A5000867378- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Dementia and Cognitive Impairment Research
- Cardiac, Anesthesia and Surgical Outcomes
- Frailty in Older Adults
- Family and Patient Care in Intensive Care Units
- Geriatric Care and Nursing Homes
- Advanced MRI Techniques and Applications
- Long-Term Effects of COVID-19
- Diet and metabolism studies
- Functional Brain Connectivity Studies
- Health Systems, Economic Evaluations, Quality of Life
- Traumatic Brain Injury and Neurovascular Disturbances
- Glycosylation and Glycoproteins Research
- Alcoholism and Thiamine Deficiency
- Neurological Disease Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Health and Well-being Studies
- COVID-19 Clinical Research Studies
- Thermal Regulation in Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
Hebrew SeniorLife
2016-2025
Beth Israel Deaconess Medical Center
2016-2025
Harvard University
2016-2025
Berenson Allen Center for Noninvasive Brain Stimulation
2023
Biogen (United States)
2021
Hadassah Medical Center
2012-2020
Institute on Aging
2020
Brigham and Women's Hospital
2008-2019
Massachusetts General Hospital
2009-2019
Marcus (United States)
2019
Delirium is common after cardiac surgery and may be associated with long-term changes in cognitive function. We examined postoperative delirium the trajectory during first year surgery.We enrolled 225 patients 60 years of age or older who were planning to undergo coronary-artery bypass grafting valve replacement. Patients assessed preoperatively, daily hospitalization beginning on day 2, at 1, 6, 12 months surgery. Cognitive function was use Mini-Mental State Examination (MMSE; score range,...
To examine the impact of delirium on trajectory cognitive function in a cohort patients with Alzheimer disease (AD).A secondary analysis data collected from large prospective cohort, Massachusetts Alzheimer's Disease Research Center's patient registry, examined performance over time who developed (n = 72) or did not develop 336) during course their illnesses. Cognitive was measured by change score Information-Memory-Concentration (IMC) subtest Blessed Dementia Rating Scale. Delirium...
OBJECTIVES: To determine whether patients who developed delirium after cardiac surgery were at risk of functional decline. DESIGN: Prospective cohort study. SETTING: Two academic hospitals and a Veterans Affairs Medical Center. PARTICIPANTS: One hundred ninety aged 60 older undergoing elective or urgent surgery. MEASUREMENTS: Delirium was assessed daily diagnosed according to the Confusion Assessment Method. Before 1 12 months postoperatively, for function using instrumental activities...
<h3>Importance</h3> Delirium is common among older emergency department (ED) patients, associated with high morbidity and mortality, frequently goes unrecognized. Anecdotal evidence has described atypical presentations of coronavirus disease 2019 (COVID-19) in adults; however, the frequency outcomes delirium ED patients COVID-19 infection have not been well described. <h3>Objective</h3> To determine how adults present to their hospital outcomes. <h3>Design, Setting, Participants</h3> This...
<h3>Background</h3>Delirium is characterized by acute cognitive impairment. We examined the association of delirium with long-term trajectories in older adults Alzheimer disease (AD).<h3>Methods</h3>We evaluated prospectively collected data from a nested cohort hospitalized patients AD (n = 263) Massachusetts Disease Research Center patient registry between January 1, 1991, and June 30, 2006 (median follow-up duration, 3.2 years). Cognitive function was measured using...
Importance Delirium is a common, serious, and potentially preventable problem for older adults, associated with adverse outcomes. Coupled its nature, these sequelae make delirium significant public health concern; understanding economic costs important policy makers care leaders to prioritize care. Objective To evaluate current 1-year attributable postoperative in patients undergoing elective surgery. Design, Setting, Participants This prospective cohort study included 497 from the...
Importance The study results suggest that delirium is the most common postoperative complication in older adults and associated with poor outcomes, including long-term cognitive decline incident dementia. Objective To examine patterns pace of up to 72 months (6 years) a cohort following delirium. Design, Setting, Participants This was prospective, observational follow-up 560 community-dwelling (older than 70 ongoing Successful Aging after Elective Surgery began 2010. data were analyzed from...
Background: Hospitalization, frequently complicated by delirium, can be a life-changing event for patients with Alzheimer disease (AD). Objective: To determine risks institutionalization, cognitive decline, or death associated hospitalization and delirium in AD. Design: Prospective cohort enrolled between 1991 2006 into the Massachusetts Alzheimer's Disease Research Center (MADRC) patient registry. Setting: Community-based. Participants: 771 persons aged 65 years older clinical diagnosis of...
Brief cognitive screening measures are valuable tools for both research and clinical applications. The most widely used instrument, the Mini-Mental State Examination (MMSE), is limited in that it must be administered face-to-face, cannot participants with visual or motor impairments, protected by copyright. Screening instruments such as Telephone Interview Cognitive Status (TICS) were developed to provide a valid alternative, comparable cut-point scores rate global function.The MMSE,...
OBJECTIVES: To examine the rates of and risk factors for acute hospitalization in a prospective cohort older community‐dwelling patients with Alzheimer's disease (AD). DESIGN: Longitudinal patient registry. SETTING: AD research center. PARTICIPANTS: Eight hundred twenty‐seven persons AD. MEASUREMENTS: Acute after center visit was determined from Medicare database. Risk factor variables included demographics, dementia‐related, comorbidity diagnoses were measured interviews according to data....
Objectives To examine associations between the inflammatory marker C‐reactive protein ( CRP ) measured preoperatively and on postoperative day 2 POD 2) delirium incidence, duration, feature severity. Design Prospective cohort study. Setting Two academic medical centers. Participants Adults aged 70 older undergoing major noncardiac surgery (N = 560). Measurements Plasma was using enzyme‐linked immunosorbent assay. Delirium assessed from Confusion Assessment Method CAM interviews chart review....
Despite the significant impact of postoperative delirium on surgical outcomes and long-term prognosis older patients, its neural basis has not yet been clarified. In this study we investigated premorbid brain microstructural integrity, as measured by diffusion tensor imaging before surgery, incidence severity, well relationship among presurgical cognitive performance, abnormalities delirium. Presurgical scans 136 (≥70 years), dementia-free subjects from prospective Successful Aging after...
To establish Montreal Cognitive Assessment (MoCA) scores that correspond to well-established cut-points on the Mini-Mental State Examination (MMSE). Cross-sectional observational study. General medical service of a large teaching hospital. Individuals aged 75 and older (N = 199; mean age 84, 63% female). The MoCA (range 0-30) MMSE were administered within 2 hours each other. Abbreviated (A-MoCA; range 0-22) was calculated from full MoCA. Scores three tests analyzed using equipercentile...
Objective To examine the association of plasma neuroaxonal injury markers neurofilament light (NfL), total tau, glial fibrillary acid protein, and ubiquitin carboxyl‐terminal hydrolase L1 with delirium, delirium severity, cognitive performance. Methods Delirium case–no control (n = 108) pairs were matched by age, sex, surgery type, cognition, vascular comorbidities. Biomarkers measured in collected preoperatively (PREOP), 2 days (POD2) 30 postoperatively (PO1MO) using Simoa technology...
Background. Prior studies describe variable cerebral blood flow changes in delirium. This study aims to investigate older hospitalized patients with delirium, the population which most cases of delirium occur.
Objectives To describe baseline characteristics and quality assurance procedures of the Successful Aging after Elective Surgery ( SAGES ) study, which was designed to examine novel risk factors long‐term outcomes associated with delirium. Design Long‐term prospective cohort study. Setting Three academic medical centers. Participants Individuals aged 70 older (average age 77, 58% female) without recognized dementia scheduled for elective major surgery (N = 566). Measurements were assessed...