A5026779598- Air Quality and Health Impacts
- Health, Environment, Cognitive Aging
- Noise Effects and Management
- Climate Change and Health Impacts
- Epigenetics and DNA Methylation
- Health disparities and outcomes
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Mental Health Research Topics
- Plant Disease Resistance and Genetics
- Vaccine Coverage and Hesitancy
- Plant Pathogens and Fungal Diseases
- Childhood Cancer Survivors' Quality of Life
- Birth, Development, and Health
- Plant Pathogens and Resistance
- Heme Oxygenase-1 and Carbon Monoxide
- Energy and Environment Impacts
- COVID-19 Clinical Research Studies
- Posttraumatic Stress Disorder Research
- Impact of Light on Environment and Health
- Smoking Behavior and Cessation
- Healthcare cost, quality, practices
- Injury Epidemiology and Prevention
- Behavioral Health and Interventions
- School Health and Nursing Education
Emory University
2021-2025
Atlanta VA Medical Center
2024
University of Wisconsin–Madison
2023
University of Minnesota Medical Center
2022
Wisconsin Department of Health Services
2019-2020
Abstract Background Metformin has antiviral activity against RNA viruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The mechanism appears to be suppression of protein translation via targeting the host mechanistic target rapamycin pathway. In COVID-OUT randomized trial for outpatient disease 2019 (COVID-19), metformin reduced odds hospitalizations/death through 28 days by 58%, emergency department visits/hospitalizations/death 14 42%, and long COVID 10 months...
Fine particulate matter (PM
Abstract Background Recent research has demonstrated that domains of social determinants health (SDOH) (e.g. air pollution and context) are associated with psychosis. However, SDOHs have often been studied in isolation. This study investigated distinct exposure profiles, estimated their associations persistent distressing psychotic-like experiences (PLE), evaluated whether involvement physical activity partially explains this association. Methods Analyses included 8,145 young adolescents...
Data conflict on whether vaccination decreases severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load. The objective of this analysis was to compare baseline load and symptoms between vaccinated unvaccinated adults enrolled in a randomized trial outpatient disease 2019 (COVID-19) treatment.
It is hypothesized that air pollution and stress impact the central nervous system through neuroinflammatory pathways Despite this, association between prenatal exposure to indoor psychosocial factors on inflammatory markers in infancy has been underexplored epidemiology studies. This study investigates individual joint effects of early life inflammation (interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)). We analyzed data from South African Drakenstein Child...
Exposure to environmental toxicants and psychosocial stressors during gestation early life are particularly harmful may impact brain development. Specifically, exposure indoor air pollutants (IAP) factors (PF) these sensitive periods has been shown predict childhood psychopathology. Here, we investigated for the individual joint effects of IAP PF on psychopathology at 6.5 years. We analyzed data from Drakenstein Child Health Study (N=599). was measured second trimester pregnancy 4 months...
There is increasing evidence indicating that air pollution exposure associated with neuronal damage. Since pregnancy a critical window of vulnerability, during this period could have adverse effects on neurodevelopment. This study aims 1) to analyze associations prenatal indoor (particulate matter diameters ≤10 μm, PM
Abstract Background Exposure to indoor air pollution during pregnancy has been linked neurodevelopmental delay in toddlers. Epigenetic modification, particularly DNA methylation (DNAm), may explain this link. In study, we employed three high-dimensional mediation analysis methods (HIMA, DACT, and gHMA) followed by causal identify differentially methylated CpG sites genes that mediate the association between delay. Analyses were performed using data from 142 mother child pairs a South African...
Importance Disasters experienced by an entire community provide opportunities to understand individual differences in risk for adverse health outcomes over time. DNA methylation (DNAm) may help distinguish individuals at increased following large-scale disasters. Objective To examine the association of epigenetic age acceleration with probable posttraumatic stress disorder (PTSD) and PTSD symptom severity women. Design, Setting, Participants This prospective cohort study examined data from...
Abstract Prenatal indoor air pollution and maternal psychosocial factors have been associated with adverse psychopathology. We used environmental-exposure mixture methodology to investigate joint effects of both exposure classes on child behavior trajectories. For 360 children from the South African Drakenstein Child Health Study, we created trajectories Behavior Checklist scores (at 24, 42, 60 months) using latent-class linear mixed models. Indoor pollutants were measured during pregnancy...
Introduction: Carbon monoxide (CO) is a colorless, odorless, and nonirritating gas. The most common exposures are from gas powered appliances such as furnaces, water heaters, stoves, vehicles. To prevent poisoning, CO detectors with audible alarms were developed. This study aims to evaluate the effectiveness of in reducing poisoning Wisconsin.Methods: Records queried National Poison Data System for unintentional that occurred residences Wisconsin during 2014–2016 (N = 703). After applying...
Higher fine particulate matter (PM2.5) exposure has been found to be associated with Alzheimer's disease (AD). PM2.5 hypothesized cause inflammation and oxidative stress in the brain, contributing neuropathology. A major genetic risk factor of AD, apolipoprotein E (APOE) gene, also modify association between AD. However, little prior research exisits support these hypotheses. Therefore, this paper aims investigate traffic-related AD hallmark pathology, including effect modification by APOE...
Abstract Background Prenatal indoor air pollution and maternal psychosocial factors have been associated with adverse psychopathology. We used environmental exposure mixture methodology to investigate joint effects of both classes on child behavior trajectories. Methods For 360 children from the South African Drakenstein Child Health Study, we created trajectories Behavior Checklist scores (24, 42, 60 months) using latent class linear mixed models. Indoor pollutants were measured during...
Recent research has demonstrated that domains of social determinants health (SDOH) (e.g., air pollution and context) are associated with psychosis. However, SDOHs have often been studied in isolation.
Childhood cancer incidence is known to vary by age, sex, and race/ethnicity, but evidence limited regarding external risk factors. We aim identify harmful combinations of air pollutants other environmental social factors in association with the childhood based on 2003-2017 data from Georgia Cancer Registry. calculated standardized ratios (SIR) Central Nervous System (CNS) tumors, leukemia lymphomas gender ethnic composition each 159 counties Georgia, USA. County-level information pollution,...