A5082764262- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Congenital heart defects research
- Advanced MRI Techniques and Applications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Congenital Heart Disease Studies
- Protein Tyrosine Phosphatases
- Venous Thromboembolism Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- Viral Infections and Immunology Research
- Metabolism, Diabetes, and Cancer
- Lysosomal Storage Disorders Research
- Glycogen Storage Diseases and Myoclonus
- Cardiovascular Health and Disease Prevention
- Diabetes Management and Research
- Trypanosoma species research and implications
- Cardiac tumors and thrombi
- Diet and metabolism studies
- Vascular Procedures and Complications
- Amyloidosis: Diagnosis, Treatment, Outcomes
Air Force Medical University
2014-2025
Xijing Hospital
2014-2025
National Institute of Mental Health and Neurosciences
2022
Yan'an University
2012-2021
First Affiliated Hospital of Xinjiang Medical University
2010
Xinjiang Medical University
2010
Patients with hypertrophic obstructive cardiomyopathy (HOCM) and drug-refractory symptoms outflow gradients have limited nonsurgical treatment options. The feasibility of percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) has been reported previously; however, procedural medium-term outcomes are unknown.To describe the safety PIMSRA in a large patient cohort HOCM.This was single-arm, open-label study patients HOCM. presenting to Xijing Hospital Xi'an, China, between October...
Objective The objective is to evaluate the 5-year follow-up results of percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) for hypertrophic obstructive cardiomyopathy (HOCM), including clinical status, electrocardiographic and echocardiographic characteristics. Methods 27 patients (age: 44.3±15.5 years; 67% men, 33% women) with severely symptomatic HOCM who underwent PIMSRA from October 2016 September 2017 were included. Their resting exercise stress echocardiography,...
Background Patients with drug-refractory non-obstructive hypertrophic cardiomyopathy (NOHCM) lack effective invasive treatment options. This study aimed to evaluate the safety and effectiveness of percutaneous intramyocardial septal radiofrequency ablation (PIMSRA, Liwen procedure) in patients NOHCM severe hypertrophy (≥28 mm). Method single-arm, open-label, prospective enrolled 20 adult between June 2017 2023. underwent PIMSRA were followed for a median 15 months. Outcomes included changes...
Abstract Background Systolic anterior motion (SAM) of the mitral valve is a hallmark feature hypertrophic obstructive cardiomyopathy (HOCM) and primary cause dynamic left ventricular outflow tract obstruction. This case report highlights an unusual presentation SAM associated with acute haemodynamic collapse. Case summary A 36-year-old male HOCM presented recurrent episodes syncope. After multidisciplinary evaluation, he underwent percutaneous intramyocardial septal radiofrequency ablation...
Hypertrophic cardiomyopathy (HCM) is the most common hereditary cardiovascular disease. In general, obstructive hypertrophic (HOCM) more closely related to severe clinical symptoms and adverse outcomes. Therefore, it necessary explore possible causes of HOCM, which may help physicians better understand disease effectively control manage progression recent years, discovery lactylation has provided scholars with a new direction occurrence diseases. diseases, this post-translational...
Abstract Background Light-chain (AL) amyloidosis is the most common type of systemic with poor prognosis. Currently, predictors cardiac involvement and prognostic staging systems are primarily based on conventional echocardiography serological biomarkers. We used three-dimensional speckle tracking (STE-3D) measurements strain, hypothesizing that it could detect aid in prediction mortality. Methods retrospectively analysed 74 consecutive patients biopsy-proven AL amyloidosis. Among them, 42...
Introduction: Calcium channel gene variations have been reported to be associated with hypertrophic cardiomyopathy (HCM) in family, but the relationship between calcium and HCM remains undefined population. Methods: A total of 719 unrelated patients were initially enrolled. Finally, 371 identified based on inclusion exclusion criteria, including 145 negative, 28 a single rare variation (calcium variation), 162 pathogenic/likely pathogenic sarcomere (sarcomere variation) 36 (double...
The triglyceride glucose (TyG) index has been considered a new biomarker for the diagnosis of angiocardiopathy and insulin resistance. However, association TyG with subclinical left ventricular (LV) systolic dysfunction still lacks comprehensive exploration. This study was carried out to examine this relationship in patients type 2 diabetes mellitus (T2DM).A total 150 T2DM preserved LV ejection fraction (LVEF ≥ 50%) from June 2021 December were included study. function evaluated through...
We aimed to examine the association between glycated hemoglobin (HbA1c), microvascular complications, and subclinical left ventricular (LV) systolic dysfunction, determine strength of correlation in asymptomatic patients with type 2 diabetes mellitus (T2DM).Global longitudinal strain (GLS) was employed assess LV function 152 enrolled T2DM preserved ejection fraction, cutoff for dysfunction predefined as GLS < 18%.According univariate analysis, reduced exhibited clinical features including...
Patients with cardiac tumors may present challenges for surgical resection due to poor clinical condition. Echocardiography-guided transapical radiofrequency ablation (TARFACT) potentially offers a less invasive palliative therapy option.
Objective Echocardiography-guided Percutaneous IntraMyocardial Septal Radiofrequency Ablation (PIMSRA, Liwen procedure) is a novel treatment option for hypertrophic obstructive cardiomyopathy (HOCM). The impact of PIMSRA on myocardial mechanics unknown. Methods Between October 2016 and June 2019, 3-dimentional speckle tracking echocardiography were performed in 82 patients. Echocardiographic imaging, qualitative quantitative clinical assessment completed at baseline, immediately...
Background Energy loss ( EL ) is a new quantitative hemodynamic index based on vector flow mapping VFM ). This study aimed to characterize of the left ventricle LV in healthy adults. Methods Fifty‐one adults were enrolled this study. was analyzed frame by using color Doppler images standard apical three‐chamber dynamic view an offline workstation. The average systole and diastole calculated, results averaged over three cardiac cycles. Results for 11.07±5.82J/m/s 11.58±5.54 J/m/s,...
Objectives This study sought to evaluate the clinical applicability of Liwen Liu RF™ ablation system for percutaneous intramyocardial septal radiofrequency (PIMSRA). Background Data on new cardiac devices treatment hypertrophic obstructive cardiomyopathy (HOCM) are limited. Materials and methods From July 2019 2020, a total 68 patients with drug-resistant HOCM, who underwent PIMSRA system, which has an electrode stepless adjustable length, were prospectively enrolled. Safety endpoints...
Objective. The purpose of this study was to evaluate the feasibility and safety myocardial biopsy using a new approach, Liwen procedure. Background. Myocardial is essential when other methods could not differentiate etiologies from hypertrophic obstructive cardiomyopathy (HOCM). Our previous work intramyocardial radiofrequency ablation for (Liwen procedure) may provide another approach obtain samples. Method. Seventeen patients with HOCM were enrolled biopsies through percutaneously accessed...
The purpose of this research was to assess the relationship between severity diabetic retinopathy (DR) and indexes left ventricle (LV) structure function in type 2 diabetes mellitus (T2DM). Retrospective analysis 790 patients with T2DM preserved LV ejection fraction. Retinopathy stages were classified as no DR, early nonproliferative moderate severe or proliferative DR. electrocardiogram used myocardial conduction function. Echocardiography evaluate Patients divided into three groups based...
Background Echocardiography-guided percutaneous intramyocardial alginate-hydrogel implantation (PIMAHI) is a novel treatment approach for heart failure (HF). We validated PIMAHI safety and efficacy in canine HF models. Methods Fourteen canines with [produced by coronary artery ligation, left ventricular ejection fraction (LVEF) &lt; 35%] were randomised to ( n = 8) or controls 6). Echocardiography, two-dimensional speckle tracking echocardiography, pathological examinations after 6-month...
Abstract Background Estimated plasma volume status (ePVS) estimated by the Duarte formula is associated with clinical outcomes in patients heart failure. It remains unclear predictive value of ePVS to postoperative hypotension (POH) percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) treating hypertrophic obstructive cardiomyopathy (HOCM). Methods Data HOCM who underwent PIMSRA were retrospectively collected. Preoperative was calculated using formulas which derived from...