A5115603995- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV Research and Treatment
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Intensive Care Unit Cognitive Disorders
- Cardiac Health and Mental Health
- Maternal Mental Health During Pregnancy and Postpartum
- S100 Proteins and Annexins
- Frailty in Older Adults
- Birth, Development, and Health
- Complex Systems and Decision Making
- Cognitive Science and Mapping
- Neuroscience and Neuropharmacology Research
- Electrolyte and hormonal disorders
- Infant Development and Preterm Care
- Macrophage Migration Inhibitory Factor
- Multi-Criteria Decision Making
- Intracerebral and Subarachnoid Hemorrhage Research
- HIV-related health complications and treatments
- Acute Kidney Injury Research
- Team Dynamics and Performance
- Traumatic Brain Injury and Neurovascular Disturbances
- Child Abuse and Trauma
- COVID-19 Impact on Reproduction
University of Cape Town
2017-2025
University Medical Center Groningen
2013-2023
University of Groningen
2013-2023
Neuroscience Institute
2019
Groote Schuur Hospital
2019
University of Antwerp
2016
University of Leeds
2002
University of Bath
2000
University of Manchester
1998
Manchester School of Architecture
1996
Extensive research has been performed to unravel the mechanistic signaling pathways mediated by tumor necrosis factor receptor 1 (TNFR1), contrast there is limited knowledge on cellular upon activation of TNFR2. Recently published data have revealed that these two receptors not only function independently, but also can influence each other via cross-talk between different initiated TNFR1 and TNFR2 stimulation. Furthermore, complexity this dependent kinetics TNFR2, which a delicate balance...
Alzheimer's disease (AD) is associated with an altered immune response, resulting in chronic increased inflammatory cytokine production a prominent role of TNF-α. TNF-α signals are mediated by two receptors: TNF receptor 1 (TNFR1) and 2 (TNFR2). Signaling through TNFR2 neuroprotection, whereas signaling TNFR1 generally proinflammatory proapoptotic. Here, we have identified TNF-α-induced agent, lipocalin (Lcn2) via gene array murine primary cortical neurons. Further investigation showed that...
Despite the recognized role of tumor necrosis factor (TNF) in inflammation and neuronal degeneration, anti-TNF therapeutics failed to treat neurodegenerative diseases. Animal disease models had revealed antithetic effects two TNF receptors (TNFR) central nervous system, whereby TNFR1 has been associated with inflammatory degeneration TNFR2 neuroprotection. We here show therapeutic potential selective inhibition activation by ATROSAB, a TNFR1-selective antagonistic antibody, EHD2-scTNFR2, an...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Accumulating experimental evidence shows important linkage between tumor necrosis factor-α (TNF) AD, but exact role TNF in AD still not completely understood. Although TNF-inhibitors are successfully used for treating several diseases, total inhibition can side effects, particularly neurological diseases. This attributed to opposing roles two receptors. receptor 1 (TNFR1) predominantly...
Objectives: Growing evidence indicates that inflammatory processes may play a role in the pathogenesis of anxiety disorders. Nevertheless, much remains to be learned about involvement inflammation, including C-reactive protein (CRP), specific This study examines relation between disorders and CRP.Methods: Associations serum CRP with were determined large population (n = 54,326 participants, mean age 47 years; 59% female), LifeLines cohort. Depressive (generalized disorder, social phobia,...
Tumor necrosis factor-α (TNF-α) is a pleiotropic, proinflammatory cytokine related to different neurodegenerative diseases, including Alzheimer's disease (AD). Although the linkage between increased TNF-α levels and AD widely recognized, TNF-α-neutralizing therapies have failed treat AD. Previous research has associated this with antithetic functions of two TNF receptors, receptor 1, inflammation apoptosis, 2 (TNFR2), neuroprotection. In our study, we investigated effects specifically...
Lipocalin 2 (Lcn2) is an acute-phase protein implicated in multiple neurodegenerative conditions. Interestingly, both neuroprotective and effects have been described for Lcn2. Increased Lcn2 levels were found human post-mortem Alzheimer (AD) brain tissue, vitro studies indicated that aggravates amyloid-β-induced toxicity. However, the role of has not studied vivo AD model. Therefore, current study, J20 mouse model AD. mice Lcn2-deficient (J20xLcn2 KO) compared at behavioral neuropathological...
Co-existing depression worsens Alzheimer's disease (AD) pathology.Neutrophil gelatinase-associated lipocalin (NGAL) is a newly identified (neuro)inflammatory mediator in the pathophysiologies of both AD and depression.This study aimed to compare NGAL levels healthy controls, without (AD-D), with co-existing (AD+D) patients.Protein its receptors, 24p3R megalin, were assessed nine brain regions from controls (n = 19), AD-D AD+D 21) patients.NGAL patients significantly increased commonly...
It is hypothesized that air pollution and stress impact the central nervous system through neuroinflammatory pathways Despite this, association between prenatal exposure to indoor psychosocial factors on inflammatory markers in infancy has been underexplored epidemiology studies. This study investigates individual joint effects of early life inflammation (interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)). We analyzed data from South African Drakenstein Child...
Abstract Children who are HIV-exposed and uninfected (HEU) at risk of neurodevelopmental delays, which may be partially due to maternal immune dysregulation during pregnancy. This study investigates associations between child profiles early neurometabolite in HEU HIV-unexposed (HU) children from a South African birth cohort. A subgroup 156 (66 HEU, 90 HU) the Drakenstein Child Health Study underwent magnetic resonance spectroscopy age 2–3 years, serum markers were measured multiple...
Children who are HIV-exposed and uninfected (HEU) at risk of neurodevelopmental delays, which may be partially due to maternal immune dysregulation during pregnancy. This study investigates associations between child profiles early neurometabolite in HEU HIV-unexposed (HU) children from a South African birth cohort. A subgroup 156 (66 HEU, 90 HU) the Drakenstein Child Health Study underwent magnetic resonance spectroscopy age 2-3 years, serum markers were measured multiple timepoints via...
Objectives To determine whether physical frailty is associated with low‐grade inflammation in older adults depression, because late‐life depression and inflammation. Design Baseline data of a cohort study. Setting Primary care specialized mental health care. Participants Individuals aged 60 according to Diagnostic Statistical Manual Mental Disorders, Fourth Edition , criteria (N = 366). Measurements The phenotype, defined as three out five (weight loss, weakness, exhaustion, slowness, low...
Abstract Objective: Findings from animal studies indicate that the early gut bacteriome is a potential mechanism linking maternal prenatal stress with health trajectories in offspring. However, clinical are scarce and associations of psychological profiles infant faecal unknown. This study aimed to investigate stressors distress bacterial South African birth cohort study. Methods: Associations between symptoms depression, distress, intimate partner violence (IPV) posttraumatic disorder...
HIV-exposed uninfected (HEU) children may have altered immune regulation and poorer neurodevelopment outcomes compared to their HIV-unexposed (HU) counterparts. However, studies investigating the association of maternal infant inflammation with in HEU are limited longitudinal data lacking. This study investigated serum inflammatory markers women living HIV vs. HIV-uninfected during pregnancy children, as well associations neurodevelopmental at two years age an African birth cohort study. A...
Antenatal exposure to maternal psychological adversity, including depression, increases the risk of impaired neurodevelopment in children. The underlying biological mechanisms remain unclear, especially early life during critical windows development and maturation. This study investigated association antenatal inflammatory markers neurodevelopmental outcomes children at 2 years age.A subgroup mothers their (n = 255) that were enrolled a South African birth cohort study, Drakenstein Child...
Numerous studies have revealed the pleiotropic functions of tumor necrosis factor alpha (TNF-α), and linked it with several neurodegenerative disorders. This review describes signaling pathways induced by TNF-α via its two receptors (TNFR1 TNFR2), their in processes as Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), ischemic stroke. It has become clear that may exert divergent actions disorders, including neuroprotective effects, which appear to depend on either TNFR1 or...