Patients with heart failure are frequently hospitalized for fluid overload. A reliable method chronic monitoring of status is therefore desirable. We evaluated an implantable system capable measuring intrathoracic impedance to identify potential overload before hospitalization and determine the correlation between standard measures during hospitalization.Thirty-three patients NYHA class III IV were implanted a special pacemaker in left pectoral region defibrillation lead right ventricle....

Quantum interference (QI) of electron pathways has recently attracted increased interest as an enabling tool for single-molecule electronic devices. Although various molecular systems have been shown to exhibit QI effects and a number methods proposed its analysis, simple guidelines linking the structure in phase-coherent transport regime until now lacking. In present work we demonstrate that aromatic molecules is intimately related topology molecule’s π system establish graphical scheme...

Heart rate variability (HRV) as an indirect autonomic assessment provides prognostic information when measured over short time periods in patients with heart failure. Long-term continuous HRV can be from implantable device, but the clinical value of these measurements is unknown.A total 397 New York Association class III or IV failure were studied. Of these, 370 had their implanted cardiac resynchronization device for mortality risk stratification, and 288 parameters (ie, HRV, night rate,...

Background— The primary method for monitoring implantable cardioverter-defibrillator lead integrity is periodic measurement of impedance. Sprint Fidelis leads are prone to pace-sense fractures, which commonly present as inappropriate shocks caused by oversensing. Methods and Results— We developed tested an algorithm enhance early identification fractures reduce shocks. This lead-integrity algorithm, can be downloaded into presently implanted cardioverter-defibrillators, alerts the patient...

Ab initio calculations of cohesive properties, elastic constants, and phonon dispersions for ${\mathrm{CoSi}}_{2}$ were performed by means the Vienna ab molecular-dynamics package (VAMP), which makes use ultrasoft pseudopotentials. In addition, all-electron full-potential linearized augmented-plane-wave method was used calculation equilibrium properties as well constants derived from second derivatives total energies. For both methods, energies, their derivatives, related quantities are...

Background— The efficacy of cardiac resynchronization therapy (CRT) is associated with the amount CRT pacing delivered. specific causes loss and their relative frequencies remain poorly defined. Methods Results— patients who transmitted device data from 2006 to 2011 were screened for inclusion. Device diagnostics analyzed using an automated algorithm categorize into 10 different causes. was validated against manual adjudications a portion entire cohort. There 80 768 median time 594...

Besides active, functional molecular building blocks such as diodes or switches, passive components as, e.g., wires, are required to realize molecular-scale electronics. Incorporating metal centers in the backbone enables energy levels be tuned respect Fermi of electrodes. Furthermore, by using more than one center and sp-bridging ligands, a strongly delocalized electron system is formed between these metallic "dopants", facilitating transport along backbone. Here, we study influence...

Abstract Azulene (Az) is a non‐alternating, aromatic hydrocarbon composed of five‐membered, electron‐rich and seven‐membered, electron‐poor ring; an electron distribution that provides intrinsic redox activity. By varying the attachment points two electrode‐bridging substituents to Az center, influence functionality on charge transport evaluated. The conductance 1,3 derivative at least one order magnitude lower than those 2,6 4,7 derivatives, in agreement with density functional theory (DFT)...

BACKGROUND: Left bundle branch area pacing (LBBAP) may be an alternative to biventricular (BVP) for cardiac resynchronization therapy (CRT). We sought compare the acute hemodynamic and ECG effects of LBBAP, BVP, left bundle-optimized CRT (LOT-CRT) in candidates with advanced conduction disease. METHODS: In this multicenter study, 48 patients either nonspecific interventricular delay (n=29) or block (n=19) underwent testing determine change ventricular pressure maximal first derivative (LV d...

Microphone arrays with fixed (time-invariant) weights are directed at enhancing a desired signal from one direction (straight ahead) while attenuating spatially distributed interference and reverberation. Using the theory of sensitivity-constrained optimal beamforming [Cox et al., IEEE Trans. Acoust. Speech Sig. Process. ASSP-34, 393–398 (1986)], free-field head-sized extents were studied. The key parameters affecting array design performance set transfer functions target to each microphone...

The alignment of the Fermi level a metal electrode within gap hi ghest occupied (HOMO) and lowest unoccupied orbital (LUMO) molecule is key quantity in molecular electronics, which can vary electron transparency single junction by orders magnitude. We present quantitative analysis relation between this (which be estimated from charging free molecules) charge transfer for bipyridine biphenyl dithiolate (BPDT) molecules attached to gold leads based on density functional theory calculations....

Stable, single-molecule conducting-bridge configurations are typically identified from peak structures in a conductance histogram. In previous work on Pt with H2 at cryogenic temperatures it has been shown that near 1G0 identifies Pt-H2-Pt bridge. The histogram shows an additional structure lower not identified. Here, we show is likely due to hydrogen decorated chain contact the molecular

Destructive quantum interference (DQI) in single molecule electronics is a purely mechanical effect and entirely defined by the inherent properties of junction such as its structure symmetry. This definition DQI molecular alone suggests relation to other more general concepts chemistry well possibility deriving simple models for understanding device design. Recently, two have gained wide spread attention, where one was graphical scheme based on visually inspecting connectivity carbon sites...

Arterial diameter is an important parameter of vascular physiology in vivo. Noninvasive measurements arterial can be used the assessment endothelium-dependent vasoreactivity (EDV) and compliance. Measurements EDV may serve for early atherosclerosis. The potential value with specificity individual subjects a strong motivation improvements ultrasonic measurement diameter. This article presents evaluates new methods tracking from B-mode images. images acquired planes longitudinal to vessel...

The concept of single molecule rectifiers proposed in a theoretical work by Aviram and Ratner 1974 was the starting point now vibrant field molecular electronics. In meantime, built-in asymmetry conductance junctions has been reported at experimental level. this contribution, we present comparison three different types unimolecular rectifiers: (i) systems where donor acceptor parts molecules are taken from charge-transfer salt components; (ii) zwitterionic (iii) tour wires with nitro...

Quantum interference (QI) in molecular transport junctions can lead to dramatic reductions of the electron transmission at certain energies. In a recent work [Markussen et al., Nano Lett., 2010, 10, 4260] we showed how presence such nodes near Fermi energy be predicted solely from structure conjugated molecule when energies atomic pz orbitals do not vary too much. Here relax assumption equal on-site and generalize graphical scheme molecules containing different species. We use this...

In Stadler et al (2003 Nanotechnology 14 138), a scheme for molecular memory was presented. It based on the influence of positions chemical side-groups attached to aromatic molecules paths electrons propagating through these in ballistic and tunnelling transport regimes. Here we extend this concept following ways. (i) A graphical method is derived from an electron scattering formalism topological Huckel description, which allows us estimate whether between two electrodes specific atomic...

Inspired by recent measurements of forces and conductances bipyridine nanojunctions, we have performed density functional theory calculations structure electron transport in a molecule attached between gold electrodes for seven different contact geometries. The show that both the bonding force conductance are sensitive to surface structure, properties good agreement with experiment geometries characterized intermediate coordination metal atoms corresponding stepped surface. is mediated...

Asymmetric line shapes can occur in the transmission function describing electron transport vicinity of a minimum caused by quantum interference effects. Such asymmetry be used to increase thermoelectric efficiency molecular junctions. So far, however, asymmetric have been only empirically found for just few rather complex organic molecules where origins relation structure were not resolved. In present, work we introduce method analyze dependence dips from simple two site tight-binding...

Implantable loop recorders (ILR) have an automatic arrhythmia detection feature that can be compromised by inappropriately detected episodes. This study evaluated a new ILR sensing and scheme for automatically detecting asystole, bradyarrhythmia, tachyarrhythmia events, which is implemented in the next generation device (Reveal DX/XT).The employs adjusting R-wave threshold, enhanced noise rejection, algorithms to detect tachyarrhythmia. Performance of was using 2,613 previously recorded,...

The AdaptivCRT algorithm (aCRT) automatically adjusts atrioventricular delays each minute to achieve ventricular fusion through left (LV) or biventricular (BiV) pacing. aCRT is associated with superior clinical outcomes compared standard BiV pacing, but the association of and subsequent atrial fibrillation (AF) in a real-world population has not been fully evaluated.The purpose this study was investigate incidence AF ≥48 hours vs pacing after implant.Patients implanted cardiac...

Abstract The concept of molecular rectifiers introduced by Aviram and Ratner in 1974 has been the starting point field electronics possibility unimolecular rectification widely debated ever since. Despite large amount publications on this topic over years, physical mechanisms leading to phenomenon have not yet clarified where a systematic route for enhancing ratio (RR) molecules could be suggested. We present here theoretical study RR range with carboxylic group as bridge between π...