A5091689516- Phosphodiesterase function and regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Mast cells and histamine
- Cholinesterase and Neurodegenerative Diseases
- Neurogenesis and neuroplasticity mechanisms
- Neuroendocrine regulation and behavior
- Adenosine and Purinergic Signaling
- MicroRNA in disease regulation
- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Neurogenetic and Muscular Disorders Research
- RNA Research and Splicing
- Machine Learning and Data Classification
- Macrophage Migration Inhibitory Factor
- Cholesterol and Lipid Metabolism
- Alzheimer's disease research and treatments
- Fatty Acid Research and Health
- Neurological Disease Mechanisms and Treatments
- Advanced Data Storage Technologies
- Medicinal Plants and Neuroprotection
- Kruppel-like factors research
- Immune cells in cancer
- Infant Health and Development
- Parallel Computing and Optimization Techniques
Maastricht University
2019-2025
European Graduate School of Neuroscience
2019-2025
Hasselt University
2019-2025
University of Würzburg
2021
Biomedical Research Institute
2021
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by focal inflammatory lesions and prominent demyelination. Even though currently available therapies are effective in treating initial stages disease, they unable to halt or reverse progression into progressive stage. Thus far, no repair-inducing treatments for MS patients. Hence, there an urgent need development new therapeutic strategies either targeting destructive immunological...
Inhibition of phosphodiesterase 4D (PDE4D) enzymes has been investigated as therapeutic strategy to treat memory problems in Alzheimer's disease (AD). Although PDE4D inhibitors are effective enhancing processes rodents and humans, severe side effects may hamper their clinical use. comprise different isoforms, which, when targeted specifically, can increase treatment efficacy safety. The function isoforms AD molecular per se remained unresolved. Here, we report the upregulation specific...
Abstract The differentiation of oligodendrocyte precursor cells (OPCs) into myelinating oligodendrocytes is the prerequisite for remyelination in demyelinated disorders such as multiple sclerosis (MS). Epigenetic mechanisms, DNA methylation, have been suggested to control intricate network transcription factors involved OPC differentiation. Yet, exact mechanism remains undisclosed. Here, we are first identify DNA-binding protein inhibitors, Id2 and Id4, targets methylation during Using...
Background: Current treatment options for Alzheimer’s disease (AD) are limited, inefficient, and often have serious side effects. Oxytocin is a neuropeptide implicated in variety of central processes, such as social reproductive behaviors. Among others, it has garnered attention various domains psychiatric research, while its role the development course neurodegenerative disorders like AD rather unknown. Objective: This study aimed to investigate exogenous oxytocin administration on memory,...
In the progressive phase of multiple sclerosis (MS), hampered differentiation capacity oligodendrocyte precursor cells (OPCs) eventually results in remyelination failure. We have previously shown that DNA methylation Id2/Id4 is highly involved OPC and remyelination. this study, we took an unbiased approach by determining genome-wide patterns within chronically demyelinated MS lesions investigated how certain epigenetic signatures relate to capacity. compared transcriptional profiles between...
We recently found that dietary supplementation with the seaweed Sargassum fusiforme, containing preferential LXRβ-agonist 24(S)-saringosterol, prevented memory decline and reduced amyloid-β (Aβ) deposition in an Alzheimer’s disease (AD) mouse model without inducing hepatic steatosis. Here, we examined effects of 24(S)-saringosterol as a food additive on cognition neuropathology AD mice. Six-month-old male APPswePS1ΔE9 mice wildtype C57BL/6J littermates received (0.5 mg/25 g body weight/day)...
Abstract Introduction In the progressive phase of multiple sclerosis (MS), hampered differentiation capacity oligodendrocyte precursor cells (OPCs) eventually results in remyelination failure. We have previously shown that DNA methylation Id2/Id4 is highly involved OPC and remyelination. this study, we took an unbiased approach by determining genome-wide patterns within chronically demyelinated MS lesions investigated how certain epigenetic signatures relate to capacity. Methods compared...
Recent advances in deep learning (dl) have led to the release of several dl software libraries such as pytorch, Caffe, and TensorFlow, order assist machine (ml) practitioners developing deploying state-of-the-art neural networks (DNN), but they are not able properly cope with limitations testing or data processing. In this paper, we present a qualitative quantitative analysis most frequent combination, distribution library dependencies across ml workflow, formulate set recommendations (i)...
Microglia activity can drive excessive synaptic loss during the prodromal phase of Alzheimer’s disease (AD) and is associated with lowered cyclic adenosine monophosphate (cAMP) due to cAMP phosphodiesterase 4B (PDE4B). This study aimed investigate whether long-term inhibition PDE4B by A33 (3 mg/kg/day) prevent synapse its cognitive decline in APPswe/PS1dE9 mice. model characterized a chimeric mouse/human APP Swedish mutation human PSEN1 lacking exon 9 (dE9), both under control mouse prion...
Current treatment options for Alzheimer’s disease (AD) are limited, inefficient and often have serious side effects. Oxytocin is a neuropeptide implicated in variety of central processes, such as social reproductive behaviors. Amongst others, it has garnered attention various domains psychiatric research, while its role the development course neurodegenerative disorders like AD rather unknown. This study aimed to investigate exogenous oxytocin administration on memory, specifically view AD,...