A5100764203- Synthesis and Reactions of Organic Compounds
- Natural product bioactivities and synthesis
- Synthesis of Organic Compounds
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Analysis
- Synthesis and Biological Evaluation
- Organophosphorus compounds synthesis
- Asymmetric Synthesis and Catalysis
- Organic Chemistry Cycloaddition Reactions
- Phytochemistry and Biological Activities
- Carbohydrate Chemistry and Synthesis
- Plant biochemistry and biosynthesis
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Characterization of Heterocyclic Compounds
- Glycosylation and Glycoproteins Research
- Mass Spectrometry Techniques and Applications
- Oxidative Organic Chemistry Reactions
- Synthesis of heterocyclic compounds
- Molecular spectroscopy and chirality
- Synthesis and characterization of novel inorganic/organometallic compounds
- Chemical Synthesis and Reactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Proteoglycans and glycosaminoglycans research
- Synthesis and Reactivity of Heterocycles
- Synthesis and Catalytic Reactions
Budapest University of Technology and Economics
2011-2025
Cleveland Clinic
2023-2024
University of Szeged
2009-2024
Uppsala University
2023-2024
Eötvös Loránd University
1993-2023
HUN-REN Research Centre for Natural Sciences
2016-2023
Institute of Organic Chemistry
1979-2023
University of Pecs
2023
Research Network (United States)
2021-2023
Hungarian Research Network
2021-2023
Although photosensitizers, molecules that produce active oxygen species upon activation by visible light, are being extensively used in photodynamic therapy to treat cancer and other clinical conditions, problems include normal cell tissue damage associated side effects, which attributable part the fact cytotoxic effects largely restricted plasma membrane. We have previously shown photosensitizer chlorin e<sub>6</sub> has significantly higher photosensitizing activity when present conjugates...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTopographically designed analogs of [cyclic] [D-Pen2,D-Pen5]enkephalinVictor J. Hruby, Geza Toth, Catherine A. Gehrig, Lung Fa Kao, Richard Knapp, George K. Lui, Henry I. Yamamura, Thomas H. Kramer, P. Davis, and F. BurksCite this: Med. Chem. 1991, 34, 6, 1823–1830Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June...
Red yeast rice (angkak, red koji) obtained as cultures of Monascus purpureus on was extracted and analyzed by HPLC. In addition to the known red, orange, yellow pigments mycotoxin citrinin, a new metabolite detected. It is present in original formed higher amounts when heated. High-resolution mass spectrometry indicated molecular formula C(15)H(12)O(4). The chemical structure elucidated analysis NMR data. compound, named monascodilone, characterized propenyl group pyrone ring, an aromatic...
Objectives. The authors have previously identified a peptide of the human muscarinic acetylcholine receptor-3 (m3AChR) as suitable antigen for immunodetection antimuscarinic receptor autoantibodies in primary Sjögren's syndrome (pSS). aim this study was to assess clinical correlations and disease specificity these antibodies.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRing expansion in the addition of dichlorocarbene to 2,5-dihydro-1H-phosphole 1-oxidesGyorgy Keglevich, Imre Petnehazy, Peter Miklos, Attila Almasy, Gabor Toth, Laszlo Toke, and Louis D. QuinCite this: J. Org. Chem. 1987, 52, 18, 3983–3986Publication Date (Print):September 1, 1987Publication History Published online1 May 2002Published inissue 1 September...
Lung cancer is one of the most commonly diagnosed types. Studying molecular changes that occur in lung important to understand tumor formation and identify new therapeutic targets early markers disease decrease mortality. Glycosaminoglycan chains play roles various signaling events microenvironment. Therefore, we have determined quantity sulfation characteristics chondroitin sulfate heparan formalin-fixed paraffin-embedded human tissue samples belonging different types as well adjacent...
Unambiguous molecular annotation in mass spectrometry imaging is essential for understanding complex biochemical processes. Here, we present Parallel Image Acquisition (PIA), simultaneous with high resolution and tandem spectrometry, Spatial Similarity Network (SSN), to annotate isobars isomers reveal colocalization. With PIA SSN uncover phospholipid mouse brain tissue derive cholesterol oxidation metabolites linked multiple sclerosis.
Central nervous system (CNS) tumors are exceptionally difficult to treat, and oxidative stress-inducing radiotherapy is an important treatment modality. In this study, we examined self-assembling pro-drug nanoconjugates of naturally derived antitumor ecdysteroids, which were designed interfere with stress in brain tumor cells. Eight ecdysteroid-squalene conjugates semi-synthesized formulated into self-assembled aqueous nanosuspensions, showed excellent stability for up 16 weeks. The...
Efficient phosphoproteomic analysis of small amounts biological samples (e.g. tissue biopsies) requires carefully selected enrichment and purification steps prior to the nanoflow HPLC-MS/MS analysis. Solid-phase extraction (SPE) is one most commonly used approaches for sample preparation. Several stationary phases are available peptide SPE purification, however, published methods not optimized provide good recoveries phosphorylated peptides. Our goal was investigate performance 13...
Photosensitizers, molecules that produce active oxygen species upon activation by visible light, are currently being used in photodynamic therapy (PDT) to treat cancer and other conditions, where limitations include normal cells tissue damage associated side effects, the fact cytotoxic effects largely restricted plasma peripheral membranes. In this study, we insulin-containing conjugates which variants of simian-virus-SV40 large-tumor antigen (T-ag) nuclear localization signal (NLS) were...
Exendin-4 (Ex4) is a potent glucagon-like peptide-1 receptor agonist, drug regulating the plasma glucose level of patients suffering from type 2 diabetes. The molecule's poor solubility and its readiness to form aggregates increase likelihood unwanted side effects. Therefore, we designed Ex4 analogues with improved structural characteristics better water solubility. Rational design was started parent 20-amino acid, well-folded Trp cage (TC) miniprotein involved step-by-step N-terminal...
Abstract We have characterized site-specific N -glycosylation of the HeLa cell line glycoproteins, using a complex workflow based on high and low energy tandem mass spectrometry glycopeptides. The objective was to obtain highly reliable data common glycoforms, so rigorous evaluation performed. analysis revealed presence amount bovine serum contaminants originating from culture media – nearly 50% all glycans were origin. Unaccounted, components causes major bias in human cellular...
Lung cancer is one of the most common types with limited therapeutic options, therefore a detailed understanding underlying molecular changes utmost importance. In this pilot study, we investigated proteomic and glycosaminoglycan (GAG) profile ALK rearranged lung tumor tissue regions based on morphological classification, mucin stromal content. Principal component analysis hierarchical clustering revealed that both GAG-omic profiles are highly dependent content to lesser extent morphology....
Background: Intrinsically disordered proteins and protein regions (IDPs/IDRs) are important in diverse biological processes. Lacking a stable secondary structure, they display an ensemble of conformations. One factor contributing to this conformational heterogeneity is the proline cis/trans isomerization. The knowledge value given ratio paramount, as different states can be responsible for functions. Nuclear Magnetic Resonance (NMR) spectroscopy only method characterize two co-existing...