A5101411890- Antiplatelet Therapy and Cardiovascular Diseases
- Congenital heart defects research
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Congenital Heart Disease Studies
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Lung Cancer Diagnosis and Treatment
- Cardiac pacing and defibrillation studies
- Lipoproteins and Cardiovascular Health
- Cardiac electrophysiology and arrhythmias
- Pulmonary Hypertension Research and Treatments
- Tracheal and airway disorders
- Diabetes Treatment and Management
- Receptor Mechanisms and Signaling
- RNA Research and Splicing
- Galectins and Cancer Biology
- Atherosclerosis and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- IL-33, ST2, and ILC Pathways
- Gold and Silver Nanoparticles Synthesis and Applications
- Extracellular vesicles in disease
- Adipokines, Inflammation, and Metabolic Diseases
- Hormonal Regulation and Hypertension
Shanghai Jiao Tong University
2014-2025
Shanghai Chest Hospital
2014-2025
Institute of Cardiology
2018
Tongji University
2011
National University Hospital
2007-2008
Fudan University
2004
University of Chicago
1994
May Institute
1994
Hydrogen therapy has shown new potential in cancer treatment, particularly high-pressure and hypoxic areas, where it demonstrates the ability to alter tumor microenvironment regulate metabolism. disrupts mitochondrial function of cells, interferes with their energy metabolism, ultimately leads depletion apoptosis. In this study, a sonocatalyst (BPM), is designed generate hydrogen oxygen situ within tumors, further enhancing therapeutic efficacy. The mesocrystalline structure BPM, composed...
Protection of cardiomyocytes against oxidative stress is vital to alleviate myocardial ischemia/reperfusion injury (MI/RI). However, antioxidative treatment hampered by the lack safe and effective therapeutics. Polydopamine (PDA), as a biodegradable class nanomaterial with excellent antioxidant properties, has shown great potential in treating MI/RI. To achieve site-specific efficacy, we established PDA-based biomimetic nanoplatform (PDA@M), which consisted polydopamine core macrophage...
Rapid and accurate detection of myocardial infarction (MI) can boost the patient's chance survival. Surface enhanced Raman scattering (SERS) is an outstanding diagnostic technique because its strong light stability, high resolution, qualitative quantitative analysis based on characteristic fingerprint. However, reliability, stability specificity remain to be improved, especially in serum samples. In this study, we developed situ silver nanoparticles (Ag NPs) surface polydopamine (PDA) as a...
Abstract Engineering of materials is crucial for the advanced detection bio‐molecules, particularly in laser desorption/ionization mass spectrometry (LDI‐MS). However, effective screening with enhanced LDI performance remains challenging due to lack engineered substrate materials. Herein, thermally ferric yolk‐shells are designed metabolic cervical cancer (CC) using vaginal secretion. A facile thermal engineering strategy developed prepare amorphous integrated properties. Notably, mesoporous...
The cardiac T-box transcription factor TBX5 is crucial for proper cardiovascular development, and mutations in have been associated with various congenital heart diseases arrhythmias humans. However, whether mutated contributes to dilated cardiomyopathy (DCM) remains unclear. In this study, the coding exons flanking introns of gene were sequenced 190 unrelated patients idiopathic DCM. available family members index patient carrying an identified mutation 200 ethnically matched healthy...
Congenital heart disease (CHD) is the most common developmental abnormality, and leading noninfectious cause of mortality in neonates. Increasing evidence demonstrates that genetic defects play an important role pathogenesis CHD. However, CHD exhibits substantial heterogeneity, determinants for remain unknown overwhelming majority cases. In current study, coding exons flanking introns HAND2 gene, which encodes a basic helix-loop-helix transcription factor essential normal cardiovascular...
Left bundle branch area pacing (LBBAP) includes left (LBBP) and ventricular (LV) septal myocardial (LVSP).The study aimed to assess resynchronization effects clinical outcomes by LBBAP in heart failure (HF) patients with cardiac therapy (CRT) indications.LBBAP was successfully performed 29 consecutive further classified as the LBBP-group (N = 15) LVSP-group 14) based on LBBP criteria novel LV conduction time measurement (LV CT, between site (LVP) site). AV-interval optimized or LVSP, LVSP...
Abstract Current ablation strategies for persistent atrial fibrillation (AF) remain suboptimal, with success rates around 50%. Pulmonary vein isolation (PVI) serves as the cornerstone of ablation, yet adjunctive have shown inconsistent results in randomized controlled trials. This review critically examines outcomes and limitations these approaches while identifying key barriers to success, including incomplete understanding AF mechanisms, patient heterogeneity, technical challenges...
Current guidelines for the optimal ablation strategy persistent atrial fibrillation(PerAF) remain unclear. While our previous RCT confirmed favorable prognosis of aggressive ablation, real-world evidence is still lacking. Among 4,833 PerAF patients undergoing catheter at 10 centers, two groups were defined: Regular Ablation(PVI-only or PVI plus anatomical ablation) and Aggressive Ablation(anatomical electrogram-guided ablation), with 1,560 each after propensity score(PS) matching. The...
Cardiac dysfunction is a serious complication of sepsis-induced multiorgan failure in intensive care units and characterized by an uncontrolled immune response to overwhelming infection. Type 2 innate lymphoid cells (ILC2s), as part the system, play crucial role inflammatory process heterogeneous cardiac disorders. However, ILC2 regulating its underlying mechanism remain unknown. The present study demonstrated that autophagic flux blockage exacerbated dysfunction, which was associated with...
Protein de novo design is a longstanding challenge in biological field due to the multifaceted physicochemical properties and complexities of proteins. Several deep learning models have emerged for protein design. However, each model exhibits distinct strengths limitations because differences training strategies or neural network architectures. Therefore, improving effectiveness design, particularly functional protein, requires further improvement. To tackle this challenge, we developed...
ABSTRACT Background The evidence supporting additional linear ablation for persistent atrial fibrillation (PerAF) remains limited. This study investigates the mechanisms of intermediate tachycardia (AT), a transient state between PerAF and sinus rhythm (SR), during termination by catheter ablation, provides these mechanisms. Methods We analyzed 136 patients who converted to organized AT after in Extent‐AF study. Bi‐atrial activation mapping combined with entrainment was used identify...
Acute myocardial infarction (AMI) is a leading cause of death and disability worldwide. MicroRNA-133a (miRNA-133a) serves as valuable biomarker for AMI, offering specificity stability an early diagnosis. However, existing miRNA biosensors faced challenges in detecting low concentrations, ensuring accuracy, maintaining immunity to interference. This study presents novel 1D/2D bismuth vanadium oxide (BiVO4) copper-tetraphenylporphyrin (Cu-TCPP) metal-organic framework heterojunction,...
Acute myocardial infarction (AMI) is usually caused by coronary thrombosis. However, the short half-life, lack of targetability and inevitable ischemia/reperfusion injury secondary to revascularization, which characterizes tissue plasminogen activator (tPA) limit its thrombolytic efficacy for AMI. To address targeted site-specific delivery tPA, current study reports construction a thrombus-targeting responsive biomimetic nanoparticle (PTPN) spatiotemporal treatment PTPN was constituted...
Abstract Background: The zinc finger transcription factor CASZ1 plays a key role in cardiac development and postnatal adaptation, mice, deletion of the Methods: coding exons splicing junction sites Results: A novel heterozygous mutation, p.K351X, was identified an index patient with DCM. Genetic analysis mutation carrier’s family showed that co-segregated DCM, which transmitted autosomal dominant pattern complete penetrance. nonsense absent 400 referential chromosomes, altered amino acid...
Circular RNAs, a class of circularly closed non-coding play essential roles in the formation atherosclerosis, which is frequent cause cardiovascular and cerebrovascular diseases. Although many circular RNAs are found to be involved progression more RNA regulators still need identified, improve understanding regulatory networks atherosclerosis. Here, we that hsa_circ_0008896 was significantly up-regulated both vitro vivo atherosclerosis models, indicating Further functional analyses confirmed...
Congenital atrial septal defect (ASD) and progressive atriventricular block (AVB) are the two most common phenotypes linked to NK2 homeobox 5 (NKX2.5) mutations in animals humans. However, prevalence spectrum of NKX2.5 mutation patients with ASD AVB remain be elucidated. In present study, coding exons flanking introns gene, which encodes a homeobox‑containing transcription factor essential for development heart, were sequenced cohort 62 unrelated AVB, subsequently carrier's available family...
Previous genome-wide association studies have demonstrated that single nucleotide polymorphisms in T‑box (TBX)5 are associated with increased susceptibility to atrial fibrillation (AF), and a recent study has causally linked TBX5 mutation atypical Holt-Oram syndrome paroxysmal AF. However, the prevalence spectrum of mutations patients AF remain be elucidated. In present study, cohort 190 unrelated idiopathic were prospectively recruited, 400 healthy individuals recruited as controls. The...
Rapid and accurate detection of acute myocardial infarction can improve patients' chances survival. Cardiac troponin I (cTn I) is an important diagnostic biomarker for infarction. However, current immunoassays are insufficient to accurately measure cTn I, as they have limited sensitivity time-consuming. Surface-enhanced Raman scattering (SERS) a brilliant fingerprints technique characterised by ultrasensitivity, fast response, qualitative quantitative analysis capabilities. In this study,...