A5091434117- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- HIV, Drug Use, Sexual Risk
- Sirtuins and Resveratrol in Medicine
- Neonatal Health and Biochemistry
- HIV/AIDS drug development and treatment
- Neonatal and fetal brain pathology
- Adolescent Sexual and Reproductive Health
- Cytomegalovirus and herpesvirus research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Herpesvirus Infections and Treatments
- Diabetes Treatment and Management
- Infant Development and Preterm Care
- Sex work and related issues
- Lipid metabolism and disorders
- Autophagy in Disease and Therapy
- Diet, Metabolism, and Disease
- Global Health and Epidemiology
- Gestational Diabetes Research and Management
- Curcumin's Biomedical Applications
- Coronary Interventions and Diagnostics
- Global Maternal and Child Health
- Diabetes Management and Research
Sun Yat-sen University
2020-2024
First Affiliated Hospital of Wannan Medical College
2024
Wannan Medical College
2024
Shanghai Chest Hospital
2021-2023
Information Technology Institute
2023
Chinese Academy of Sciences
2023
University of Chinese Academy of Sciences
2023
Institute of Semiconductors
2023
Shanghai Jiao Tong University
2018-2022
University of Washington
2012-2021
Background Bacterial vaginosis (BV), a disruption of the normal vaginal flora, has been associated with 60% increased risk HIV-1 acquisition in women and higher concentration RNA genital tract HIV-1–infected women. However, whether BV, which is present up to half African women, an increase transmission male partners not assessed previous studies. Methods Findings We association between BV on female-to-male prospective study 2,236 HIV-1–seropositive their uninfected from seven countries...
For antiretroviral therapy (ART) to have a population-level HIV prevention impact, high levels of testing and effective linkages care among HIV-infected persons are required.
Antiretroviral preexposure prophylaxis (PrEP), using tenofovir disoproxil fumarate (TDF) and combination emtricitabine/tenofovir (FTC+TDF), is efficacious for prevention of human immunodeficiency virus (HIV) acquisition. PrEP could reduce periconception HIV risk, but the effect on pregnancy outcomes not well defined.To assess incidence among women during period.Randomized trial 1785 HIV-serodiscordant heterosexual couples (the Partners Study) in which female partner was uninfected that...
<ns4:p><ns4:bold>Background</ns4:bold>: Pre-exposure prophylaxis (PrEP) can provide high protection against HIV infection and is a recommended intervention for HIV-negative persons with substantial risk. Demonstration projects conducted in diverse settings worldwide illustrate practical examples of how PrEP be delivered. This manuscript presents estimates effectiveness patterns use within two-year demonstration project members heterosexual serodiscordant couples East Africa.</ns4:p><ns4:p>...
Introduction: Pre-exposure prophylaxis (PrEP) can provide high protection against HIV infection and is a recommended intervention for HIV-negative persons with substantial risk, such as individuals partner living HIV. Demonstration projects of PrEP have been conducted in diverse settings worldwide to illustrate practical examples how be delivered. Methods: We evaluated delivery partners within heterosexual serodiscordant couples an open-label demonstration project East Africa. The model...
Facility- and community-based efforts to improve human immunodeficiency virus (HIV) testing in sub-Saharan Africa may benefit from understanding how mental health influences HIV care-seeking behavior.
Protection of cardiomyocytes against oxidative stress is vital to alleviate myocardial ischemia/reperfusion injury (MI/RI). However, antioxidative treatment hampered by the lack safe and effective therapeutics. Polydopamine (PDA), as a biodegradable class nanomaterial with excellent antioxidant properties, has shown great potential in treating MI/RI. To achieve site-specific efficacy, we established PDA-based biomimetic nanoplatform (PDA@M), which consisted polydopamine core macrophage...
Original Research1 July 2014Daily Oral Tenofovir and Emtricitabine–Tenofovir Preexposure Prophylaxis Reduces Herpes Simplex Virus Type 2 Acquisition Among Heterosexual HIV-1–Uninfected Men WomenA Subgroup Analysis of a Randomized TrialConnie Celum, MD, MPH, Rhoda A. Morrow, PhD, Deborah Donnell, Ting Hong, Craig W. Hendrix, Katherine K. Thomas, MS, Kenneth H. Fife, Edith Nakku-Joloba, MBChB, Andrew Mujugira, Jared M. Baeten, for the Partners PrEP Study Team*Connie MPHFrom University...
Transiently low levels of thyroid hormones occur in approximately 50% neonates born 24-28 weeks' gestation and are associated with higher rates cerebral palsy cognitive impairment. Raising hormone shows promise for improving neurodevelopmental outcome.
Background: There is an urgent need for more accurate screening tests tuberculosis (TB). We assessed the diagnostic accuracy of C-reactive protein (CRP) as a test active TB in HIV-infected ambulatory adults. Methods: CRP levels were measured blood collected at time HIV testing. Diagnostic pulmonary was calculated (reference standard: culture), compared to WHO 4-symptom screen, consisting cough, fever, night sweats, and weight loss. also larger cohort adults with positive symptom screen...
Aims. To explore the relationship between gestational diabetes mellitus (GDM) and neonatal cord blood amino acid carnitine levels after GDM was diagnosed among pregnant women monitoring glycosylated haemoglobin of 5.5%-6.4% during mid-late gestation. Methods. In all, 7289 qualified participants were recruited divided into two groups (GDM control groups) 1 July 2015 2020, all maternal-neonatal data collected analyzed at three centers. Results. Interestingly, glycine in not only significantly...
Acute myocardial infarction (AMI) is usually caused by coronary thrombosis. However, the short half-life, lack of targetability and inevitable ischemia/reperfusion injury secondary to revascularization, which characterizes tissue plasminogen activator (tPA) limit its thrombolytic efficacy for AMI. To address targeted site-specific delivery tPA, current study reports construction a thrombus-targeting responsive biomimetic nanoparticle (PTPN) spatiotemporal treatment PTPN was constituted...
Background: Global guidelines recommend preexposure prophylaxis (PrEP) use by women at risk for HIV, including during pregnancy, a period with heightened HIV risk. However, data to support safety of PrEP pregnancy are limited, particularly from using throughout pregnancy. Methods: In an open-label delivery study integrated ART high-risk serodiscordant couples in Kenya and Uganda (the Partners Demonstration Project), who became pregnant while were offered the option continue We compared...
Curcumin is a polyphenol that has been shown to have prebiotic and cholesterol-lowering properties. This study aimed investigate the impact of curcumin on bile cholesterol supersaturation potential mechanistic role intestinal microbiota absorption. Male hamsters (n = 8) were fed high-fat diet (HFD) supplemented with or without for 12 weeks. Results showed significantly decreased levels in serum (from 5.10 4.10 mmol/L) liver 64.60 47.72 nmol/mg protein) HFD-fed reduced saturation index (CSI)...
Background Sepsis-induced cardiomyopathy ( SIC ) is one major cause of death for sepsis but lacks timely diagnosis and specific treatment due to unclear mechanisms. Lipocalin-2 (LCN-2) a key regulator lipid metabolism which has been recently proved closely related sepsis, however, the relationship between LCN-2 septic myocardial injury remains unknown. We aim explore role in pathological progress based on clinical laboratory evidence. Methods Consecutive patients admitted intensive care unit...
Curcumin is a polyphenol extracted from the rhizome of turmeric, and our previous research showed that curcumin inhibited cholesterol absorption had cholesterol-lowering effect. Bisphenol A (BPA), common plasticizer, widely used in manufacture food packaging associated with non-alcoholic fatty liver disease (NAFLD). We hypothesized could protect against BPA-induced hepatic steatosis by inhibiting synthesis. Male CD-1 mice fed BPA-contaminated diet or without for 24 weeks were to test...
Abstract Erythropoietin (EPO) has beneficial effects on glucose metabolism and insulin resistance. However, the mechanism underlying these not yet been elucidated. This study aimed to investigate how EPO affects hepatic metabolism. Here, we report that administration promoted phosphatidylinositol 3-kinase (PI3K)/AKT pathway activation in palmitic acid (PA)-treated HepG2 cells liver of high-fat diet (HFD)-fed mice, whereas adenovirus-mediated silencing erythropoietin receptor (EPOR) blocked...