A5057664572- Parkinson's Disease Mechanisms and Treatments
- Fluoride Effects and Removal
- Free Radicals and Antioxidants
- Photochromic and Fluorescence Chemistry
- Pesticide Exposure and Toxicity
- Infant Nutrition and Health
- Viral Infectious Diseases and Gene Expression in Insects
- Molecular Biology Techniques and Applications
- Quantum Dots Synthesis And Properties
- Animal Genetics and Reproduction
- DNA Repair Mechanisms
- Dental Health and Care Utilization
- Fungal Plant Pathogen Control
- Plant Pathogens and Resistance
- Ginkgo biloba and Cashew Applications
- thermodynamics and calorimetric analyses
- Plant-Microbe Interactions and Immunity
- CRISPR and Genetic Engineering
- Neurobiology and Insect Physiology Research
- Nanoparticle-Based Drug Delivery
- Insect and Pesticide Research
- Nutritional Studies and Diet
- Fungal and yeast genetics research
- Organic Chemistry Cycloaddition Reactions
- bioluminescence and chemiluminescence research
Universitätsmedizin Göttingen
2024-2025
University of Minho
2016-2025
Universidade Federal de Minas Gerais
2024
Universidade dos Açores
2016-2017
Universidade Nova de Lisboa
2014-2015
Due to increasing demand for high and stable crop production, human populations are highly dependent on pesticide use growing storing food. Environmental monitoring of these agrochemicals is therefore utmost importance, because their collateral effects ecosystem health. Even though most current-use analytical methods achieve low detection limits, they require procedures that too complex costly routine monitoring. As such, there has been an increased interest in biosensors as alternative or...
Bovine lactoferrin (bLf) is a milk-derived protein that exhibits multiple biological activities and has been explored towards different therapeutic applications. Since this molecule susceptible to degradation some of its properties depend on tertiary structure, the encapsulation bLf in stimuli-responsive formulations provides an added value potentiate when administered. Plasmonic magnetoliposomes emerge as promising nanosystems for dual hyperthermia (magneto-photothermia) local therapy,...
Abstract Worldwide use of agrochemicals, particularly pesticides, is necessary to increase agricultural production feed the ever-growing population. However, despite widespread use, biochemical mode action many agrochemicals and their potential deleterious effects on environment are poorly characterized. Cymoxanil (CYM) a fungicide used combat downy mildew diseases in grapevine cultures late blight tomato potato caused by oomycetes Plasmopara viticola Phytophthora infestans , respectively....
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons and presence Lewy bodies, which predominantly consist aggregated forms protein alpha-synuclein (aSyn). While these aggregates are pathological hallmark PD, etiology most cases remains elusive. Although environmental risk factors have been identified, such as pesticides dieldrin MTPT, many others remain to be assessed their molecular impacts underexplored. This study aimed identify that...
Bovine lactoferrin (bLf) is a milk-derived protein that exhibits potent broad-spectrum antifungal activity against multiple fungi. bLf susceptible to degradation, while some of its properties depend on the tertiary structure. So, encapsulation in stimuli-responsive therapeutic formulations provides an added value enhance biological activities. Plasmonic magnetoliposomes (PMLs) arise as promising nanocarriers for dual hyperthermia (magneto-photothermia) and local chemotherapy, since...
Cisplatin is a widely used antineoplastic agent that has DNA as the main target, though cellular resistance hampers its therapeutic efficacy. An emerging hallmark of cancer cells their altered metabolism, characterized by increased glycolysis even under aerobic conditions, with lactate production (known Warburg effect). Although this metabolism often results in to chemotherapy, it also provides an opportunity for targeted intervention. It been suggested cisplatin cytotoxicity can be affected...
The 4T1 model is extensively employed in murine studies to elucidate the mechanisms underlying carcinogenesis of triple-negative breast cancer. Molecular biology serves as a cornerstone these investigations. However, accurate gene expression analyses necessitate data normalization employing housekeeping genes (HKGs) avert spurious results. Here, we initially delve into characteristics tumor evolution induced by mice, underscoring imperative for additional tools monitoring and assessment...
Over-expressed efflux pumps of cancer cells frequently contribute to the failure chemotherapy. These proteins are responsible for extrusion a large variety unrelated chemically distinct compounds that toxic cell. Hence their increased presence leads multi-drug resistant (MDR) phenotype. Ecdysteroids analogues insect hormones occur in plants. not recognized by human steroid receptors. Some mild beneficial bioactivities have been described and led worldwide marketing ecdysteroid containing...
Ecdysteroids are known as regulators of moulting and reproduction in arthropods, they can also be found many plants defensive agents against herbivores [1]. Our research group has recently reported their adjuvant antitumor activity combination with various chemotherapeutics on several cancer cell lines, by studying fourteen 20,22-, seventeen 2,3;20,22- two 2,3-dioxolane derivatives semi-synthesized from 20-hydroxyecdysone (20E) [2 – 4].