A5045525252- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Parasitic Infections and Diagnostics
- Malaria Research and Control
- Parasites and Host Interactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Drug-Induced Hepatotoxicity and Protection
- Wound Healing and Treatments
- Sex work and related issues
- Antimicrobial Peptides and Activities
- Leprosy Research and Treatment
- Pain Mechanisms and Treatments
- Rabies epidemiology and control
- Transgenic Plants and Applications
- Hepatitis B Virus Studies
- Viral gastroenteritis research and epidemiology
- Hydrogels: synthesis, properties, applications
- vaccines and immunoinformatics approaches
- Bioactive Compounds and Antitumor Agents
- Immune responses and vaccinations
- Toxin Mechanisms and Immunotoxins
- Corneal Surgery and Treatments
Universidade Federal de Minas Gerais
2022-2025
Australian National University
2025
Universidade Federal do Rio Grande do Norte
2020-2023
Abstract Objectives The purpose of this study was to determine reference points for thermal perception in cutaneous lesions leprosy, a disease caused by Mycobacterium leprae characterised hypoesthesia skin due nerve and Schwann cell infection. Early diagnosis is essential control transmission effectively treat the disease. Methods Quantitative testing (QTT) has been proposed as valuable tool early detection disease, initiation treatment, monitoring damage. A analyser used warm cold...
Determining esophageal and colon involvement in patients with Chagas disease occurs through invasive uncomfortable examinations, which most cases are not performed. The objective of this study was to assess the anti-M2-pyruvate kinase (M2-PK) autoantibodies development digestive alterations and/or diagnosis form human disease. total IgG isotype (IgG1, IgG2, IgG3, IgG4) production quantified using antigen Trypanosoma cruzi M2-PK recombinant protein via ELISA technique. tests were conducted...
Malaria is a major public healthcare concern worldwide, representing leading cause of death in specific regions. The gold standard for diagnosis microscopic analysis, but this requires laboratory setting, trained staff, and infrastructure therefore typically slow dependent on the experience technician. This study introduces, first time, biomimetic sensing platform direct detection disease. heart sensor consists synthetic receptor created by surface imprinting Plasmodium falciparum-infected...
BACKGROUND Toxocariasis is a neglected global zoonosis. The immunological diagnosis has setbacks that hinder further knowledge about its pathology, epidemiology, and public control measures, lack of financial support attention prevents innovative research. Although studies on synthetic peptides are common for several infectious pathologies, none evaluated chemically toxocariasis diagnosis. OBJECTIVE This study aimed to identify potential from C-type lectin 1 (Tc-CTL-1) Toxocara canis....
Malaria, caused by Plasmodium vivax, remains a major global health problem, particularly in tropical and subtropical regions. This study aimed to investigate the potential of PvVir14-derived peptides improve diagnostic accuracy for P. vivax infections. The reactivity specific against sera from acutely infected individuals endemic non-endemic areas experiencing malaria outbreak was assessed, as well their sensitivity, specificity, immunodominance. Among eight tested (H08, K09, I03, G08, F08,...
Abstract Toxoplasma gondii is an intracellular parasite with a worldwide distribution. infections are of great concern for public health, and their impact usually most severe in pregnant women foetuses, immunocompromised individuals. Displaying considerable genetic diversity, T. strains differ widely according to geographical location, archetypal predominantly found the Northern Hemisphere non-archetypal (atypical) strains, highly diverse genotypes, mainly South America. In this review, we...
Toxoplasma gondii chronic infection is characterized by the establishment of tissue cysts in brain and increased levels IFN-γ, which can lead to circuitry interference consequently abnormal behaviour mice. In this sense, study presented here sought investigate impact two T. strains infection-resistant mice, as a model for studying involvement neuroinflammation with development behavioural alterations. For that, male BALB/c mice were divided into three groups: non-infected (Ni), infected ME49...
Alveolar macrophages (AM) and monocytes (MO) are myeloid cells that play a substantial role in the development establishment of innate adaptive immune response. These crucial for host defense against various pathogens, but their malaria is poorly understood. Here, we characterize dynamics AMs recruited leukocytes subpopulations airways during experimental Plasmodium berghei NK65-NY (PbNK65). We show PbNK65 infection induces an increased pulmonary vascular permeability provides Ly6Clow MOs,...
Chikungunya virus (CHIKV) is an arbovirus causing acute febrile illness with severe joint pain, often leading to chronic arthralgia. This study investigated the adaptive immune responses during early stages of symptomatic CHIKV infection, focusing on transcription factors and cytokines linked Th1, Th2, Th17, Treg cells. Thirty-six individuals were enrolled: nine healthy controls 27 CHIKV-positive patients confirmed by qRT-PCR. Blood samples analyzed for mRNA expression (Tbet, GATA3, FoxP3,...
Behavioral and neurochemical alterations associated with toxoplasmosis may be influenced by the persistence of tissue cysts activation an immune response in brain Toxoplasma gondii-infected hosts. The cerebral extracellular matrix is organised as perineuronal nets (PNNs) that are both released ensheath some neurons glial cells. There evidences to suggest PNNs impairment a pathophysiological mechanism neuropsychiatric conditions. However, there lack information regarding impact parasitic...
In the fight against malaria, key is early treatment with antimalarial chemotherapy, such as artemisinin-based combination treatments (ACTs). However, Plasmodium has acquired multidrug resistance, including emergence of P. falciparum strains resistance to ACT. The development novel molecules, that are capable interfering in asexual and sexual blood stages, important slow down transmission endemic areas. this work, we studied ability mettalo copper-cinchonine complex interfere stages . tested...
Abstract Toxoplasma gondii is able to manipulate the host immune system establish a persistent and efficient infection, contributing development of brain abnormalities with behavioral repercussions. In this context, work aimed evaluate effects T. infection on systemic inflammatory response structure primary somatosensory cortex (PSC). C57BL/6 BALB/c mice were infected ME49 strain tissue cysts accompanied for 30 days. After period, levels cytokines IFN-γ, IL-12, TNF-α TGF-β measured. blood...
The impact of Schistosoma mansoni infection over the immune response and mechanisms involved in pathogenesis are not yet completely understood.
Wound healing is important for skin after deep injuries or burns, which can lead to hospitalization, long-term morbidity, and mortality. In this field, tissue-engineered substitutes have therapy potential assist in the treatment of acute chronic wounds, where many requirements are still unmet. Hence, study, a novel type biocompatible ternary polymer hybrid hydrogel scaffold was designed produced through an entirely eco-friendly aqueous process composed carboxymethyl cellulose, chitosan,...