A5057145276- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Venomous Animal Envenomation and Studies
- Toxin Mechanisms and Immunotoxins
- Ion channel regulation and function
- Healthcare and Venom Research
- Nanoparticle-Based Drug Delivery
- vaccines and immunoinformatics approaches
- Rabies epidemiology and control
- Insect and Pesticide Research
- Pain Mechanisms and Treatments
- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Laser Applications in Dentistry and Medicine
- Wound Healing and Treatments
- Marine Invertebrate Physiology and Ecology
- Bee Products Chemical Analysis
- Nicotinic Acetylcholine Receptors Study
- Parasitic infections in humans and animals
- Mycotoxins in Agriculture and Food
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Monoclonal and Polyclonal Antibodies Research
- Leprosy Research and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- SARS-CoV-2 and COVID-19 Research
Universidade do Extremo Sul Catarinense
2016-2025
Universidade Federal do Paraná
2020-2025
Centro Universitário do Espírito Santo
2016-2024
Universidade Federal de Santa Catarina
2023
Universidade do Sul de Santa Catarina
2017-2023
Catholic University of Santa María
2022-2023
Universidade Federal de Minas Gerais
2008-2020
Fundação Hospitalar do Estado de Minas Gerais
2020
Benemérita Universidad Autónoma de Puebla
2000-2013
Companhia Energética de Minas Gerais (Brazil)
2004-2005
Scorpionism is a public health problem in Brazil, and Tityus serrulatus (Ts) primarily responsible for severe accidents. The main toxic components of Ts venom are low-molecular-weight neurotoxins; however, the also contains poorly characterized high-molecular-weight enzymes. Hyaluronidase one such enzyme that has been characterized.We examined clones from cDNA library gland described two novel isoforms hyaluronidase, TsHyal-1 TsHyal-2. 83% identical, alignment their predicted amino acid...
Abstract Leishmaniases are neglected diseases caused by infection with Leishmania parasites and there currently no prophylactic vaccines. In this study, we designed in silico a synthetic recombinant vaccine against visceral leishmaniasis (VL) called ChimeraT, which contains specific T-cell epitopes from Prohibitin, Eukaryotic Initiation Factor 5a the hypothetical LiHyp1 LiHyp2 proteins. Subcutaneous delivery of ChimeraT plus saponin stimulated Th1 cell-mediated immune response protected mice...
Apical membrane antigen 1 (AMA-1) is considered to be a major candidate for malaria vaccine. Previous immunoepidemiological studies of naturally acquired immunity Plasmodium vivax AMA-1 (PvAMA-1) have shown higher prevalence specific antibodies domain II (DII) AMA-1. In the present study, we confirmed that antibody responses from infected individuals were highly reactive both full-length and DII. Also, demonstrated strong association between DII IgG subclass responses. We analyzed primary...
Fibromyalgia is a disease characterised as generalised chronic primary pain that causes functional disability and reduction in patients' quality of life, without specific pathophysiology or appropriate treatment. Previous studies have shown kinins their B1 B2 receptors contribute to painful conditions. Thus, we investigated the involvement fibromyalgia-like model induced by reserpine mice. Nociceptive parameters (mechanical allodynia, cold sensitivity overt nociception) behaviours burrowing,...
Background Envenoming by coral snakes (Elapidae: Micrurus), although not abundant, represent a serious health threat in the Americas, especially because antivenoms are scarce. The development of adequate amounts antielapidic serum for treatment accidents caused like Micrurus corallinus is challenging task due to characteristics such as low venom yield, fossorial habit, relatively small sizes and ophiophagous diet. These features make it difficult capture keep these captivity collection....
Healing is the process responsible for restoring integrity of body's internal or external structures when they rupture. Photobiomodulation (PBM) stands out as one most efficient resources in treatment epithelial lesions, well hyaluronic acid (HA), which has been emerging a new molecule dermal and epidermal lesions. The biological application gold nanoparticles (GNPs) shows promising results. This study aimed to investigate possible anti-inflammatory antioxidant effects association between...
Fibromyalgia is characterised mainly by symptoms of chronic widespread pain and comorbidities like depression. Although these cause a notable impact on the patient's quality life, underlying aetiology pathophysiology this disease remain incompletely elucidated. The transient receptor potential vanilloid type 1 (TRPV1) polymodal that involved in development nociceptive depressive behaviours, while α-spinasterol, multitarget TRPV1 antagonist cyclooxygenase inhibitor, presents antinociceptive...
Currently, there is no licensed vaccine to protect against human visceral leishmaniasis (VL), a potentially fatal disease caused by infection with Leishmania parasites. In the current study, recombinant chimeric protein ChimT was developed based on T-cell epitopes identified from immunogenic amastigote proteins LiHyp1, LiHyV, LiHyC and LiHyG. associated adjuvants saponin (Sap) or monophosphoryl lipid A (MPLA) used immunize mice, their immunogenicity protective efficacy were evaluated. Both...
Leishmaniasis, a neglected tropical disease caused by Leishmania species, presents serious public health challenges due to limited treatment options, toxicity, high costs, and drug resistance. In this study, the in vitro potential of malvidin echioidinin is examined as antileishmanial agents against L. amazonensis, braziliensis, infantum, comparing their effects amphotericin B (AmpB), standard drug. Malvidin demonstrated greater potency than across all parasite stages species. Against...
Muscle injuries are frequent in sports, necessitating therapies that reduce inflammation and enhance repair. Platelet-rich plasma (PRP), derived from autologous blood, offers high concentrations of platelets growth factors for tissue regeneration. Interleukin-1 beta (IL-1β), a pro-inflammatory cytokine, is crucial inflammation, its inhibition may speed up healing, but the cost blockers limits their use. This study evaluated effects leukocyte-rich PRP (LR-PRP), leukocyte-poor (LP-PRP),...