A5101631486- Substance Abuse Treatment and Outcomes
- Opioid Use Disorder Treatment
- Health Policy Implementation Science
- Mental Health Treatment and Access
- Melanoma and MAPK Pathways
- Pharmaceutical Practices and Patient Outcomes
- Mental Health and Patient Involvement
- Cancer Mechanisms and Therapy
- Smoking Behavior and Cessation
- Wind Energy Research and Development
- Oral and gingival health research
- Primary Care and Health Outcomes
- Renal Transplantation Outcomes and Treatments
- Wind and Air Flow Studies
- PI3K/AKT/mTOR signaling in cancer
- Meteorological Phenomena and Simulations
- Integrated Energy Systems Optimization
- Behavioral Health and Interventions
- Big Data and Business Intelligence
- Global Energy Security and Policy
- Human Resource and Talent Management
- Colorectal Cancer Treatments and Studies
- Business and Economic Development
- Management and Organizational Practices
- Renewable energy and sustainable power systems
University of California, Los Angeles
2016-2024
Los Angeles County Department of Public Health
2022-2024
Array BioPharma (United States)
2004-2023
Malden Public Schools
2023
Medizinisches Laserzentrum Lübeck (Germany)
2023
RAND Corporation
2023
University of New Mexico
2023
University of Washington
2023
Los Angeles County Department of Health Services
2020-2022
LAC+USC Medical Center
2022
Abstract Purpose: The Ras-Raf-mitogen-activated protein kinase (MEK) pathway is overactive in many human cancers and thus a target for novel therapeutics. We have developed highly potent selective inhibitor of MEK1/2. purpose these studies has been to show the biological efficacy ARRY-142886 (AZD6244) enzymatic, cellular, animal models. Experimental Design: ability inhibit purified MEK1 as well other kinases was evaluated. Its effects on extracellular signal-regulated (ERK) phosphorylation...
With the onset of COVID-19 crisis, many federal agencies relaxed policies regulating opioid use disorder treatment. The impact these changes has been minimally documented. abrupt nature shifts provides a naturalistic opportunity to examine adaptations for treatment in primary care.To change medical and behavioral health appointment frequency, visit type, management patients with response COVID-19.A 14-item survey queried care practices that were enrolled medications statewide expansion...
Abstract Activation of the Ras/Raf/MEK/MAP kinase pathway is implicated in uncontrolled cell proliferation and tumor growth. Inappropriate activation RAS can occur through several distinct mechanisms, including activating mutations Ras B-raf, or activated growth factor-signaling, cytokines stress responses. Mutated, oncogenic forms are found 50% colon, 90% pancreatic, 30% lung cancers. Also, B-Raf have been identified more than 60% malignant melanomas from 40-70% papillary thyroid MEK, a...
To combat the opioid epidemic in USA, unprecedented federal funding has been directed to states and territories expand access prevention, overdose rescue, medications for use disorder (MOUD). Similar other states, California rapidly allocated these funds increase reach adoption of MOUD safety-net, primary care settings such as Federally Qualified Health Centers. Typical current real-world implementation endeavors, a package four strategies was offered all clinics. The present study examines...
Opioid use disorders (OUDs) have devastating effects on individuals, families, and communities. While medication treatments for OUD save lives are increasingly utilized, rates of treatment dropout very high. In addition, most existing may often neglect the impact untreated relationships ignore potential role support persons (SPs) could encouraging long-term recovery, which can also patient retention.The current study adapts Community Reinforcement Family Training (CRAFT) with SPs (family...
The authors examined the prevalence of co-occurring opioid use disorder and willingness to engage in treatment among clients eight Los Angeles County Department Mental Health outpatient clinics.Adults presenting for an appointment over a 2-week period were invited complete voluntary, anonymous health survey. Clients who indicated past year offered longer survey assessing probable disorder. Willingness take medication receive also was assessed.In total, 3,090 completed screening. Among these,...
Abstract Background Opioid use disorders (OUD), co-occurring with either depression and/or PTSD, are prevalent, burdensome, and often receive little or low-quality care. Collaborative care is a service delivery intervention that uses team-based model to improve treatment access, quality, outcomes in primary patients, but has not been evaluated for OUD mental health disorders. To address this quality gap, we adapted collaborative Methods Our called Collaboration Leading Addiction Treatment...
Los Angeles County Department of Health Services provides medical care to a diverse group patients residing in underresourced communities. To improve patients' access addiction medications during the COVID-19 pandemic, established low-barrier telephone service for DHS providers March 2020, staffed by DATA-2000-waivered experienced with prescribing medications. This study describes patient population and prescribed through this its initial 12 months.We performed retrospective evaluation...
Although public efforts to reduce tobacco use have been successful, millions of US adults currently smoke tobacco. Reducing the health burden disorder (TUD) and eliminating disparities experienced by underresourced communities requires increased accessibility services. The goal this study was assess whether prescriptions for evidence-based medications treatment showed steeper growth rates among community clinics providing specialty TUD services as compared with usual.Clinic-wide data on...
The long-term wind resource at a potential windfarm site may be estimated by correlating short-term on-site measurements with data from regional meteorological station. Three correlation methods developed Airtricity are described, and their accuracy assessed.
In the context of increasing rates methamphetamine (meth) overdose in Los Angeles County, California, USA, 2021 County Department Public Health relaunched Meth Free LA a public education campaign built on Rescue Agency's Decision BlocksTM Strategic Framework. To assess reach and reception, we examined media data an online cross-sectional post-campaign survey with convenience sample 750 county residents ages 18-54 who had used meth, were at-risk, or personal relationships people at-risk. We...
ABSTRACT: In a prospective randomized clinical trial to compare treatment with cyclosporin A conventional azathioprine, prednisone and antithymocyte immunoglobulin in cadaveric renal transplantation, 34 patients were entered into both groups examined regularly for seven 43 months. Renal graft survival at one year was 72% among receiving therapy 75% those therapy. Rejection frequent complication of treatments; irreversible rejection occurred six 10 The nephrotoxicity its main side-effect....
The future European power system will have a hierarchical structure created by layers of control from Supergrid via regional high-voltage transmission through to medium and low-voltage distribution. Each level generation sources such as large-scale offshore wind, wave, solar thermal, nuclear directly connected this high levels embedded generation, the medium-voltage distribution system. It is expected that fuel portfolio be dominated wind in Northern Europe PV Southern Europe. strategies...