spin-labeling (ASL) magnetic resonance (MR) angiographic technique that covers the entire cerebral vasculature and yields transparent-background, time-resolved hemodynamic, vessel-specifi c information similar to obtained with x-ray digital subtraction angiography (DSA) without use of exogenous contrast agents. Materials Methods:Prior institutional review board approval written informed consent were for this HIPAA-compliant study in which 12 healthy...
Abstract Changes in brain resting-state functional connectivity (rsFC) were investigated using a longitudinal design by following 2-month focused attention meditation (FAM) practice and analyzing their association with FAM time. Ten novice meditators recruited from university course. Participants scanned fMRI sequence multi-echo EPI acquisition at baseline the follow-up. Total time was calculated daily log of participants. We observed significantly increased rsFC between posterior cingulate...
Background: This is the first longitudinal study to assess regional cerebral blood flow (rCBF) changes during progression from normal control (NC) through mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Objective: We aim determine if perfusion MRI biomarkers, derived our prior cross-sectional study, can predict onset decline of AD. Methods: Perfusion MRIs using arterial spin labeling (ASL) were acquired in 15 stable-NC, 14 NC-to-MCI, 16 stable-MCI, 18 MCI/AD-to-AD participants...
Cortical folding is one of the most complex processes that occur during normal development human brain. Despite variability in patterns different individuals, there are a few specific types preserved within individuals or across species. The origin and formation mechanism variable regular brain yet remains to be thoroughly explored. This study aims delineate how interplay between differential tangential growth cerebral cortex axonal fiber tension induces regulates developing To achieve this...
ECMO treatment for critically ill patients mostly requires family members to make surrogate decisions. However, the process and experience of members' participation in decision making have not been well described. To explore who were asked consent gain insight into factors that promote hinder their decision-making. A descriptive qualitative study. Data collected using a semi-structured interview method analysed traditional content analysis approaches. The cohort included nineteen ICU from...
Abstract Understanding the development of complex brain surface morphologies during fetal stage is essential for uncovering mechanisms behind disorders linked to abnormal cortical folding. However, knowledge spatiotemporal evolution landmarks limited due lack longitudinal data capturing multiple timepoints individual brains. In this study, we develop and validate a true-scale, image-based mechanical model explore sulcal pits in Our model, constructed using magnetic resonance imaging (MRI)...
ABSTRACT INTRODUCTION Arterial spin labeling (ASL) is a safe, noninvasive imaging method for evaluating cerebral blood flow (rCBF). The purpose of this article to present ASL features 38 elderly cognitively normals (CN) with their rCBF values and an averaged profile targeted anatomic regions values. METHODS: Thirty‐eight CN underwent MR especially voxel morphometric techniques fusing the anatomical images standard reference brain (colin27). were fused echo planar images, which then...
Blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) has been widely used to investigate spontaneous low-frequency signal fluctuations across brain resting state networks. However, BOLD only provides relative measures of fluctuations. Arterial Spin Labeling (ASL) MRI holds great potential for quantitative measurements network This study systematically quantified the large-scale networks using ASL data from 20 healthy volunteers by separating them global and caused...
Background: Reliable cerebral blood flow (CBF) biomarkers using a noninvasive imaging technique are sought to facilitate early diagnosis and intervention in Alzheimer’s disease (AD). Objective: We aim identify brain regions which CBF values affected related cognitive decline AD large cohort. Methods: Perfusion MRIs continuous arterial spin labeling were acquired at 1.5 T 58 normal controls (NC), 50 mild impairments (MCI), 40 subjects from the Cardiovascular Health Study Cognition Study....
Abstract Background The choroid plexus is a major contributor to the generation of cerebrospinal fluid (CSF) and maintenance its electrolyte metabolite balance. Here, we sought characterize blood flow dynamics using arterial spin labeling (ASL) MRI establish ASL as non-invasive tool for function disease studies. Methods Seven healthy volunteers were imaged on 3T MR scanner. images acquired with 12 durations post delays. Regions manually segmented high-resolution T 1 weighted images. Choroid...