A5066243220- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Interference and Gene Delivery
- Phosphodiesterase function and regulation
- Multiple Sclerosis Research Studies
- Inflammasome and immune disorders
- Alzheimer's disease research and treatments
- Cell Adhesion Molecules Research
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Adenosine and Purinergic Signaling
- Mast cells and histamine
University of Groningen
2022-2023
University Medical Center Groningen
2022
Amsterdam UMC Location Vrije Universiteit Amsterdam
2017
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by focal inflammatory lesions and prominent demyelination. Even though currently available therapies are effective in treating initial stages disease, they unable to halt or reverse progression into progressive stage. Thus far, no repair-inducing treatments for MS patients. Hence, there an urgent need development new therapeutic strategies either targeting destructive immunological...
Tumor necrosis factor-α (TNF-α) is a pleiotropic, proinflammatory cytokine related to different neurodegenerative diseases, including Alzheimer's disease (AD). Although the linkage between increased TNF-α levels and AD widely recognized, TNF-α-neutralizing therapies have failed treat AD. Previous research has associated this with antithetic functions of two TNF receptors, receptor 1, inflammation apoptosis, 2 (TNFR2), neuroprotection. In our study, we investigated effects specifically...