A5001815687- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Helminth infection and control
- Research on Leishmaniasis Studies
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Global Maternal and Child Health
- Asthma and respiratory diseases
- Parasitic infections in humans and animals
- Parasitic Infections and Diagnostics
- Parasitic Diseases Research and Treatment
- Child Nutrition and Water Access
- Zoonotic diseases and public health
- Mollusks and Parasites Studies
- Malaria Research and Control
- Trypanosoma species research and implications
- Monoclonal and Polyclonal Antibodies Research
- Animal testing and alternatives
- Leprosy Research and Treatment
- Digital Imaging for Blood Diseases
- Inflammatory Bowel Disease
- Papaya Research and Applications
- Insects and Parasite Interactions
- Dermatological diseases and infestations
- Macrophage Migration Inhibitory Factor
Universidade Federal de Minas Gerais
2015-2025
Institute of Parasitology
2005-2007
Fundação Oswaldo Cruz
2004
Cornell University
1996-1999
New York State College of Veterinary Medicine
1996
Several lines of evidence have shown that helminthiasis can significantly reduce disease severity in animal models intestinal inflammation, airway inflammation/hyperreactivity, diabetes, and multiple sclerosis. Identification characterization helminth-derived immunomodulatory molecules contribute to anticolitis effects could lead new therapeutic approaches inflammatory bowel diseases (IBDs) without the need for helminth infection. We evaluated potential adult human hookworm, Ancylostoma...
Background In some tropical countries, such as Brazil, schistosomiasis control programs have led to a significant reduction in the prevalence and parasite burden of endemic populations. this setting, Kato-Katz technique, standard diagnostic method for diagnosis Schistosoma mansoni infections, which involves analysis two slides from one fecal sample, loses its sensitivity. As result, number infected individuals are not detected. The objective study was perform extensive parasitological...
Folk medicine reports have described the use of Chenopodium ambrosioides as an anti-inflammatory, analgesic, and anthelmintic herb. These effects, including its activity against intestinal worms, are already scientifically observed. However, immunological mechanisms this species in treatment Schistosoma mansoni infection unknown. Aim study: To evaluate anti-Schistosoma effects a crude hydro-alcoholic extract (HCE). For vitro analysis, cercariae adult worms were exposed to different...
A cross-sectional study was conducted on a randomised sample of 405 children aged 6–71 months in Brazil to investigate the association between nutritional status, environmental and socio-economic factors Giardialamblia infection. Data collection entailed an interview, anthropometric measurements faeces venous blood samples. The analysis performed using multivariate logistic regression. prevalence rate for G. lamblia 26.3%. Nutritional status evaluation showed that 7.9% had chronic...
BackgroundEvidence suggests that biological mechanisms involved in helminth infections and vitamin deficiencies increase susceptibility to other infections. The aim of this study was investigate the associations co-infection select micronutrient with leprosy using a case–control design.MethodsFrom 2016 2018, individuals aged ≥3 years were recruited at clinics around Governador Valadares, Minas Gerais, Brazil three groups: cases leprosy, household contacts community-matched (non-contact)...
Schistosomiasis is a neglected tropical disease (NTD) caused by blood flukes from the genus Schistosoma. Brazil hosts main endemic area in Americas, where Schistosoma mansoni only species causing disease. Kato-Katz (KK) thick smear WHO recommended screening test for populational studies, but there growing evidence sensitivity limitations associated with KK, especially areas low parasite loads. Helmintex (HTX) another highly sensitive egg-detection method, based on magnetic properties of S....
The prevalence of allergic diseases such as asthma has increased markedly over the past few decades. To evaluate possible mutual influence helminth infection and allergy, combined effects experimental airway inflammation with Strongyloides venezuelensis on various parasitological inflammatory indices were evaluated in rat. A challenge immunized rats aerosolized ovalbumin (OVA) resulted eosinophilic that peaked 48 h after was accompanied by hyperresponsiveness (AHR) to an intravenous...
One of the most important drawbacks in visceral leishmaniasis (VL) population studies is difficulty diagnosing asymptomatic carriers. The aim this study, conducted an urban area Southeast Brazil, was to evaluate performance serology identify VL infection participants selected from a cohort with two-year follow-up period.
Background Studies in murine models and human populations have indicated that the collagen-rich granulomatous response against parasite eggs trapped liver is associated with development of severe hepatosplenic schistosomiasis, characterized by periportal fibrosis portal hypertension. The role humoral susceptibility has been well established, but its participation disease severity remains poorly understood. In this work, we evaluated relationship between parasite-reactive IgE IgG levels...
Abstract Due to the efforts control schistosomiasis transmission in tropical countries, a large proportion of individuals from endemic areas present low parasite loads, which hinders diagnosis intestinal by Kato-Katz (KK) method. Therefore, development more sensitive diagnostic methods is essential for efficient measures. The aim was evaluate accuracy real-time polymerase chain reaction (RT-PCR) detect Schistosoma mansoni DNA fecal samples with loads. A cross-sectional population-based study...
Abstract Background Schistosomiasis continues to represent a serious public health problem in Brazil. With the coronavirus disease 2019 (COVID-19) pandemic, several control strategies were suspended, probably compromising goals of eradicating country. We aimed assess impact COVID-19 pandemic on Control Program (PCE) actions all endemic states Methods performed an ecological study using spatial analysis techniques. The PCE variables assessed population surveyed, number Kato–Katz tests,...
Abstract Objectives Schistosomiasis and tegumentary leishmaniasis simultaneously affect areas in tropical subtropical regions. Co‐infected individuals show a less‐than‐optimal response to treatment increased regulatory immune responses. However, no study has determined where Schistosoma – Leishmania co‐infections are more likely occur. Methods Data from The Global Health Observatory were collected determine the worldwide endemicity status of schistosomiasis 2023. To co‐endemic at local...
ABSTRACT Infection by nematode parasites with a pulmonary migration in their life cycle and allergic asthma are two highly prevalent diseases humans; therefore, one may expect both occur concomitantly. There is predominant essential role of Th2 lymphocytes the mechanisms underlying control parasite elimination as well pathology observed asthmatic lung. The consequences such situations have been explored, controversial results, justifying development experimental models which relationship...
Abstract Previous work has shown that Trichinella spiralis-infected rats transport IgE from plasma to intestinal tissue and fluids. In this study we quantitate the gut circulation during T. spiralis infection in rats. Total levels fluid infected were elevated by 4 days post-infection (dpi), but not serum lymph until 7 dpi. ranged 1 6 microg between 10 21 dpi, 100 200 ng/ml. Immunoprecipitation of enterocyte lysate at 11 dpi showed a protein 190 kDa was recognized mouse anti-rat IgE-MARE-1...
Human infection by Schistosoma mansoni affects more than 100 million people worldwide, most often in populations of developing countries Africa, Asia, and Latin America. The transmission S. human depends on the presence some species Biomphalaria that act as an intermediate host. compatibility between its host is influenced behavioral, physiological, genetical factors mollusc parasite. susceptibility level has been attributed to capacity internal defense system (IDS)—hemocytes soluble...
Studies performed in the last 30 years demonstrated that a strain of B. tenagophila from Taim Biological Reserve is completely resistant to Schistosoma mansoni infection. This resistance parasite infection dominant characteristic during crossbreeding with susceptible strains. These experiments also identified 350 bp molecular marker exclusive and does not occur other geographic strains this snail species. The (Taim/RS) Biomphalaria was bred on large scale, physically marked introduced into...
Iron deficiency anemia is one of the most common nutritional disorders worldwide. The aim was to identify prevalence and incidence in children predictors this condition, including intestinal parasites, social, environmental factors, comorbidities. A population-based cohort study conducted a sample 414 aged 6–71 months living Novo Cruzeiro Minas Gerais State. Data were collected 2008 2009 by interview included socio-economic demographic information about their families. Blood samples for...
Helminth infections and allergies are characterized by a predominant type-2 immune response. In schistosomiasis, the Th-2 response is usually accompanied induction of immunoregulatory mechanisms that contribute to worm survival less severe schistosomiasis. Although helminth-induced immunomodulatory seem affect atopy, epidemiological studies on relationship between helminths allergy have been inconsistent, data suggest modulatory effects may be influenced helminth species, chronicity...