A5040867659- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Insect symbiosis and bacterial influences
- Parasites and Host Interactions
- Toxin Mechanisms and Immunotoxins
- Viral Infections and Immunology Research
- Parasitic Infections and Diagnostics
- Helminth infection and control
- Lysosomal Storage Disorders Research
- Insect Pest Control Strategies
- Vector-borne infectious diseases
- Mosquito-borne diseases and control
- Cardiomyopathy and Myosin Studies
- Insects and Parasite Interactions
- Vector-Borne Animal Diseases
- Cardiovascular Conditions and Treatments
- Respiratory viral infections research
- Insect Resistance and Genetics
- Synthesis and Biological Evaluation
- Whipple's Disease and Interleukins
- Biochemical and Molecular Research
- Nematode management and characterization studies
Universidade Federal do Rio Grande do Norte
2015-2025
Universidade Federal de Minas Gerais
2010
Determining esophageal and colon involvement in patients with Chagas disease occurs through invasive uncomfortable examinations, which most cases are not performed. The objective of this study was to assess the anti-M2-pyruvate kinase (M2-PK) autoantibodies development digestive alterations and/or diagnosis form human disease. total IgG isotype (IgG1, IgG2, IgG3, IgG4) production quantified using antigen Trypanosoma cruzi M2-PK recombinant protein via ELISA technique. tests were conducted...
Dogs are the main domestic reservoir host of parasite Trypanosoma cruzi, causative agent Chagas disease, and they considered sentinel animals for detection new cases human infection. Canis familiaris is also a well-established experimental T. cruzi infection model, but little known about progression disease in naturally-infected dogs, especially during acute phase these hosts. Triatomine species infected with discrete typing units (DTUs) I, II III have been previously found many...
Background The factors influencing variation in the clinical forms of Chagas disease have not been elucidated; however, it is likely that genetics both host and parasite are involved. Several studies attempted to correlate T. cruzi strains involved infection with by using hemoculture and/or PCR-based genotyping parasites from infected human tissues. However, techniques limitations hamper analysis large numbers samples. goal this work was identify conserved polymorphic linear B-cell epitopes...
Trypanosoma cruzi genetic diversity was investigated in 25 isolates (vectors and humans) from the semiarid zone of State Rio Grande do Norte, Brazil. Molecular markers (3' region 24Salpha rRNA; mitochondrial cytochrome oxidase subunit 2 (COII) gene; spliced leader intergenic (SL-IR) allelic size microsatellite polymorphism) identified 56% TcIII (100% Panstrongyluslutzi; 50% Triatomabrasiliensis); 40% TcII (91.7% humans; T. brasiliensis) 4% TcI (human). Microsatellite analysis revealed...
INTRODUCTION Natural and artificial ecotope infestation by the kissing bug triatomines their colonization infection Trypanosoma cruzi , Chagas disease agent, were evaluated in nine municipalities of State Rio Grande do Norte, Brazil. METHODS Following identification, triatomine intestinal contents analyzed direct microscopic examination, xenoculture, polymerase chain reaction (PCR) for parasite detection. isolates genotyped using three different markers. RESULTS Of 842 captured, 65% Triatoma...
Trypanosoma cruzi is subdivided into six discrete typing units (DTUs), TcI-TcVI. The precise identification of each can contribute to tracking wild DTUs that invade the domiciliary environment.Twenty T. stocks isolated from 16 chagasic patients, two Panstrongylus lutzi, one Galea spixii, and Euphractus sexcinctus, different localities in State Rio Grande do Norte, Brazil, were characterized by genotyping 3' region 24Sα rRNA gene, mitochondrial cytochrome oxidase subunit 2 spliced leader...
Ischemic strokes have been implicated as a cause of death in Chagas disease patients. Inflammation has recognized key component all ischemic processes, including the intravascular events triggered by vessel interruption, brain damage and repair. In this study, we evaluated association between inflammatory markers risk (DR) stroke (SR) patients with different clinical forms chronic disease. The mRNA expression levels cytokines, transcription factors expressed adaptive immune response (Th1,...
Vector transmission of Trypanosoma cruzi occurs in several areas Brazil, including the northeastern region, and domestic animals can serve as reservoirs parasite. The aim this study was to monitor dogs for infection by T. cruzi, main triatomine species involved parasite rural municipalities State Rio Grande do Norte, northeastern, Brazil. Blood samples from (n = 40) manual capture were performed domiciliary peridomiciliary environments towns Acari, Caraúbas Marcelino Vieira, between 2013...
The ecoepidemiological situation in the State of Rio Grande do Norte, Brazil is characterized by frequent invasion and colonization domiciliary units (DUs) several triatomine species, with high rates natural infection Trypanosoma cruzi. METHODS: We evaluated possibility vector transmission T. cruzi based on records occurrence domiciled triatomines collected Secretariat for Public Health from 2005 to 2015. During this period, 67.7% (113/167) municipalities conducted at least one active search...
Chronic chagasic cardiomyopathy (CCC) is observed in 30% to 50% of the individuals infected by Trypanosoma cruzi and heart failure important cause death among patients chronic phase Chagas disease. Although some studies have elucidated role adaptive immune responses involving T B lymphocytes cardiac pathogenesis, innate immunity receptors such as Toll-like (TLRs) Nod-like (NLRs) CCC pathophysiology has not yet been determined. In this study, we evaluated association (TLR1-9...
Resistance or susceptibility to T. cruzi infection is dependent on the host immunological profile. Innate immune receptors, such as Toll-like receptors (TLRs/TLR2, TLR4, TLR7, and TLR9) Nod-like (NLRs/NOD1 NLRP3 inflammasome) are involved with resistance against acute experimental infection. Here, we evaluated impact of virulence expression innate its products in mice. For that, used six strains/isolates that showed low (AM64/TcIV 3253/Tc-V), medium (PL1.10.14/TcIII CL/TcVI), high...
The protozoan Trypanosoma cruzi is the etiologic agent of Chagas disease, an infection that afflicts approximately 8 million people in Latin America. Diagnosis chronic disease currently based on serological tests because this condition usually characterized by high anti-T. IgG titers and low parasitemia. antigens used these assays may have specificity due to cross reactivity with from related parasite infections, such as leishmaniasis, sensitivity caused polymorphism among T. strains....
INTRODUCTION: A seroepidemiological survey was carried out to evaluate Trypanosoma cruzi infection in an endemic area of the State Rio Grande do Norte, Brazil, involving rural residents. METHODS: Sixteen municipalities were randomly selected, 15 from west mesoregion and one central, with estimated population 83,852 individuals. total 1,950 blood samples collected 390 Caicó. Anti-T. antibodies detected using Chagatest® ELISA HAI-hemagglutination kits indirect immunofluorescence. As sera...
Triatomines are responsible for the vector transmission of protozoan parasite Trypanosoma cruzi, which causes Chagas disease. Triatoma brasiliensis is main in Brazil, and dogs an important reservoir parasite. The aim this study was to evaluate insecticidal effect fluralaner (Bravecto®) on T. after a blood meal treated dogs. Healthy mongrel (n = 8) were recruited from Zoonoses Control Center (ZCC) city Natal, Rio Grande do Norte, randomized into two groups, (Bravecto®)-treated group 4)...
This study evaluated the clinical forms and manifestation severities of Chagas disease among serologically reactive individuals from Western Rio Grande do Norte (Northeastern Brazil).This cross-sectional included 186 adults who were using electrocardiography, echocardiography, chest radiography, contrast radiography esophagus colon. A clinical-epidemiological questionnaire was also used.The indeterminate, cardiac, digestive, cardiodigestive diagnosed in 51.6% (96/186), 32.2% (60/186), 8.1%...
Oral infection by Trypanosoma cruzi is currently the most important route of transmission acute Chagas disease (ACD) in North region Brazil, and reported outbreaks are usually related to ingestion contaminated food, especially unprocessed açaí pulp.A retrospective cohort study was performed analyze epidemiological profile individuals with suspected cases ACD municipality Breves, located state Pará, Brazil. Therefore, notifications were collected from Municipal Health Department Breves...
Abstract Objective To evaluate the potential involvement of anti‐ T rypanosoma cruzi and cardiac protein antibody ( I gG total isotypes) production their possible association with different clinical forms human chronic C hagas disease. Methods IgG isotypes were measured by ELISA , using epimastigote trypomastigote . as antigens proteins (myosin troponin ) in sera patients indeterminate IND n = 72), CARD 47) digestive/cardiodigestive DIG / ‐ 12) Samples from uninfected health individuals CONT...
Abstract Background Leishmania infantum is the etiological agent of visceral leishmaniasis (VL) in New World, where sand fly Lutzomyia longipalpis and domestic dogs are considered main vector host reservoirs, respectively. Systemic insecticides have been studied as an alternative to control vector-borne diseases, including VL. Fluralaner, isoxazoline class compound, a systemic insecticide used dogs, with proven efficiency against different species phlebotomine flies. However, date no studies...
Abstract Background Chagas disease (CD), a neglected parasitic caused by Trypanosoma cruzi , poses significant health threat in Latin America and has emerged globally because of human migration. infects humans over 100 other mammalian species, including dogs, which are important sentinels for assessing the risk infection. Nonetheless, serodiagnosis T. dogs is still impaired absence commercial tests. In this study, we investigated diagnostic accuracy four chimeric recombinant IBMP antigens...
We report the first known occurrence of Psammolestes tertius Lent & Jurberg, 1965 (Hemiptera, Reduviidae, Triatominae) in state Rio Grande do Norte, Brazil. In 2009 and 2017, 2 adult specimens, a female male respectively, were collected at Seridó Ecological Station, which is located municipality Serra Negra Norte. These records broadens geographical distribution P. Brazil biodiversity triatomines