A5091560354- Molecular Biology Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Parasites and Host Interactions
- Parasitic Infections and Diagnostics
- Malaria Research and Control
- Parasite Biology and Host Interactions
- Orthopaedic implants and arthroplasty
- Toxoplasma gondii Research Studies
- Helminth infection and control
- CRISPR and Genetic Engineering
- Pediatric health and respiratory diseases
- Parasitic infections in humans and animals
- Immune Cell Function and Interaction
- Immune cells in cancer
- Educational Practices and Policies
- Animal Genetics and Reproduction
- Cytomegalovirus and herpesvirus research
- Science and Education Research
- IL-33, ST2, and ILC Pathways
- Education and Public Policy
- Education Pedagogy and Practices
- Insects and Parasite Interactions
- RNA Research and Splicing
- Orthopedic Infections and Treatments
- Gut microbiota and health
Universidade Federal de Minas Gerais
2022-2025
Universidade Federal do Rio Grande do Norte
2023
Toxoplasma gondii chronic infection is characterized by the establishment of tissue cysts in brain and increased levels IFN-γ, which can lead to circuitry interference consequently abnormal behaviour mice. In this sense, study presented here sought investigate impact two T. strains infection-resistant mice, as a model for studying involvement neuroinflammation with development behavioural alterations. For that, male BALB/c mice were divided into three groups: non-infected (Ni), infected ME49...
Alveolar macrophages (AM) and monocytes (MO) are myeloid cells that play a substantial role in the development establishment of innate adaptive immune response. These crucial for host defense against various pathogens, but their malaria is poorly understood. Here, we characterize dynamics AMs recruited leukocytes subpopulations airways during experimental Plasmodium berghei NK65-NY (PbNK65). We show PbNK65 infection induces an increased pulmonary vascular permeability provides Ly6Clow MOs,...
Abstract Analyzing the stability of reference genes already described as universal is an important methodology to lead gene expression analysis because different studies have shown that may vary between experimental treatments. In this sense, glyceraldehyde 3-phosphate dehydrogenase (GAPDH), Succinate complex subunit A (SDHA) and Ribosomal Protein L-19 (RPL-19) (already in other with sheep from regions, breeds infectious agents or organisms evolutionarily close sheep) were investigated...
IL-17 is a cytokine produced by innate and acquired immunity cells that have an action against fungi bacteria. However, its in helminth infections unclear, including Toxocara canis infection. Toxocariasis neglected zoonosis representing significant public health problem with estimated seroprevalence of 19% worldwide. In the present study, we describe immunopathological IL-17RA acute T. C57BL/6j (WT) receptor knockout (IL-17RA-/-) mice were infected 1000 eggs. Mice evaluated 3 days...
The 4T1 model is extensively employed in murine studies to elucidate the mechanisms underlying carcinogenesis of triple-negative breast cancer. Molecular biology serves as a cornerstone these investigations. However, accurate gene expression analyses necessitate data normalization employing housekeeping genes (HKGs) avert spurious results. Here, we initially delve into characteristics tumor evolution induced by mice, underscoring imperative for additional tools monitoring and assessment...
Background Human ascariasis is the most prevalent geohelminthiasis worldwide, affecting approximately 446 million individuals. In regions with endemic prevalence, majority of infected adults are frequently exposed to parasite and tend have a low load. Further studies necessary provide more evidence on dynamics infection elucidate possible mechanisms involved in regulating protection, especially during acute phase, also known as larval ascariasis. The aim this study compare impact lung...
Abstract An increase in peripheral blood eosinophils helminth infections is expected, and these cells are known to promote immunity against parasites. However, studies have suggested that some specific helminths, may the needs longevity of parasites, their role remains undefined, including Toxocara canis infection. Thus, this study aimed investigate context larval migration T. immunopathological aspects For this, we used wild-type mice genetically deficient for transcription factor...
Human ascariasis is the most prevalent helminth infection, affecting 445 million people worldwide. To better understand impact of immune system on pathophysiology individuals infected with Ascaris suum, mice have been used as experimental models. The RT-qPCR technique a critical auxiliary tool investigation to quantify mRNA levels. However, proper normalization using reference genes essential ensure reliable outcomes avoid analytical errors and false results. Despite importance for A. suum...