A5061513042- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Adolescent Sexual and Reproductive Health
- HIV Research and Treatment
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- HIV/AIDS Impact and Responses
- Sex work and related issues
- Global Maternal and Child Health
- Poverty, Education, and Child Welfare
- Vaccine Coverage and Hesitancy
- COVID-19 epidemiological studies
- Aging, Elder Care, and Social Issues
- Medication Adherence and Compliance
- Sleep and related disorders
- Malaria Research and Control
- Syphilis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Prenatal Substance Exposure Effects
- Healthcare Systems and Reforms
- Drug-Induced Hepatotoxicity and Protection
- Global Health Workforce Issues
- Health disparities and outcomes
- Nutrition and Health in Aging
- Global Health and Surgery
Joint Clinical Research Centre
2014-2025
Center for Global Health
2019-2025
Massachusetts General Hospital
2019-2025
Mbarara University of Science and Technology
2014-2025
Makerere University
2004-2024
Integrated Community Based Initiatives
2017-2024
Mbarara National Referral Hospital
2014-2023
Infectious Diseases Institute
2022
World Health Organization - Uganda
2020
University of Washington
2016-2017
Background Antiretroviral-based interventions for HIV-1 prevention, including antiretroviral therapy (ART) to reduce the infectiousness of infected persons and pre-exposure prophylaxis (PrEP) susceptibility uninfected persons, showed high efficacy protection in randomized clinical trials. We conducted a prospective implementation study understand feasibility effectiveness these delivery settings. Methods Findings Between November 5, 2012, January 2015, we enrolled followed 1,013 heterosexual...
BackgroundCommunity-based delivery of antiretroviral therapy (ART) for HIV, including ART initiation, clinical and laboratory monitoring, refills, could reduce barriers to treatment improve viral suppression, reducing the gap in access care individuals who have detectable HIV load, men are less likely than women be virally suppressed. We aimed test effect community-based on suppression among people living with not ART.MethodsWe did a household-randomised, unblinded trial (DO ART) community...
<ns4:p><ns4:bold>Background</ns4:bold>: Pre-exposure prophylaxis (PrEP) can provide high protection against HIV infection and is a recommended intervention for HIV-negative persons with substantial risk. Demonstration projects conducted in diverse settings worldwide illustrate practical examples of how PrEP be delivered. This manuscript presents estimates effectiveness patterns use within two-year demonstration project members heterosexual serodiscordant couples East Africa.</ns4:p><ns4:p>...
Abstract Background Cipargamin (KAE609) is a potent antimalarial in phase II trial. Here we report efficacy, pharmacokinetics, and resistance marker analysis across range of cipargamin doses. These were secondary endpoints from study primarily conducted to assess the hepatic safety (hepatic data are reported elsewhere). Methods This II, multicenter, randomized, open-label, dose-escalation trial was sub-Saharan Africa adults with uncomplicated Plasmodium falciparum malaria. monotherapy given...
HIV testing is a key component of prevention and an entry point into HIV/AIDS treatment care however, coverage access to remains low in Uganda. Home-Based Counseling Testing (HBHCT) has potential increase early identification unknown disease. This study investigated the level acceptance (HBHCT), sero-prevalence factors associated with HBHCT urban setting. A cross-sectional house-to-house survey was conducted Rubaga division Kampala from January-June 2009. Residents aged ≥ 15 years were...
Introduction: Pre-exposure prophylaxis (PrEP) can provide high protection against HIV infection and is a recommended intervention for HIV-negative persons with substantial risk, such as individuals partner living HIV. Demonstration projects of PrEP have been conducted in diverse settings worldwide to illustrate practical examples how be delivered. Methods: We evaluated delivery partners within heterosexual serodiscordant couples an open-label demonstration project East Africa. The model...
Abstract Introduction: Adherence is essential for pre‐exposure prophylaxis (PrEP) to protect against HIV acquisition, but PrEP use need not be life‐long. most efficient when its aligned with periods of risk – a concept termed prevention‐effective adherence. The objective this paper describe adherence and predictors within an open‐label delivery project integrated antiretroviral therapy (ART) among serodiscordant couples in Kenya Uganda (the Partners Demonstration Project). Methods : We...
The success of universal antiretroviral therapy (ART) access and aspirations for an AIDS-free generation depend on high adherence in individuals initiating ART during early-stage HIV infection; however, may be difficult the absence illness associated support.From March 2015 to October 2017, we prospectively observed three groups routine care Uganda South Africa: men non-pregnant women with infection (CD4 > 350 cells/μL), pregnant late-stage < 200 cells/μL). Socio-behavioural questionnaires...
Oral pre-exposure prophylaxis (PrEP) is effective for HIV prevention, and PrEP delivery studies are investigating ways to deliver with high adherence. However, in many settings burden, intimate partner violence (IPV) reported often could be a barrier the use. We examined association between IPV interruptions use.We analyzed data from 1013 serodiscordant heterosexual couples enrolled large demonstration project Kenya Uganda, Partners Demonstration Project. At quarterly study visits,...
Physical Activity (PA) and its links to frailty, quality of life (QoL), other comorbidities in older Ugandans living with HIV remain under-explored. We analyzed data from three annual assessments people (PLWH) age- sex-similar not (PnLWH). fitted linear generalized estimating equations (GEE) regression models estimate the correlates PA, including demographics, QoL, HIV, comorbidities. enrolled 297 PLWH 302 PnLWH. Older age (b = -157.34, 95% CI [-222.84, -91.83]), -979.88 [95% CI: -1878.48,...
Abstract Use of herbal medicines among patients receiving Anti-retroviral Therapy (ART) remains by far an uncharacterised phenomenon in Africa and Uganda specifically. We evaluated the use on ART at HIV clinic Mbarara Regional Referral Hospital (MRRH), examined factors associated with their concomitant impact adherence. This was a cross-sectional study 334 systematically sampled MRRH from February to April 2010. collected data patient demographics, clinical characteristics, perceptions...
Achieving the UNAIDS goals of 90-90-90 will require more than doubling number people accessing HIV care in Uganda. Community-based programmes for entry into are effective strategies to expand access care, but few have been evaluated with a particular focus on scale-up.
Pre-exposure prophylaxis (PrEP) to prevent HIV infection is being rolled out in Africa. The uptake of PrEP date has varied across populations and locations. We seek understand the drivers demand for through analysis qualitative data collected conjunction with a demonstration project involving East African serodiscordant couples. Our goal was inform creation by understanding what means - beyond prevention lives users.The Partners Demonstration Project evaluated an integrated strategy...
In sub-Saharan Africa (SSA), antiretroviral therapy (ART) can prolong life for HIV-infected patients. However, patients initiating ART, especially in routine treatment programs, commonly dropout from care either due to death or loss follow-up. a cohort of ART at public sector clinic Uganda, we assessed predictors (a composite outcome combining and follow-up). From large set socio-demographic, clinical, laboratory variables routinely collected initiation, selected those predicting P <0.1...
Background: Global guidelines recommend preexposure prophylaxis (PrEP) use by women at risk for HIV, including during pregnancy, a period with heightened HIV risk. However, data to support safety of PrEP pregnancy are limited, particularly from using throughout pregnancy. Methods: In an open-label delivery study integrated ART high-risk serodiscordant couples in Kenya and Uganda (the Partners Demonstration Project), who became pregnant while were offered the option continue We compared...
Pregnancy is a time of increased HIV acquisition risk and pregnancy reduces concentrations antiretrovirals used for treatment. We assessed whether lowers tenofovir (TFV) tenofovir-diphosphate (TFV-DP) among HIV-uninfected women using oral preexposure prophylaxis (PrEP).We analyzed data from an open-label PrEP study, comparing TFV in plasma TFV-DP dried blood spots (DBS) 37 pregnant 97 nonpregnant women. Analyses controlled adherence daily electronic monitoring.The average concentration was...
Timely initiation of and adherence to antiretroviral therapy (ART) is critical for improving HIV outcomes reducing transmissibility. Social networks, or the social relationships individuals have with each other, been linked positive health outcomes, but less known about extent which network composition structure are associated improved ART among people living (PLWH). We conducted an ego-centric study 828 previously ART-naïve PLWH presenting at 11 clinics in Mbarara, Uganda (rural population)...
ObjectiveTo examine the patterns of COVID-19 transmission in Uganda.MethodsWe reviewed ten weeks press releases from Uganda Ministry Health day when first case was announced, March 22, through May 29, 2020. We obtained MoH website and Twitter handle (@MinofHealthUG). Data include number persons tested categories were classified as international arrivals, community members, long-distance truck drivers.ResultsThe cases arrivals Asia Europe, after that, emerged. However, middle April 2020,...
Antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) reduce HIV-1 transmission within heterosexual serodiscordant couples. Prioritizing couples at highest risk for ART PrEP would maximize impact minimize costs.The Partners Demonstration Project is an open-label, delivery study of integrated prevention among high in Kenya Uganda. We evaluated the feasibility using a validated score that weighs combination easily measurable factors (age, children, marital status, male circumcision...
The successes of HIV treatment scale-up and the availability new prevention tools have raised hopes that epidemic can finally be controlled ended. Reduction in incidence control requires high testing rates at population levels, followed by linkage to or prevention. As effective strategies are identified, it becomes important understand how these work. We use qualitative data from Linkages Study, a recent community intervention trial community-based with interventions sub-Saharan Africa, show...
Abstract Introduction We conducted a cohort study to understand patterns of anti‐retroviral therapy (ART) adherence during pregnancy, postpartum and non‐pregnancy follow‐up among women initiating ART in public clinics offering Option B+ rural Uganda urban South Africa. Methods collected survey data, continuously monitored (Wisepill), HIV‐RNA pregnancy tests at zero, six twelve months from Africa, 2015 2017. The primary predictor interest was time categorized as pregnant (pregnancy diagnosis...