A5070752239- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Angiogenesis and VEGF in Cancer
- Ultrasound and Hyperthermia Applications
- Curcumin's Biomedical Applications
- Pulmonary Hypertension Research and Treatments
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Laser Applications in Dentistry and Medicine
- Lung Cancer Diagnosis and Treatment
- Sirtuins and Resveratrol in Medicine
- Photoacoustic and Ultrasonic Imaging
- Venous Thromboembolism Diagnosis and Management
- ECG Monitoring and Analysis
- Cancer Treatment and Pharmacology
- Phonocardiography and Auscultation Techniques
- Cancer-related molecular mechanisms research
- Cardiac Valve Diseases and Treatments
- Neurological disorders and treatments
- Bioactive natural compounds
- Protein Degradation and Inhibitors
- Ultrasound in Clinical Applications
- Neutropenia and Cancer Infections
- Pain Management and Treatment
Shanghai Jiao Tong University
2014-2025
Shanghai Chest Hospital
2016-2025
Guangzhou Medical University
2023-2024
First Affiliated Hospital of Guangzhou Medical University
2023-2024
Guangdong Pharmaceutical University
2019-2020
Zhongnan Hospital of Wuhan University
2018
Wuhan University
2018
XinHua Hospital
2013-2015
Huadong Hospital
2014
Fudan University
2014
Studies have demonstrated that curcumin (CUR) exerts its tumor suppressor function in a variety of human cancers including head and neck squamous cell carcinoma (HNSCC). However, the exact underlying molecular mechanisms remain obscure. Here, we aim to test whether CUR affects ATM/Chk2/p53 signaling pathway, leading induction cycle arrest, inhibition angiogenesis HNSCC vitro vivo. To this end, conducted multiple methods such as MTT assay, Invasion Flow cytometry, Western blotting, RT-PCR,...
Abstract SIRT1 is one of seven mammalian homologs Sir2 that catalyzes NAD + -dependent protein deacetylation. The aim the present study to explore effect small molecule activator on anticancer activity and underlying mechanism. We examined a novel oral agent, curcumin, which principal active ingredient traditional Chinese herb Curcuma Longa. Treatment FaDu Cal27 cells with curcumin inhibited growth induced apoptosis. Mechanistic studies showed associated decrease in migration HNSCC...
Left bundle branch area pacing (LBBAP) includes left (LBBP) and ventricular (LV) septal myocardial (LVSP).The study aimed to assess resynchronization effects clinical outcomes by LBBAP in heart failure (HF) patients with cardiac therapy (CRT) indications.LBBAP was successfully performed 29 consecutive further classified as the LBBP-group (N = 15) LVSP-group 14) based on LBBP criteria novel LV conduction time measurement (LV CT, between site (LVP) site). AV-interval optimized or LVSP, LVSP...
ABSTRACT Background Brugada syndrome (BrS) is associated with an electrocardiogram (ECG), but the causal relationship remains unclear. This study aimed to assess bidirectional between ECG parameters and BrS using Mendelian randomization (MR) analysis. Methods A MR analysis data from OpenGWAS database. Six parameters, including PR interval, PP ST duration, QRS T wave QT were included in forward as outcome. In reverse analysis, was exposure aforementioned outcomes. The inverse‐variance...
Rheumatic heart disease refers to the long-term damage of valves and results from an autoimmune response group A Streptococcus infection. This study aimed analyze microbiota composition patients with rheumatic explore potential function in this disease. First, we revealed significant alterations feces, subgingival plaques, saliva compared control subjects using 16S rRNA gene sequencing. Significantly different microbial diversity was observed all three types samples between subjects. In gut,...
The impairment in diabetic wound healing represents a significant clinical problem, with no efficient targeted treatments for these disorders. Curcumin is well confirmed to improve healing, however, its low bioavailability and poor solubility severely limit application. This study aims provide the pharmacological basis use of (2E,6E)-2,6-bis(2-(trifluoromethyl)benzylidene)cyclohexanone (C66). results showed that topically applied C66 improved cutaneous vivo. Further studies treatment...
In this work, we first investigated the effect of fructose 1,6-bisphosphate, which is sugar phosphorylated on carbons 1 and 6, biomineralization calcium carbonate, prepared carbonate/fructose 1,6-bisphosphate (CC/FBP) composite nanospheres. Then, transformation CC/FBP nanospheres under microwave-assisted hydrothermal conditions carbonated hydroxyapatite (CHA) porous We found that FBP has a unique morphology crystallization carbonate. can control carbonate provide phosphorus source for...