A5027622528- Analytical chemistry methods development
- Biosensors and Analytical Detection
- Advanced Chemical Sensor Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Analytical Chemistry and Sensors
- Organic Electronics and Photovoltaics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrochemical Analysis and Applications
- Pharmacological Effects and Assays
- Forensic Toxicology and Drug Analysis
- Conducting polymers and applications
- Analytical Chemistry and Chromatography
- Electrochemical sensors and biosensors
- Advanced biosensing and bioanalysis techniques
- Organic Light-Emitting Diodes Research
- Bacterial Identification and Susceptibility Testing
- Mass Spectrometry Techniques and Applications
- Molecular Junctions and Nanostructures
- Neuroscience and Neuropharmacology Research
- 3D Printing in Biomedical Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Chemical Synthesis and Analysis
- Hydrogels: synthesis, properties, applications
- Various Chemistry Research Topics
- Receptor Mechanisms and Signaling
Maastricht University
2016-2025
Hasselt University
2010-2014
Molecularly imprinted polymers (MIPs) have emerged over the past few decades as interesting synthetic alternatives due to their long-term chemical and physical stability low-cost synthesis procedure. They been integrated into many sensing platforms assay formats for detection of various targets, ranging from small molecules macromolecular entities such pathogens whole cells. Despite advantages MIPs natural receptors in terms commercialization, striking success stories biosensor applications...
Pseudomonas aeruginosa is a ubiquitous multi-drug-resistant bacterium, capable of causing serious illnesses and infections. This research focuses on the development thermal sensor for indirect detection P. infection using molecularly imprinted polymers (MIPs). was achieved by developing MIPs pyocyanin, main toxin secreted aeruginosa. To this end, phenazine used as dummy template, evaluating several polymeric compositions to achieve selective MIP pyocyanin recognition. The sensitivity...
Molecularly imprinted polymers (MIPs) have gained growing interest among researchers worldwide, due to their key features that make these materials interesting candidates for implementation as receptors into sensor applications. In fact, MIP-based glucose sensors could overcome the stability issues associated with enzymes present in commercial devices. Various reports describe successful development of MIPs and coupling a wide variety transducers creating are able detect various matrices....
This work focuses on the development of a label-free biomimetic sensor for specific and selective detection bacteria. The platform relies rebinding bacteria to synthetic cell receptors, made by surface imprinting polyurethane-coated aluminum chips. heat-transfer resistance (Rth) these so-called imprinted polymers (SIPs) was analyzed in time using method (HTM). Rebinding target receptor led measurable increase thermal at solid–liquid interface. Escherichia coli Staphylococcus aureus were used...
Glucose bio-sensing technologies have received increasing attention in the last few decades, primarily due to fundamental role that glucose metabolism plays diseases (e.g., diabetes). Molecularly imprinted polymers (MIPs) could offer an alternative means of analysis a field is traditionally dominated by enzyme-based devices, posing superior chemical stability, cost-effectiveness, and ease fabrication. Their integration into sensing devices as recognition elements has been extensively studied...
Abstract Glucose biosensors play an extremely important role in health care systems worldwide. Therefore, the field continues to attract significant attention leading development of innovative technologies. Due their characteristics, Molecularly Imprinted Polymers (MIPs) represent a promising alternative commercial enzymatic sensors. In this work, low‐cost, flexible MIP‐based platform for glucose sensing by integrating MIP particles directly into screen‐printed electrodes (SPEs) is realized....
Abstract Offering high specificity and selectivity, molecularly imprinted polymers (MIPs) are synthetic polymeric affinity reagents that have become increasingly popular over the last couple of decades. Due to their long‐term chemical physical stability low production cost, they an choice receptor in realm sense. MIPs therefore been associated with detection small molecules, proteins, cells, pathogens, proving a highly robust useful tool next‐gen sensing platforms. This said, development...
Polyfluoroalkyl substances (PFAS) have gained increasing negative attention in recent years owing to their potential carcinogenicity, neurotoxicity, and ability bio-accumulate wildlife, making rapid low-cost detection highly desirable. Molecularly Imprinted Polymers (MIPs) were therefore implemented as robust, cost-effective, selective affinity reagent a thermal sensing platform (the “Heat Transfer Method”), enabling the development of time-efficient sensor that is capable analyzing both...
The incorporation of imprinted polymers (IP) into sensing devices has enabled the detection a wide range analytes going from molecules to whole cells. Biomimetic platforms for bacteria recognition possess potential being low-cost and on-site testing technology applications in food safety, where accurate pathogens is crucial preventing disease. This work presents optimization label-free thermal IP-based sensor E. coli, microorganism indicator fecal contamination drinking water milk. By...
In recent years, melamine-sensing technologies have increasingly gained attention, mainly due to the misuse of molecule as an adulterant in milk and other foods. Molecularly imprinted polymers (MIPs) are ideal candidates for recognition melamine real-life samples. The prepared MIP particles were incorporated into a thermally conductive layer via micro-contact deposition its response towards was analyzed using heat-transfer method (HTM). sensor displayed excellent selectivity when analyzing...
Antibiotic resistance is a global health threat, challenging traditional treatments and complicating the food safety process. This study introduces an electrochemical detection method for streptomycin sulfate, utilizing gold screen-printed electrodes (Au-SPE) functionalized via electropolymerization of custom-made naphthalene diimide-based conjugated monomer (Th2-NDI-PIA). modification creates specific binding sites streptomycin, allowing rapid antibiotic. The sensor's response to different...
Ensuring a rapid and accurate identification of harmful bacteria is crucial in various fields including environmental monitoring, food safety, clinical diagnostics. Conventional detection methods often suffer from limitations such as long analysis time, complexity, the need for qualified personnel. Therefore, lot research effort devoted to developing technologies with potential revolutionize pathogenic by offering rapid, sensitive, user-friendly platforms point-of-care analysis. In this...
Malaria is a major public healthcare concern worldwide, representing leading cause of death in specific regions. The gold standard for diagnosis microscopic analysis, but this requires laboratory setting, trained staff, and infrastructure therefore typically slow dependent on the experience technician. This study introduces, first time, biomimetic sensing platform direct detection disease. heart sensor consists synthetic receptor created by surface imprinting Plasmodium falciparum-infected...
As the main inhibitory neurotransmission system, GABAergic system poses an interesting yet underutilized target for molecular brain imaging. While PET imaging of postsynaptic neurons has been accomplished using radiolabeled benzodiazepines targeting GABAA receptor, development presynaptic radioligands GABA transporter 1 (GAT1) unsuccessful thus far. Therefore, we developed a novel GAT1-addressing radioligand and investigated its applicability as tracer in rodents. We selected lipophilic...
This paper introduces a novel bacterial identification assay based on thermal wave analysis through surface-imprinted polymers (SIPs). Aluminum chips are coated with SIPs, serving as synthetic cell receptors that have been combined previously the heat-transfer method (HTM) for selective detection of bacteria. In this work, concept is extended toward nine different species. addition, sensing approach, transport (TWTA), introduced, which analyzes propagation functional interface. The results...
Molecularly imprinted polymers (MIPs), synthetic polymeric receptors, have been combined successfully with thermal transducers for the detection of small molecules in recent years. However, up until now they planar electrodes which limits their use vivo applications. In this work, a new biosensor platform is developed by roll-coating MIP particles onto thermocouples, functionalized polylactic acid (PLLA). As first proof-of-principle, MIPs neurotransmitter dopamine were incorporated into...
Hydrogels are interesting materials for application in biomedicine due to their outstanding properties (e.g., water retention, drug release, and biocompatibility). This work evaluates two series of phosphorus-based hydrogels as potential wound-dressing candidates. The were synthesized via free-radical polymerization bis[2-(methacryloyloxy)ethyl] phosphate (BMEP, ≥75 wt %) with (3-acrylamidopropyl)trimethylammonium chloride solution (APTAC) or 2-acrylamido-2-methyl-1-propane sulfonic acid...
This work presents an imprinted polymer-based thermal biomimetic sensor for the detection of Escherichia coli. A novel and facile bacteria imprinting protocol polydimethylsiloxane (PDMS) films was investigated, these receptor layers were functionalized with graphene oxide (GO) in order to improve overall sensitivity sensor. Upon recognition binding target densely polymers, a concentration-dependent measurable change temperature observed. The limit attained employing PDMS-GO imprints 80 ± 10...