A5087276445- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Helminth infection and control
- Parasitic infections in humans and animals
- IL-33, ST2, and ILC Pathways
- Global Maternal and Child Health
- Mosquito-borne diseases and control
- Dermatological diseases and infestations
- Reproductive System and Pregnancy
- Complement system in diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Child Nutrition and Water Access
- Virology and Viral Diseases
- Parasitic Infections and Diagnostics
- Malaria Research and Control
- Parasitic Diseases Research and Treatment
- Food Allergy and Anaphylaxis Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Esophagitis
Universidade Federal de Minas Gerais
2013-2024
Nematodes of the genus Toxocara are cosmopolitan roundworms frequently found in dogs and cats. spp. can accidentally infect humans cause a zoonosis called human toxocariasis, which is characterized by visceral, ocular or cerebral migration larval stages parasite, without completing its life cycle. In general, chronic nematode infections induce polarized TH2 immune response. However, during initial phase infection, strong pro-inflammatory response part immunological profile might determine...
Human ascariasis has a global and cosmopolitan distribution, been characterized as the most prevalent neglected tropical disease worldwide. The development of preventive vaccine is highly desirable to complement current measures required for this parasitic infection control reduce chronic childhood morbidities. In present study, we describe mechanism protection elicited by against ascariasis. Vaccine efficacy was evaluated after immunization with three different Ascaris suum antigen extracts...
Ascariasis remains the most common helminth infection in humans. As an alternative or complementary approach to global deworming, a pan-anthelminthic vaccine is under development targeting Ascaris, hookworm, and Trichuris infections. As16 As14 have previously been described as two genetically related proteins from Ascaris suum that induced protective immunity mice when formulated with cholera toxin B subunit (CTB) adjuvant, but exact mechanism was not well understood.As16 were highly...
Ascariasis is considered the most neglected tropical disease, and a major problem for public health system. However, idiopathic pulmonary fibrosis (IPF) result of chronic extracellular deposition matrix in parenchyma, thickening alveolar septa, which reduces gas exchange. Considering high rates ascariasis fibrosis, we believe that these two diseases may co-exist possibly lead to comorbidities. We therefore investigated mechanisms involved comorbidity Ascaris suum (A. suum) infection, could...
Human ascariasis is the most prevalent but neglected tropical disease in world, affecting approximately 450 million people. The initial phase of Ascaris infection marked by larval migration from host's organs, causing mechanical injuries followed an intense local inflammatory response, which characterized mainly neutrophil and eosinophil infiltration, especially lungs. During pulmonary phase, lesions induced excessive immune responses contribute to tissue remodeling fibrosis lung...
Reduction in the number of circulating blood lymphocytes (lymphocytopaenia) has been reported during clinical episodes malaria and is normalized after treatment with anti-malaria drugs. While this phenomenon well established infection, underlying mechanisms are still not fully elucidated. In present study, occurrence apoptosis its pathways CD4+ T cells was investigated naturally Plasmodium vivax-infected individuals from a Brazilian endemic area (Porto Velho - RO).Blood samples were...
Ascariasis is one of the most common infections in world and associated with significant global morbidity. Ascaris larval migration through host's lungs essential for development but leads to an exaggerated type-2 host immune response manifesting clinically as acute allergic airway disease. However, whether can subsequently lead chronic lung diseases remains unknown. Here, we demonstrate that a single episode induces pulmonary syndrome inflammatory pathology emphysema accompanied by...
Control of human ascariasis, the most prevalent neglected tropical disease globally affecting 450 million people, mostly relies on mass drug administration anthelmintics. However, chemotherapy alone is not efficient due to high re-infection rate for people who live in endemic area. The development a vaccine that reduces intensity infection and maintains lower morbidity should be primary target control. Previously, our group demonstrated immunization with crude Ascaris antigens mice induced...
Ascariasis is a neglected tropical disease that widespread in the world and has important socioeconomic impacts. The presence of various stages worm development pulmonary intestinal mucosae induces humoral cellular immune response. However, although there much evidence protective role mucosal immunity against pathogens, including helminths, still gap knowledge about response mechanisms action are involved protection diseases, especially initial phase ascariasis. Thus, aim this study was to...
Abstract Human ascariasis is the most common and prevalent neglected tropical disease estimated that ~819 million people are infected around globe, accounting for 0.861 years of disability-adjusted life in 2017. Even with existence highly effective drugs, constant presence infective parasite eggs environment contribute to a high reinfection rate after treatment. Due its prevalence broad geographic distribution Ascaris infection associated variety co-morbidities co-infections. Here, we...
Background Human ascariasis is the most prevalent geohelminthiasis worldwide, affecting approximately 446 million individuals. In regions with endemic prevalence, majority of infected adults are frequently exposed to parasite and tend have a low load. Further studies necessary provide more evidence on dynamics infection elucidate possible mechanisms involved in regulating protection, especially during acute phase, also known as larval ascariasis. The aim this study compare impact lung...