A5031206470- Health disparities and outcomes
- Balance, Gait, and Falls Prevention
- Cerebral Palsy and Movement Disorders
- Nutrition and Health in Aging
- Frailty in Older Adults
- Intensive Care Unit Cognitive Disorders
- HIV/AIDS Research and Interventions
- Geriatric Care and Nursing Homes
- Dementia and Cognitive Impairment Research
- Stroke Rehabilitation and Recovery
- HIV-related health complications and treatments
- Bone health and osteoporosis research
- Chronic Disease Management Strategies
- Aging, Elder Care, and Social Issues
- Health and Well-being Studies
- Nutritional Studies and Diet
- HIV/AIDS Impact and Responses
- Cardiac, Anesthesia and Surgical Outcomes
- Physical Activity and Health
- Diet and metabolism studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Urban Transport and Accessibility
- Health Systems, Economic Evaluations, Quality of Life
- Homelessness and Social Issues
- Poverty, Education, and Child Welfare
VA Boston Healthcare System
2014-2025
University of Massachusetts Boston
2013-2025
Massachusetts General Hospital
2022-2025
Providence VA Medical Center
2021-2022
Simon Fraser University
2021
Boston University
2021
Boston VA Research Institute
2020-2021
Geriatric Research Education and Clinical Center
2017-2020
Spaulding Rehabilitation Hospital
2018-2019
United States Department of Veterans Affairs
2019
Delirium is common after cardiac surgery and may be associated with long-term changes in cognitive function. We examined postoperative delirium the trajectory during first year surgery.We enrolled 225 patients 60 years of age or older who were planning to undergo coronary-artery bypass grafting valve replacement. Patients assessed preoperatively, daily hospitalization beginning on day 2, at 1, 6, 12 months surgery. Cognitive function was use Mini-Mental State Examination (MMSE; score range,...
OBJECTIVES: To investigate the relationships between uncontrolled and controlled hypertension, orthostatic hypotension (OH), falls in participants of Maintenance Balance, Independent Living, Intellect, Zest Elderly Boston Study (N=722, mean age 78.1). DESIGN: Prospective population-based study. SETTING: Community. PARTICIPANTS: Seven hundred twenty-two adults aged 70 older living within a 5-mile radius study headquarters at Hebrew Rehabilitation Center Boston. MEASUREMENTS: Blood pressure...
OBJECTIVES: To examine the relationship between gait speed and falls risk. DESIGN: Longitudinal analysis of association subsequent decline as a predictor future falls. SETTING: Population-based cohort study. PARTICIPANTS: Seven hundred sixty-three community-dwelling older adults underwent baseline assessments were followed for falls; 600 completed an 18-month follow-up assessment to determine change in MEASUREMENTS: Gait was measured during 4-m walk, data collected from monthly post-card...
OBJECTIVES: To identify risk factors for indoor and outdoor falls. DESIGN: Prospective cohort study. SETTING: The MOBILIZE Boston Study, a study of falls etiology in community‐dwelling older individuals. PARTICIPANTS: Seven hundred sixty‐five women men, mainly aged 70 older, from randomly sampled households the Boston, Massachusetts, area. MEASUREMENTS: Baseline data were collected by questionnaire comprehensive clinic examination. During follow‐up, participants recorded on daily calendars....
<h3>Background</h3>Delirium is characterized by acute cognitive impairment. We examined the association of delirium with long-term trajectories in older adults Alzheimer disease (AD).<h3>Methods</h3>We evaluated prospectively collected data from a nested cohort hospitalized patients AD (n = 263) Massachusetts Disease Research Center patient registry between January 1, 1991, and June 30, 2006 (median follow-up duration, 3.2 years). Cognitive function was measured using...
Our objective was to investigate the association between hypertension and concurrent impairments in mobility, cognition, mood; role of brain white matter hyperintensities mediating this association; impact these on disability mortality elderly hypertensive individuals.-Blood pressure, gait speed, digit symbol substitution test, Center for Epidemiological Studies Depression Scale were measured yearly (1992-1999) 4700 participants Cardiovascular Health Study (age: 74.7, 58% women, 17% blacks,...
Abstract Background Frailty is a key determinant of clinical outcomes. We sought to describe frailty among U.S. Veterans and its association with mortality. Methods Nationwide retrospective cohort study regular Affairs (VA) users, aged at least 65 years in 2002–2012, followed through 2014, using national VA administrative Medicare Medicaid data. A index (FI) for (VA-FI) was calculated the cumulative deficit method. Thirty-one age-related deficits health from diagnostic procedure codes were...
Background.The mechanisms linking falls and depression are still unknown. The aim of the study is to examine association between antidepressants, with indoor outdoor falls, investigate how antidepressants mediate this relationship.
Saczynski, Jane S.; Marcantonio, Edward R.; Quach, Lien; Fong, Tamara G.; Gross, Alden; Inouye, Sharon K.; Jones, Richard N. Author Information
Physical Activity (PA) and its links to frailty, quality of life (QoL), other comorbidities in older Ugandans living with HIV remain under-explored. We analyzed data from three annual assessments people (PLWH) age- sex-similar not (PnLWH). fitted linear generalized estimating equations (GEE) regression models estimate the correlates PA, including demographics, QoL, HIV, comorbidities. enrolled 297 PLWH 302 PnLWH. Older age (b = -157.34, 95% CI [-222.84, -91.83]), -979.88 [95% CI: -1878.48,...
<sec> <title>BACKGROUND</title> The HIV epidemic is a national focus within the United States (U.S.), Ending Epidemic (EHE) Initiative aiming to reduce new infections by 90% 2023 through scaling of prevention and treatment strategies. Data are crucial understanding HIV-related needs, barriers care, effectiveness interventions. While several publicly available datasets exist, few integrate multiple topic domains such as outcomes, social determinants health (SDOH), community-level factors....
Poor medication adherence is associated with negative health outcomes. We investigated whether poor increases the rate of falls as part Maintenance Balance, Independent Living, Intellect, and Zest in Elderly Boston (MOBILIZE Boston), a prospective, community-based cohort recruited for purpose studying novel risk factors falls.A total 246 men 408 women (mean age, 78 years) were followed occurrence (median follow-up, 1.8 years). Adherence was assessed by Morisky scale based on following four...
Objectives to estimate the association of social disconnectedness and perceived isolation with risk falls also investigate whether depression mediated this association.Method Biennial longitudinal survey data from 2006 2012 waves U.S. Health Retirement Study adults aged 65 older (N = 22,153 observations) were examined. The outcome variable was number self-reported over observation period. Independent variables included (social disconnectedness, isolation) depressive symptoms. Generalized...
Individuals with mild cognitive impairment (MCI), often a precursor to dementia, experience limitations in completing daily activities. These are particularly important understand, as they predict risk for dementia. Relations between functional changes and both decline upper extremity motor impairments have been reported, but the contribution of function relations independence remains poorly understood. We examined relationship cognition activities, whether this relation was mediated by...
In recent years, medical image analysis has played a vital role in detecting diseases their early stages. Medical images are rapidly becoming available for various applications to solve human problems. Therefore, complex features needed develop diagnostic system physicians provide better treatment. Traditional methods of abnormality detection suffer from misidentification abnormal regions the given data. Visual-saliency used locate abnormalities improve accuracy proposed work. This study...
Abstract Introduction Housing insecure veterans are aging, but the prevalence of Alzheimer's disease and related dementias (AD/ADRD) in population is unknown. Methods We calculated AD/ADRD diagnoses 2018 among that experienced homelessness, were at‐risk for or stably housed. determined acute care (emergency department, hospitalizations, psychiatric hospitalizations), any long‐term (nursing home, community‐based) use by housing status with an diagnosis. Results The overall homeless, at‐risk,...
Abstract Introduction With improved HIV treatment availability in sub‐Saharan Africa, the population of older people with (PWH) is growing. In this qualitative study, we intended to understand (1) lived experiences ageing rural Uganda, and without HIV, (2) their fears health priorities as they grow older. Methods We conducted 36 semi‐structured interviews individuals Mbarara, Uganda from October 2019 February 2020. Interview guide topics included age, physical functioning daily activities,...
COVID-19-related lockdowns and other public health measures may have differentially affected the quality of life (QOL) older people with without human immunodeficiency virus (HIV) in rural Uganda.The Quality Life Aging HIV Rural Uganda study enrolled aged over 49 from October 2020 to 2021. We collected data on stressors (behavior changes, concerns, interruptions care, income, food) participants' QOL. used linear regression estimate associations between QOL, adjusting for demographic...
The main aim of this study was to examine the differences between triple therapy (T: SSZ and HCQ added MTX) etanercept (E) MTX with regard infectious gastrointestinal (GI) adverse events (AEs) reported in Rheumatoid Arthritis Comparison Active Therapies Trial.The patients were 353 RA incomplete responders who randomized T (n = 178) or E 175). Of these, 88 switched alternative treatment from initial (E T) at 24 weeks per protocol. Infectious GI serious AEs (SAEs) non-serious (NAEs) during 48...
Abstract Background Electronic frailty indices (eFIs) are increasingly used to identify patients at risk for morbidity and mortality. Whether eFIs capture the spectrum of change, including decline, stability, improvement, is unknown. Methods In a nationwide retrospective birth cohort U.S. Veterans, validated eFI, 31 health deficits, was calculated annually using medical record insurance claims data (2002–2012). K-means clustering assign into trajectories measured 5 years prior death. Results...