A5057042375- Neuroscience of respiration and sleep
- Spinal Cord Injury Research
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Infant Health and Development
- Neuroendocrine regulation and behavior
- Environmental Toxicology and Ecotoxicology
- Renal Transplantation Outcomes and Treatments
- Nerve Injury and Rehabilitation
- Zebrafish Biomedical Research Applications
- Respiratory Support and Mechanisms
- Toxic Organic Pollutants Impact
- Congenital Diaphragmatic Hernia Studies
- Fish Ecology and Management Studies
- Health, Medicine and Society
- Retirement, Disability, and Employment
- Neonatal Respiratory Health Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Agriculture and Rural Development Research
- Pain Management and Treatment
- Cardiac pacing and defibrillation studies
- Aquaculture Nutrition and Growth
- Anesthesia and Neurotoxicity Research
- Polyomavirus and related diseases
- Organ Transplantation Techniques and Outcomes
The Metabolomics Innovation Centre
2023-2025
Genomics (United Kingdom)
2024-2025
University of Alberta
2021-2023
University College of Osteopathy
2019-2023
University of Calgary
2016-2020
Aix-Marseille Université
2009-2018
Laboratoire de Neurosciences Cognitives
2018
University of Ottawa
2018
Advocates for Human Potential (United States)
2016
Lakehead University
2013-2015
Although axon regeneration is limited in the central nervous system, partial lesions of spinal cord induce neuroplasticity processes that can lead to spontaneous functional improvement. To determine whether such compensatory mechanisms occur respiratory we analyzed incidence injury cervical on diaphragm activity adult rats. We show a section lateral area C2 induces complete phrenic nerve inactivation and ipsilateral hemidiaphragm paralysis, whereas medial or dorsolateral sections had only...
Spinal cord injury (SCI) triggers a complex cellular response at the site, leading to formation of dense scar tissue. Despite this local tissue remodeling, consequences SCI level in distant rostral sites (i.e., brain), remain unknown. In study, we asked whether cervical could alter cell dynamics neurogenic areas adult rat forebrain. To aim, quantified BrdU incorporation and determined phenotypes newly generated cells (neurons, astrocytes, or microglia) during subchronic chronic phases...
Background. Initial analysis of liver transplant biopsies in the INTERLIVER study (ClinicalTrials.gov; unique identifier NCT03193151) using rejection-associated transcripts failed to find an antibody-mediated rejection state (ie, rich natural killer [NK] cells and with interferon-gamma effects). We recently developed optimization strategy lung transplants that isolated NK cell–enriched rejection-like (NKRL) was molecularly distinct from T cell–mediated (TCMR). Here we apply same a biopsy...
<title>Abstract</title> T-cell mediated rejection (TCMR) remains a significant challenge after kidney transplantation and is associated with reduced allograft outcome. Previous research highlighted the critical role of TCMR-induced renal epithelial injury. Yet, detailed cellular origin these injury responses clinical implications remain poorly understood. To induce acute TCMR, we used mouse models allogeneic (C57BL/6 to BALB/c C57BL/6) syngeneic controls C57BL/6 BALB/c). Molecular changes...
Among all biopsies in the Trifecta-Kidney Study ( ClinicalTrials.gov NCT04239703), elevated plasma donor-derived cell-free DNA (dd-cfDNA) correlated most strongly with molecular antibody-mediated rejection (AMR) but was also other states: T cell-mediated (TCMR), acute kidney injury (AKI), and some apparently normal biopsies. The present study aimed to define correlates of dd-cfDNA within specific states.
Mixtures of metals and polycyclic aromatic hydrocarbons (PAHs) are commonly found in aquatic environments. Emerging reports have identified that more-than-additive mortality is common metal–PAH mixtures. Individual aspects PAH toxicity suggest they may alter the accumulation enhance metal-derived reactive oxygen species (ROS). Redox-active (e.g., Cu Ni) also capable enhancing redox cycling PAHs. Accordingly, we explored mutual effects redox-active PAHs on oxidative stress, potential for to...
Abstract After disruption of the descending respiratory pathways induced by unilateral cervical spinal cord injury (SCI) in rats, inactivated ipsilateral (ipsi) phrenic nerve (PN) discharge may partially recover following some specific experimental procedures [such as contralateral (contra) phrenicotomy (Phx)]. This reactivation involves normally silent contra decussating at level nucleus, but mechanisms this crossed activation are still poorly understood. The present study investigates...
Abstract High cervical spinal cord injury (SCI) interrupts bulbospinal respiratory pathways innervating phrenic motoneurons, and induces an inactivation of nerves (PN) diaphragm. We have previously shown that the ipsilateral (ipsi) PN was inactivated following a lateral C2 SCI, but spontaneously partially reactivated 7 days post ‐ SCI. This reactivation depended on contralateral (contra) descending pathways, located laterally, cross midline. analysed here whether long‐term post‐lesional...