A5070903389- ECG Monitoring and Analysis
- HIV Research and Treatment
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- RNA and protein synthesis mechanisms
- HIV/AIDS drug development and treatment
- Biological Research and Disease Studies
- Gene expression and cancer classification
- Machine Learning in Bioinformatics
- Cardiovascular Syncope and Autonomic Disorders
- Healthcare Technology and Patient Monitoring
- Bioinformatics and Genomic Networks
- Genomics and Phylogenetic Studies
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- EEG and Brain-Computer Interfaces
- Non-Invasive Vital Sign Monitoring
- CRISPR and Genetic Engineering
- HIV/AIDS Research and Interventions
- Retinal Diseases and Treatments
Medtronic (United States)
2012-2024
Medtronic (Ireland)
2024
Northwestern University
2020
University of Minnesota
2012-2017
Children's Hospital at Montefiore
2015
Albert Einstein College of Medicine
2015
Johns Hopkins University
2012
College of Saint Benedict and Saint John's University
2010
Abstract Molecularly targeted therapies for advanced prostate cancer include castration modalities that suppress ligand-dependent transcriptional activity of the androgen receptor (AR). However, persistent AR signalling undermines therapeutic efficacy and promotes progression to lethal castration-resistant (CRPC), even when patients are treated with potent second-generation AR-targeted abiraterone enzalutamide. Here we define diverse genomic structural rearrangements ( -GSRs) as a class...
Background— The efficacy of cardiac resynchronization therapy (CRT) is associated with the amount CRT pacing delivered. specific causes loss and their relative frequencies remain poorly defined. Methods Results— patients who transmitted device data from 2006 to 2011 were screened for inclusion. Device diagnostics analyzed using an automated algorithm categorize into 10 different causes. was validated against manual adjudications a portion entire cohort. There 80 768 median time 594...
Non-small cell lung cancers (NSCLC) harbor thousands of passenger events that hide genetic drivers. Even highly recurrent in NSCLC, such as mutations PTEN, EGFR, KRAS, and ALK, are detected, at most, only 30% patients. Thus, many unidentified low-penetrant causing a significant portion cancers. To detect low-penetrance drivers forward screen was performed mice using the Sleeping Beauty (SB) DNA transposon random mutagen to generate tumors Pten-deficient background. SB coupled with Pten...
Human immunodeficiency virus type 2 (HIV-2) is often distinguished clinically by lower viral loads, reduced transmissibility, and longer asymptomatic periods than for human 1 (HIV-1). Differences in the mutation frequencies of HIV-1 HIV-2 have been hypothesized to contribute attenuated progression observed clinically. To address this hypothesis, we performed Illumina sequencing multiple amplicons prepared from cells infected with or HIV-2, resulting ~4.7 million read pairs identification...
Background: Central retinal artery occlusion (CRAO) causes sudden, irreversible blindness and is a form of acute ischemic stroke. In this study, we sought to determine the proportion patients in whom atrial fibrillation (AF) detected by extended cardiac monitoring after CRAO. Methods: We performed retrospective, observational cohort study using data from Optum deidentified electronic health record 30.8 million people cross-referenced with Medtronic CareLink database 2.7 devices situ....
Summary Summary: To conduct an independent secondary analysis of a multi-focal intervention for early detection sepsis that included implementation change management strategies, electronic surveil-lance sepsis, and evidence based point care alerting using the POC AdvisorTM application. Methods: Propensity score matching was used to select subsets cohorts with balanced covariates. Bootstrapping performed build distributions measured difference in rates/ means. The effect evaluated all...
Atrial fibrillation (AF) events in cardiac implantable electronic devices (CIEDs) are temporally associated with stroke risk. This study explores temporal differences AF burden HF hospitalization risk patients CIEDs.
Abstract Introduction Not all patients experience debilitating symptoms during Atrial Fibrillation (AF), some are asymptomatic. The reasons for this inter‐ and intrasubject variability is unknown. Purpose study objective was NOAH characterize episode‐level clinical characteristics associated with symptomatic versus asymptomatic episodes of AF in an implantable cardiac monitor (ICM). Methods Patients episode detected on ICM between 2007 2021 overlapping data from aggregated Electronic Health...
Histiocytic sarcoma is a rare, aggressive neoplasm that responds poorly to therapy. thought arise from macrophage precursor cells via genetic changes are largely undefined. To improve our understanding of the etiology histiocytic we conducted forward screen in mice using Sleeping Beauty transposon as mutagen identify drivers sarcoma. mutagenesis was targeted myeloid lineage Lysozyme2 promoter. Mice with activated had significantly shortened lifespan and majority these developed tumors...
5-Azacytidine (5-aza-C) is a ribonucleoside analog that induces the lethal mutagenesis of human immunodeficiency virus type 1 (HIV-1) by causing predominantly G-to-C transversions during reverse transcription. 5-Aza-C could potentially act primarily as ribonucleotide (5-aza-CTP) or deoxyribonucleotide (5-aza-2'-deoxycytidine triphosphate [5-aza-dCTP]) In order to determine primary form 5-aza-C active against HIV-1, Illumina sequencing was performed using proviral DNA from cells treated with...
Decitabine has previously been shown to induce lethal mutagenesis of human immunodeficiency virus type 1 (HIV-1). However, the factors that determine susceptibilities individual sequence positions in HIV-1 decitabine have not yet defined. To investigate this, we performed Illumina high-throughput sequencing multiple amplicons prepared from proviral DNA was recovered decitabine-treated cells infected with HIV-1. We found induced an ≈4.1-fold increase total mutation frequency HIV-1, primarily...
Atrial fibrillation (AF) outcomes are strongly associated with continuous measures of AF burden.
Abstract Background Personal genome assembly is a critical process when studying tumor genomes and other highly divergent sequences. The accuracy of downstream analyses, such as RNA-seq ChIP-seq, can be greatly enhanced by using personal genomic sequences rather than standard references. Unfortunately, reads sequenced from these types samples often have heterogeneous mix various subpopulations with different variants, making extremely difficult existing tools. To address challenges, we...
Multiple studies have reported on classification of raw electrocardiograms (ECGs) using convolutional neural networks (CNNs).We investigated an application-specific CNN a custom ensemble features designed based characteristics the ECG during atrial fibrillation (AF) to reduce inappropriate AF detections in implantable cardiac monitors (ICMs).An was developed and combined form input signal for CNN. The were morphological AF, incoherence RR intervals, fact that begets more AF. A model RESNET18...
Background Guideline recommendations for oral anticoagulation (OAC) in patients with atrial fibrillation (AF) are based on CHA 2 DS ‐VASc score alone. Patients cardiac implantable electronic devices provide an opportunity to assess how the interaction between AF duration and influences OAC prescription rates. Methods Results Data from Optum de‐identified Electronic Health Record data set were linked Medtronic CareLink database of devices. An index date was assigned as later 6 months after...
Abstract Aims Implantable loop recorders (ILRs) provide continuous single-lead ambulatory electrocardiogram (aECG) monitoring. Whether these aECGs could be used to identify worsening heart failure (HF) is unknown. Methods and results We linked ILR aECG from Medtronic device database the left ventricular ejection fraction (LVEF) measurements in Optum® de-identified electronic health record dataset. trained an artificial intelligence (AI) algorithm [aECG-convolutional neural network (CNN)] on...
Continuous monitoring using cardiovascular implantable electronic devices (CIEDs) allows for accurate assessment of atrial fibrillation (AF) duration and burden. Recent trials show that oral anticoagulant (OAC) reduces stroke risk in device-detected AF, though the AF threshold benefits most from OAC has not been well established.