Hrishikesh Belani
A5052058188- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- Health Systems, Economic Evaluations, Quality of Life
- Vaccine Coverage and Hesitancy
- COVID-19 and Mental Health
- Opioid Use Disorder Treatment
- Sex work and related issues
- Pharmaceutical studies and practices
- Tryptophan and brain disorders
- Vitamin C and Antioxidants Research
- Substance Abuse Treatment and Outcomes
- Genital Health and Disease
- Electroconvulsive Therapy Studies
- Cervical Cancer and HPV Research
- Pharmacological Effects and Toxicity Studies
- Health Policy Implementation Science
- PARP inhibition in cancer therapy
- Respiratory Support and Mechanisms
- Ethics in Clinical Research
- Homelessness and Social Issues
- Pharmaceutical Practices and Patient Outcomes
- Smoking Behavior and Cessation
Olive View-UCLA Medical Center
2022-2024
University of California, Los Angeles
2022-2024
University of Minnesota
2024
Institute of Accelerating Systems and Applications
2024
Medizinisches Laserzentrum Lübeck (Germany)
2023
Los Angeles County Department of Public Health
2023
Centers for Disease Control and Prevention
2008-2014
St. John's National Academy of Health Sciences
2014
Harm Reduction Services
2008
Early treatment to prevent severe coronavirus disease 2019 (Covid-19) is an important component of the comprehensive response acute respiratory syndrome 2 (SARS-CoV-2) pandemic.
Abstract Background Metformin has antiviral activity against RNA viruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The mechanism appears to be suppression of protein translation via targeting the host mechanistic target rapamycin pathway. In COVID-OUT randomized trial for outpatient disease 2019 (COVID-19), metformin reduced odds hospitalizations/death through 28 days by 58%, emergency department visits/hospitalizations/death 14 42%, and long COVID 10 months...
Long Covid is an emerging chronic illness potentially affecting millions, sometimes preventing the ability to work or participate in normal daily activities. COVID-OUT was investigator-initiated, multi-site, phase 3, randomized, quadruple-blinded placebo-controlled clinical trial (NCT04510194). The design simultaneously assessed three oral medications (metformin, ivermectin, fluvoxamine) using two by parallel treatment factorial assignment efficiently share placebo controls and outcomes for...
Data conflict on whether vaccination decreases severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load. The objective of this analysis was to compare baseline load and symptoms between vaccinated unvaccinated adults enrolled in a randomized trial outpatient disease 2019 (COVID-19) treatment.
Current antiviral treatment options for SARS-CoV-2 infections are not available globally, cannot be used with many medications, and limited to virus-specific targets.
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Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination has decreasing protection from acquiring any infection with emergence of new variants; however, continues to protect against progression severe disease 2019 (COVID-19). The impact status on symptoms over time is less clear. Methods Within a randomized trial early outpatient COVID-19 therapy testing metformin, ivermectin, and/or fluvoxamine, participants recorded daily for 14 days. Participants were...
Abstract Background Human papillomavirus ( HPV ) is the most common sexually transmitted infection in world. It can lead to anogenital, cervical, and head neck cancer, with higher risk of malignant disease patients human immunodeficiency virus HIV )/acquired syndrome AIDS patients. In India, 73,000 130,000 women diagnosed cervical cancer die annually. Gardasil ® , a vaccine available against types 6, 11, 16, 18, approved for use India but not men. A backlash post‐licensure trials has created...
HIV risk perceptions and behaviors of 236 commercial sex workers from three major Mozambican urban centers were studied using the International Rapid Assessment, Response Evaluation (I-RARE) methodology. All offered testing and, in Maputo, syphilis was as well. Sixty-three opted for testing, with 30 (48%) positive HIV. In all receiving tests also had 6 (20%) found to be positive. Results include interview excerpts qualitative results I-RARE methodology AnSWR-assisted analyses interviews...
Shared needle and syringe use among injection drug users continues to be a major mode of transmission HIV. Needle exchange (NSE) may viable strategy reduce the virus; yet difficulty in measuring actual efficacy NSE has limited attempts evaluate cost-effectiveness intervention. Using data specific Lower East Side Harm Reduction Center New York City, we assessed over range conservative estimates efficacy, obtained from both longitudinal small-area studies. A decision-analysis model was created...
Although public efforts to reduce tobacco use have been successful, millions of US adults currently smoke tobacco. Reducing the health burden disorder (TUD) and eliminating disparities experienced by underresourced communities requires increased accessibility services. The goal this study was assess whether prescriptions for evidence-based medications treatment showed steeper growth rates among community clinics providing specialty TUD services as compared with usual.Clinic-wide data on...
Abstract This study describes decentralized recruitment and enrollment for a COVID-19 treatment trial, while comparing 5 primary methods: search engine ads, paid advertising within national testing company, regional electronic health record messages, word of mouth. These are compared across patient demographics, efficiency, cost. Clinical Trials Registration NCT04510194.
OBJECTIVES/GOALS: Chronic or new symptoms after infection with severe-acute-respiratory-coronavirus-2 (SARS-CoV-2) has been termed post-acute sequelae of Covid-19 (PASC) Long Covid. Our objective is to present results from COVID-OUT, a phase 3 double-blind, randomized controlled trial early outpatient treatment repurposed medications. METHODS/STUDY POPULATION: COVID-OUT enrolled adults age 30 85 overweight obesity who had proof SARS-CoV-2 and fewer than 7 days symptoms. In this 2 by...
Abstract The COVID-19 pandemic accelerated the development of decentralized clinical trials (DCT). DCT’s are an important and pragmatic method for assessing health outcomes yet comprise only a minority trials, few published methodologies exist. In this report, we detail operational components COVID-OUT, decentralized, multicenter, quadruple-blinded, randomized trial that rapidly delivered study drugs nation-wide. examined three medications (metformin, ivermectin, fluvoxamine) as outpatient...
Harm reduction is an accumulation of strategies aimed at preventing adverse health outcomes associated with illicit substance use. Several harm programs and services exist within Los Angeles County (LAC), however their success relies in part on the application principles by local primary care providers serving patients use disorders. This study aims to assess readiness patient-centered medical homes San Fernando Valley provide effective who injection drugs identify barriers doing so. An...