A5068425759- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Cardiac Ischemia and Reperfusion
- Conducting polymers and applications
- Plant Virus Research Studies
- Trauma Management and Diagnosis
- Advanced biosensing and bioanalysis techniques
- Antibiotic Resistance in Bacteria
- Nonlinear Partial Differential Equations
- Pleural and Pulmonary Diseases
- Covalent Organic Framework Applications
- Biopolymer Synthesis and Applications
- Innovations in Medical Education
- Viral Infections and Immunology Research
- Toxin Mechanisms and Immunotoxins
- Blood disorders and treatments
- Plant-based Medicinal Research
- IL-33, ST2, and ILC Pathways
- Inflammatory mediators and NSAID effects
- Pneumocystis jirovecii pneumonia detection and treatment
- Natural product bioactivities and synthesis
- Curcumin's Biomedical Applications
- Inflammation biomarkers and pathways
- Cardiac, Anesthesia and Surgical Outcomes
- Animal Virus Infections Studies
Shanghai Chest Hospital
2021-2025
Shanghai Jiao Tong University
2021-2025
Shangrao Normal University
2023
China Pharmaceutical University
2022
Jiangmen Central Hospital
2019
Guizhou Institute of Technology
2013
Zhongshan Hospital
2007-2010
Shanghai Medical College of Fudan University
2010
Taizhou Municipal Hospital
2009
The First Affiliated Hospital, Sun Yat-sen University
2007
Cardiac troponin I (cTnI) is an extremely sensitive biomarker for early indication of acute myocardial infarction (AMI). However, it still remains a tough challenge many newly developed cTnI biosensors to achieve superior sensing performance including high sensitivity, rapid detection, and resistance interference in clinical serum samples. Herein, novel photocathodic immunosensor toward has been successfully by designing unique S-scheme heterojunction based on the porphyrin-based covalent...
Protection of cardiomyocytes against oxidative stress is vital to alleviate myocardial ischemia/reperfusion injury (MI/RI). However, antioxidative treatment hampered by the lack safe and effective therapeutics. Polydopamine (PDA), as a biodegradable class nanomaterial with excellent antioxidant properties, has shown great potential in treating MI/RI. To achieve site-specific efficacy, we established PDA-based biomimetic nanoplatform (PDA@M), which consisted polydopamine core macrophage...
Acute myocardial infarction (AMI) is a leading cause of death and disability worldwide. MicroRNA-133a (miRNA-133a) serves as valuable biomarker for AMI, offering specificity stability an early diagnosis. However, existing miRNA biosensors faced challenges in detecting low concentrations, ensuring accuracy, maintaining immunity to interference. This study presents novel 1D/2D bismuth vanadium oxide (BiVO4) copper-tetraphenylporphyrin (Cu-TCPP) metal-organic framework heterojunction,...
A simple-structured photoelectrochemical immunosensor was constructed from polydopamine and silicon nanowire arrays. This type of sensor facilitates rapid detection troponin I.
Bronchopleural fistula (BPF) is a relatively rare postoperative complication with high mortality. The management tough and controversial. aim of this study was to compare the short long-term outcomes between conservative interventional therapy in BPF. We also concluded our own strategy experience treatment BPF.Postoperative BPF patients malignancies, aged from 18 80 years old who had undergone thoracic surgery June 2011 2020, were included followed up 20 months 10 years. They retrospectively...
The involvement of cardiomyopathy during sepsis means higher mortality and prolonged length hospital stay. Many efforts have been made to alleviate the apoptosis cardiomyocytes in sepsis. huge potential IL-13 tissue repair has attracted increasing attention. In present study, we used LPS-treated mice or primary as a model explore anti-apoptotic ability IL-13. It was found that an increased level exogenous beneficial recovery heart function sepsis, this effect probably through enhancing...
The current study aimed to investigate the incidence of sepsis-induced cardiomyopathy (SICM) in patients who received general thoracic surgery, along with risk factors and management strategies for this complication.The clinical records 163 postoperative sepsis were retrospectively reviewed. After propensity score matching, 144 divided into 2 groups by stroke volume: SICM group (n=72) non-SICM (n=72).The overall was 53.99%. Multiple logistic regression analysis showed that volume C-reactive...
Although tacrolimus has been widely used in patients undergoing lung transplantation, few studies have reported the pharmacokinetics of Chinese after transplantation. Thus, we aimed to investigate and influential factors this patient cohort early stage transplantation.We enrolled 14 adult transplant recipients who were treated with then intensively collected blood samples within a 12-h dosing interval. The pharmacokinetic parameters calculated using non-compartmental analysis, influence...
Abstract Purpose Donor-derived infection (DDI) has become an important factor affecting the prognosis of lung transplantation patients. The risks versus benefits using donor organs infected with multidrug-resistant organisms (MDRO), especially carbapenem-resistant (CRO), are frequently debated. Traditional microbial culture and antimicrobial susceptibility testing at present fail to meet needs quick CRO determination for lungs before acquisition. In this study, we explored a novel screening...
Utilization rate of donor lungs in China is constrained by the inefficiency conventional cold preservation (COLD) lung transplantation. We assessed performance normothermic ex vivo perfusion (EVLP) donors following cardiac death (DCD) with fresh EVLP perfusate.A total 24 adult Sprague-Dawley (SD) rats were randomized into three groups (EVLP, COLD, and control groups) 8 each. Fresh perfusate was prepared for perfusion. The pH, electrolyte concentration, penetration pressure during irrigation,...
Both curcumin and naproxen possess the activity of pain relief, which makes it possible to co-administrate these drugs in same prescription. This study aimed assess potential pharmacokinetic interaction with rats. Sprague-Dawley (SD) rats were orally administrated (10 mg/kg body weight) or 20 mg/kg, synchronously successively a single administration as control group. The plasma concentration was analyzed liquid chromatography tandem mass spectrometry concentration-time curve established...
Abstract Purpose: Donor-derived infection (DDI) has become an important factor affecting the prognosis of lung transplantation patients. The risks versus benefits using donor organs infected with multidrug-resistant organisms (MDRO), especially carbapenem-resistant Enterobacterales (CRE), are frequently debated. Traditional microbial culture and antimicrobial susceptibility testing at present fail to meet needs quick CRE determination for before acquisition. In this study, we explored a...
Obliterative bronchiolitis (OB) is the major complication affecting long-term survival of post-lung transplantation patients. In this study, we evaluated efficacy Tk-PQ (a peptide derived from trichosanthin) in alleviating OB a mouse ectopic tracheal transplant model. We found that post-transplantation treatment significant ameliorated symptoms including decreased luminal occlusion, reduced epithelial cells loss and less fibrosis allograft. Further, caused an immune suppressive environment...
This study aimed to identify the phytochemical constituents that could target gastric cancer in Kangai injection using a network pharmacology-based approach.Protein-protein interactions (PPI), Gene Ontology, and Kyoto Encyclopedia of Genes Genomes (KEGG) pathway enrichment analysis were conducted utilizing String OmicShare tools. In vitro experiments, related mRNA protein levels assessed via real-time quantitative polymerase chain reaction Western blotting, respectively. Cell proliferation...
Objective To evaluate the diagnostic value of surface enhanced laser desorption/ionization time flight mass spectrom-etry(SELDI-TOF-MS) for Paget disease. Methods The relative contents serum proteins 15 healthy people,15 patients with chronic eczema and 20 were detected by Weak cation exchanger protein chip (WCx2) SELDI-TOF-MS. Results con-tents two (3868Da,8876Da) had significant difference in people disease patients(P<0.01). 291IDa, 3868Da 5097Da peaks disease(P<0.05). Conclusion It shows...
Objective To explore the application effect of outcome-based education model in clinical teaching for neurosurgery nursing students. Methods By convenience sampling, students on placement rotation Department Neurosurgery Nanfang Hospital Southern Medical University from August 2016 to July 2017 were selected and assigned into control group (n=55) , those 2018 put observation (n=51) . According requirements curriculum, traditional method was adopted group, basis that, group. The two...
Abstract Although tacrolimus has been widely used in patients undergoing lung transplantation, few studies have reported the pharmacokinetics of Chinese after transplantation. Thus, we aimed to investigate its and influential factors this patient cohort early stage We enrolled 14 transplant recipients who were treated with voriconazole. then collected intensive blood samples within a 12-hour dosing interval analysed them via liquid chromatography-mass spectrometry. The pharmacokinetic...