A5039849812- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Birth, Development, and Health
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Infant Development and Preterm Care
- Cannabis and Cannabinoid Research
- Adipose Tissue and Metabolism
- High Altitude and Hypoxia
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Ion channel regulation and function
- Metabolism and Genetic Disorders
- Wnt/β-catenin signaling in development and cancer
- Cerebral Palsy and Movement Disorders
- Metabolism, Diabetes, and Cancer
- Epigenetics and DNA Methylation
- Infant Health and Development
- Medical Research and Treatments
- Dysphagia Assessment and Management
- Spinal Cord Injury Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuropeptides and Animal Physiology
- Children's Physical and Motor Development
Institut de Neurosciences de la Timone
2014-2022
Centre National de la Recherche Scientifique
2000-2020
Aix-Marseille Université
2014-2020
Centre de Recherche en Neurobiologie - Neurophysiologie de Marseille
2009-2011
Université Claude Bernard Lyon 1
2000-2008
Centre de recherche Translationnelle en Médecine moléculaire
2007
Karolinska Institutet
1997-2006
Laboratoire de Biologie et Modélisation de la Cellule
2000-2003
Laboratoire de Physique de l'ENS de Lyon
2001
Task2 K(+) channel expression in the central nervous system is surprisingly restricted to a few brainstem nuclei, including retrotrapezoid (RTN) region. All Task2-positive RTN neurons were lost mice bearing Phox2b mutation that causes human congenital hypoventilation syndrome. In plethysmography, Task2(-/-) showed disturbed chemosensory function with hypersensitivity low CO(2) concentrations, leading hyperventilation. probably needed stabilize membrane potential of chemoreceptive cells....
1. To define the effects of prenatal hypoxia on postnatal development chemoafferent pathway, ventilation and metabolism, pregnant rats were exposed to normobaric (10 % oxygen) from embryonic day 5 20. Offspring studied at 1, 3 9 weeks age in three separate protocols. 2. Prenatal decreased dopamine content carotid bodies all ages, utilisation rate noradrenaline caudal part A2 (A2c), A1 A5 noradrenergic brainstem cell groups after birth. At age, level was still reduced but enhanced A1. 3. Rats...
The central pattern generator (CPG) for locomotion is a set of pacemaker neurons endowed with inherent bursting driven by the persistent sodium current ( I NaP ). How they proceed to regulate locomotor rhythm remained unknown. Here, in neonatal rodents, we identified potassium critical regulating pacemakers and speed. This recapitulates features M-current M ): subthreshold noninactivating outward blocked 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone dihydrochloride (XE991) enhanced N...
The first step of this study was to determine the early time course and pattern hypoxic ventilatory response (HVR) recovery following irreversible bilateral carotid sinus nerve transection (CSNT). second find out if HVR associated with changes in neurochemical activity medullary catecholaminergic cell groups involved O 2 chemoreflex pathway. breathing acute hypoxia (10% ) measured awake rats 2, 6, 10, 45 90 days after CSNT. In a control group sham‐operated rats, principally due increased...
Motor control and body representation in the central nervous system (CNS) as well musculoskeletal architecture physiology are shaped during development by sensorimotor experience feedback, but emergence of locomotor disorders maturation their persistence over time remain a matter debate absence brain damage. By using transient immobilization hind limbs, we investigated enduring impact postnatal restriction (SMR) on gait posture treadmill, age-related changes locomotion, histopathology...
Intrauterine ischemia-hypoxia is detrimental to the developing brain and leads white matter injury (WMI), encephalopathy of prematurity (EP), often cerebral palsy (CP), but related pathophysiological mechanisms remain unclear. In prior studies, we used mild intrauterine hypoperfusion (MIUH) in rats successfully reproduce diversity clinical signs EP, some CP symptoms. Briefly, MIUH led inflammatory processes, diffuse gray WMI, minor locomotor deficits, musculoskeletal pathologies,...
Summary. The aim of the present study was to investigate effect metformin on insulin sensitivity, adipose tissue mass and sympathetic nervous system (SNS) activity in fructose fed rats. Male Sprague-Dawley rats were for six weeks either a standard diet (C group) or high-fructose (F group, 10% drinking water). In each half animals received water last 4 (500 mg/kg x day, C+M F+M). Hyperinsulinemic-euglycemic clamps (6 mU insulin/kg.min) performed awake unrestrained test resistance. Six-week...
Abstract The chemoreflex pathway undergoes postnatal maturation, and the perinatal environment plays a critical role in shaping respiratory control system. We investigated of prenatal hypoxia on maturation neural circuits regulating ventilation rat. Effects (10% O 2 ) from 5th to 20th day gestation were studied male offspring at birth days 3, 7, 21 68. Maturation system was assessed by vivo tyrosine hydroxylase (TH) activity measurement peripheral chemoreceptors (carotid bodies, petrosal...
Abstract Cannabis is one of the most commonly used recreational drugs at ages highly correlated with potential pregnancy. Endocannabinoid signalling regulates important stages neuronal development. When cannabinoid receptors, which are widely distributed through nervous system, activated by exogenous cannabinoids, breathing in adult rats depressed. Here, we show that, newborn mice, endocannabinoids, activation receptor type 1 ( CB R ), participate modulation respiration and its control....
Prenatal hypoxia is a recognised risk factor for neurodevelopmental disorders associated with both membrane proteins involved in neuron homeostasis, e.g., chloride (Cl-) cotransporters, and alterations brain neurotransmitter systems, catecholamines, dopamine, GABA. Our study aimed to determine whether prenatal alters central respiratory drive by disrupting the development of Cl- cotransporters KCC2 NKCC1. homeostasis seems critical strength efficiency inhibition mediated GABAA glycine...
Impaired transplacental supply of oxygen leads to intrauterine growth restriction, one the most important causes perinatal mortality and respiratory morbidity. Breathing rhythm depends on central network modulated by catecholamines. We investigated impact using prenatal hypoxia, frequency, respiratory-like rhythm, its catecholaminergic modulation after birth. At birth, frequency was increased confirmed in en bloc medullary preparations, where fourth cervical (C4) ventral root discharge...
Summary The central pattern generator (CPG) for locomotion is set of pacemaker neurons endowed with inherent bursting driven by the persistent sodium current ( I NaP ). How they proceed to regulate locomotor rhythm remained unknown. Here, in neonatal rodents, we identified a potassium current, critical regulating pacemakers and speed. This recapitulates features M-current M ); subthreshold non-inactivating outward blocked XE991 enhanced ICA73. Immunostaining mutant mice highlight an...