A5072251378- Neuroscience of respiration and sleep
- Infant Health and Development
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Respiratory and Cough-Related Research
- Dysphagia Assessment and Management
- Voice and Speech Disorders
- Tracheal and airway disorders
- Neuropeptides and Animal Physiology
- Child Nutrition and Feeding Issues
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Neonatal and fetal brain pathology
- Cannabis and Cannabinoid Research
- Vestibular and auditory disorders
- Neurotransmitter Receptor Influence on Behavior
- Alzheimer's disease research and treatments
- Gastroesophageal reflux and treatments
- Heart Rate Variability and Autonomic Control
- Neuroscience and Neuropharmacology Research
- Obstructive Sleep Apnea Research
- Language Development and Disorders
- Dietary Effects on Health
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Anesthesia and Neurotoxicity Research
Institut de Neurobiologie de la Méditerranée
2021-2023
Inserm
2000-2023
Aix-Marseille Université
2009-2023
Institut de Neurosciences des Systèmes
2018-2021
University of South Florida
2015-2019
Centre de Recherche en Neurobiologie - Neurophysiologie de Marseille
2008-2018
Centre National de la Recherche Scientifique
2005-2016
Centre de Gestion Scientifique
2011
École Pratique des Hautes Études
2000-2003
University of Tampa
2001
Task2 K(+) channel expression in the central nervous system is surprisingly restricted to a few brainstem nuclei, including retrotrapezoid (RTN) region. All Task2-positive RTN neurons were lost mice bearing Phox2b mutation that causes human congenital hypoventilation syndrome. In plethysmography, Task2(-/-) showed disturbed chemosensory function with hypersensitivity low CO(2) concentrations, leading hyperventilation. probably needed stabilize membrane potential of chemoreceptive cells....
Phox2b-expressing glutamatergic neurons of the retrotrapezoid nucleus (RTN) display properties expected central respiratory chemoreceptors; they are directly activated by CO 2 /H + via an unidentified pH-sensitive background K channel and, in turn, facilitate brainstem networks that control breathing. Here, we used a knock-out mouse model to examine whether TASK-2 (K2P5), alkaline-activated channel, contributes RTN neuronal pH sensitivity. We made patch-clamp recordings slices from were...
JMJD3 (KDM6B) antagonizes Polycomb silencing by demethylating lysine 27 on histone H3. The interplay of methyltransferases and demethylases at this residue is thought to underlie critical cell fate transitions, the dynamics H3K27me3 during neurogenesis posited for a role in acquisition neural fate. Despite evidence its involvement early commitment, however, emergence maturation mammalian CNS remains unknown. Here, we inactivated Jmjd3 mouse found that loss causes perinatal lethality with...
This study addressed the hypothesis that ventrolateral medullary respiratory neurones participate in control of laryngeal motoneurones during both eupnoea and coughing. Data were obtained from 28 mid‐collicular decerebrated, artificially ventilated cats. Cough‐like motor patterns (fictive cough) phrenic, lumbar recurrent nerves elicited by mechanical stimulation intrathoracic trachea. Microelectrode arrays used to monitor simultaneously several ventral group, including Bötzinger...
Tauopathy comprises hyperphosphorylation of the microtubule-associated protein tau, causing intracellular aggregation and accumulation as neurofibrillary tangles neuropil treads. Some primary tauopathies are linked to mutations in MAPT gene coding for but most sporadic with unknown causes. Also, Alzheimer's disease, frequent secondary tauopathy, neither cause nor pathological mechanisms repercussions understood. Transgenic mice expressing mutant Tau-P301L suffer cognitive motor defects die...
We used the expression of immediate-early gene c-fos, a marker neuronal activation, to localize brainstem populations functionally related fictive cough (FC). In decerebrate, paralyzed, and ventilated cats, level Fos-like immunoreactivity (FLI) was examined in five groups animals: (1) controls, sham-operated unstimulated animals; (2) coughing including both animals which FC elicited by unilateral electrical stimulation superior laryngeal nerve (SLN) (3) those bilateral SLN stimulation; (4)...
Perinatal brain injury including white matter damage (WMD) is highly related to sensory, motor or cognitive impairments in humans born prematurely. Our aim was examine the neuroanatomical, functional and behavioral changes adult rats that experienced prenatal ischemia (PI), thereby inducing WMD. PI induced by unilateral uterine artery ligation at E17 pregnant rats. We assessed performances gait, abilities topographical organization of maps, neuronal glial density primary somatosensory...
Background Tauopathies, including Alzheimer's Disease, are the most frequent neurodegenerative diseases in elderly people and cause various cognitive, behavioural motor defects, but also progressive language disorders. For communication social interactions, mice produce ultrasonic vocalization (USV) via expiratory airflow through larynx. We examined USV of Tau.P301L mice, a mouse model for tauopathy expressing human mutant tau protein developing upper airway defects. Methodology/Principal...
Abstract In the cochlea, K + is essential for mechano-electrical transduction. Here, we explore cochlear structure and function in mice lacking channels of two-pore domain family. A profound deafness associated with a decrease endocochlear potential found adult Kcnk5 −/− mice. Hearing occurs around postnatal day 19 (P19), completely disappears 2 days later. At P19, have normal endolymphatic [K ] but partly lowered potential. Using Lac-Z as gene reporter, KCNK5 mainly outer sulcus Claudius’,...
Swallow-breathing coordination safeguards the lower airways from tracheal aspiration of bolus material as it moves through pharynx into esophagus. Impaired movements shared muscles or structures aerodigestive tract, disruptions in interaction brainstem swallow and respiratory central pattern generators (CPGs) result dysphagia. To maximize airway protection these CPGs integrate rhythm generation signals vagal afferent feedback to synchronize with breathing. Despite extensive study, roles...
This study examined the possibility that a tonic activity in endogenous opioid systems (EO systems) exists animals under normal conditions. In first set of experiments, concurrent changes behavioral responses and numbers c-Fos-like immunoreactive (Fos-LI) neurons 58 structures brain lumbosacral spinal cord were analyzed rats after systemic administration antagonist naloxone (NAL; 2 mg/kg). Possible roles EO inferred from Fos-LI between received either NAL or same volume saline. Free-floating...
Abstract This study examined the effects of anesthesia on hypoglossal nerve and diaphragm activities c‐Fos expression in brainstem premotor neurons (pmXII). Experiments were performed 71 rats by using halothane inhalation, pentobarbital sodium, or mixtures α‐chloralose urethane ketamine xylazine. First, various cardiorespiratory parameters measured (n = 31) during both awake anesthetized conditions. The volatile anesthetic halothane, but not other anesthetics, was always associated with a...