A5022379752- Complex Systems and Time Series Analysis
- Mathematical and Theoretical Epidemiology and Ecology Models
- Theoretical and Computational Physics
- Stochastic processes and statistical mechanics
- Transportation Planning and Optimization
- Bioinformatics and Genomic Networks
- HIV Research and Treatment
- Epigenetics and DNA Methylation
- Gene expression and cancer classification
- Traffic control and management
- Time Series Analysis and Forecasting
- Cellular Automata and Applications
- Gene Regulatory Network Analysis
- Traffic Prediction and Management Techniques
- Artificial Immune Systems Applications
- Financial Risk and Volatility Modeling
- Market Dynamics and Volatility
- Complex Network Analysis Techniques
- Random Matrices and Applications
- Crystallization and Solubility Studies
- Evolution and Genetic Dynamics
- Genomics and Chromatin Dynamics
- Immune Cell Function and Interaction
- Drug Solubulity and Delivery Systems
- Evacuation and Crowd Dynamics
Dublin City University
2013-2022
University College Dublin
2009
Trinity College Dublin
2009
Capgemini (Netherlands)
2007
Royal College of Surgeons in Ireland
2006
Guy's Hospital
1978-1982
London School of Hygiene & Tropical Medicine
1978
King's College London
1976-1978
Series data for the mean cluster size site mixtures on a d-dimensional simple hypercubical lattice are presented. Numerical evidence existence of critical dimension growth function and is examined it concluded that dc=6. Exact expansions number clusters K(p) S(p) in powers 1/ sigma where =2d-1 p<pc derived through fifth third order, respectively. The zeroth-order terms Bethe approximations.
The authors study bond percolation processes on a d-dimensional simple hypercubic lattice. Exact expansions for the mean number of clusters, K(p), and cluster size, S(p), in powers 1/ sigma , where =2d-1 p<pc, are derived through fifth fourth order, respectively. zeroth-order terms Bethe approximations. critical probability pc is found to have expansion, probably asymptotic, pc= -1(1+21/2 -2+71/2 -3+57 -4+...), while growth parameter lambda can be expanded as = B(1-2 -2-...) B approximation...
With the fast development of high-throughput sequencing technologies, a new generation genome-wide gene expression measurements is under way. This based on mRNA (RNA-seq), which complements already mature technology microarrays, and expected to overcome some latter's disadvantages. These RNA-seq data pose challenges, however, as strengths weaknesses have yet be fully identified. Ideally, Next (or Second) Generation Sequencing measures can integrated for more comprehensive investigation...
The evolution of high throughput technologies that measure gene expression levels has created a data base for inferring GRNs (a process also known as reverse engineering GRNs). However, the nature these made this very difficult. At moment, several methods discovering qualitative causal relationships between genes with accuracy from microarray exist, but large scale quantitative analysis on real biological datasets cannot be performed, to date, existing approaches are not suitable which noisy...
This paper proposes Multi-stream Minimum Acceptable Space (MMAS) Cellular Automata (CA) models to study unsignalised multi-lane (two- or three-lane) urban roundabouts. Through detailed space considerations, using and the method, heterogeneity inconsistency of driver behavior interactions in cross traffic at entrances roundabouts are simulated by incorporation four different categories (i.e., conservative, moderate, urgent radical), together with reassignment given probabilities each time...
In this paper, we investigate the price interdependence between seven international stock markets, namely Irish, UK, Portuguese, US, Brazilian, Japanese and Hong Kong, using a new testing method, based on wavelet transform to reconstruct data series, as suggested by Lee [11]. We find evidence of intra-European (Irish, UK Portuguese) market co-movements with US also weakly influencing Irish market. co-movement Brazilian markets similar intra-Asian (Japanese Kong). Finally, conclude that...
Background Inferring Gene Regulatory Networks (GRNs) from time course microarray data suffers the dimensionality problem created by short length of available series compared to large number genes in network. To overcome this, integration diverse sources is mandatory. Microarray different and platforms are publicly available, but not straightforward, due platform experimental differences. Methods We analyse here normalisation approaches for integration, context reverse engineering GRN...
Abstract Background Cancer, much like most human disease, is routinely studied by utilizing model organisms. Of these organisms, mice are often dominant. However, our assumptions of functional equivalence fail to consider the opportunity for divergence conferred ~180 Million Years (MY) independent evolution between species. For a given set disease related genes, it therefore important determine if equivalency has been retained In this study we test hypothesis that cancer associated genes...
The development of colorectal cancer (CRC)-the third most common type-has been associated with deregulations cellular mechanisms stimulated by both genetic and epigenetic events. StatEpigen is a manually curated annotated database, containing information on interdependencies between signals, specialized currently for CRC research. Although provides well-developed graphical user interface retrieval, advanced queries involving associations multiple concepts can benefit from more detailed graph...
In this paper, the branching of real lattice trees is shown to be related occurrence two different prefactor exponents. For all lattices where trivalent are embeddable, exponent estimated as being animal-like in nature. addition, estimates for growth parameter given a number 2- and 3-dimensional lattices.
Characterization of the epigenetic profile humans since initial breakthrough on human genome project has strongly established key role histone modifications and DNA methylation. These dynamic elements interact to determine normal level expression or methylation status constituent genes in genome. Recently, considerable evidence been put forward demonstrate that environmental stress implicitly alters patterns causing imbalance can lead cancer initiation. This chain consequences motivated...