Kenneth B. Beckman
A5059093059- Asthma and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Mitochondrial Function and Pathology
- SARS-CoV-2 detection and testing
- Genomics and Phylogenetic Studies
- Genetic Associations and Epidemiology
- Biosensors and Analytical Detection
- Telomeres, Telomerase, and Senescence
- CRISPR and Genetic Engineering
- Cancer, Lipids, and Metabolism
- DNA Repair Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Iron Metabolism and Disorders
- Gut microbiota and health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Folate and B Vitamins Research
- Genomics and Chromatin Dynamics
- Health, Environment, Cognitive Aging
- Genomics and Rare Diseases
- Long-Term Effects of COVID-19
University of Minnesota
2015-2024
The Ohio State University
2023
Comprehensive Eye Care
2023
Diversitech (United States)
2021
National Jewish Health
2019
University of Colorado Denver
2019
Pittsburgh Supercomputing Center
2015
University of Minnesota Medical Center
2015
Cambridge University Press
2013
New York University Press
2013
Oxidative DNA damage is important in aging and the degenerative diseases of such as cancer. Estimates commonly rely on measurements 8-oxo-2′-deoxyguanosine (oxo 8 dG), an adduct that occurs also excreted urine after repair. Here we examine difficulties inherent analysis oxo dG, identify sources artifacts, provide solutions to some common methodological problems. A frequent criticism has been phenol extraction artificially increases measured level dG. We found contributes a real but minor...
Understanding the consequences of regulatory variation in human genome remains a major challenge, with important implications for understanding gene regulation and interpreting many disease-risk variants that fall outside protein-coding regions. Here, we provide direct window into genetic by sequencing RNA from 922 genotyped individuals. We present comprehensive description distribution variation--by specific expression phenotypes altered, properties affected genes, genomic characteristics...
A common refrain in recent microbiome-related academic meetings is that the field needs to move away from broad taxonomic surveys using 16S sequencing and toward more powerful longitudinal studies shotgun sequencing. However, performing deep large remains prohibitively expensive for all but most well-funded research labs consortia, which leads many researchers choose studies, followed by on a subset of targeted samples. Here, we show shallow- or moderate-depth may be used obtain...
Environmental effects on phenotype can be mediated by epigenetic modifications. The state of the murine A vy allele is highly variable, and determines phenotypic that vary in a mosaic spectrum shifted utero exposure to methyl donor supplementation. We have asked if supplementation affects germ-line allele. find somatic affected only when paternally contributed. Exposure during midgestation shifts phenotypes not mice exposed as fetuses, but their offspring. This finding indicates donors...
Human aging is associated with skeletal muscle atrophy and functional impairment (sarcopenia). Multiple lines of evidence suggest that mitochondrial dysfunction a major contributor to sarcopenia. We evaluated whether healthy was transcriptional profile reflecting resistance exercise could reverse this signature approximating younger physiological age. Skeletal biopsies from older (N = 25) 26) adult men women were compared using gene expression profiling, subset these related measurements...
A study of genome-wide gene expression in major depressive disorder (MDD) was undertaken a large population-based sample to determine whether altered levels genes and pathways could provide insights into biological mechanisms that are relevant this disorder. Gene studies have the potential detect changes may be because differences common or rare genomic sequence variation, environmental factors their interaction. We recruited European ancestry 463 individuals with recurrent MDD 459 controls,...
The population of Argentina is the result intermixing between several groups, including Indigenous American, European and African populations. Despite commonly held idea that mostly origin, multiple studies have shown this process admixture had an impact in entire Argentine population. In present study we characterized distribution ancestry among individuals from different regions evaluated level discrepancy self-reported grandparental origin genetic estimates. A set 99 autosomal informative...
Abstract The genetic contributions to breast cancer development among Latinas are not well understood. Here we carry out a genome-wide association study of in and identify significant risk variant, located 5′ the Estrogen Receptor 1 gene ( ESR1 ; 6q25 region). minor allele for this variant is strongly protective (rs140068132: odds ratio (OR) 0.60, 95% confidence interval (CI) 0.53–0.67, P =9 × 10 −18 ), originates from Indigenous Americans uncorrelated with previously reported variants at...
Precision or personalized medicine through clinical genome and exome sequencing has been described by some as a revolution that could transform healthcare delivery, yet it is currently used in only small fraction of patients, principally for the diagnosis suspected Mendelian conditions targeting cancer treatments. Given burden illness our society, interest to ask how can be constructively integrated more broadly into routine practice betterment public health. In November 2014, 46 experts...
Abstract Background The global COVID-19 pandemic has led to an urgent need for scalable methods clinical diagnostics and viral tracking. Next generation sequencing technologies have enabled large-scale genomic surveillance of SARS-CoV-2 as thousands isolates are being sequenced around the world deposited in public data repositories. A number using both short- long-read currently applied sequencing, including amplicon approaches, metagenomic methods, sequence capture or enrichment methods....
Fibrotic idiopathic interstitial pneumonias (fIIP) are a group of fatal lung diseases with largely unknown etiology and without definitive treatment other than transplant to prolong life. There is strong evidence for the importance both rare common genetic risk alleles in familial sporadic disease. We have previously used genome-wide single nucleotide polymorphism data identify 10 loci fIIP. Here we extend that work imputed genotypes conduct new RNA sequencing studies tissue characterize...
The SARS-CoV-2 virus enters cells via Angiotensin-converting enzyme 2 (ACE2), disrupting the renin-angiotensin-aldosterone axis, potentially contributing to lung injury. Treatment with angiotensin receptor blockers (ARBs), such as losartan, may mitigate these effects, though induction of ACE2 could increase viral entry, replication, and worsen disease.
SARS-CoV-2 viral entry may disrupt angiotensin II (AII) homeostasis, contributing to COVID-19 induced lung injury. AII type 1 receptor blockade mitigates injury in preclinical models, although data humans with remain mixed.To test the efficacy of losartan reduce hospitalized patients COVID-19.This blinded, placebo-controlled randomized clinical trial was conducted 13 hospitals United States from April 2020 February 2021. Hospitalized and a respiratory sequential organ failure assessment...
Abstract Background Metformin has antiviral activity against RNA viruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The mechanism appears to be suppression of protein translation via targeting the host mechanistic target rapamycin pathway. In COVID-OUT randomized trial for outpatient disease 2019 (COVID-19), metformin reduced odds hospitalizations/death through 28 days by 58%, emergency department visits/hospitalizations/death 14 42%, and long COVID 10 months...