A5044855159- Venomous Animal Envenomation and Studies
- Ion channel regulation and function
- Healthcare and Venom Research
- Rabies epidemiology and control
- Insect and Pesticide Research
- Toxin Mechanisms and Immunotoxins
- Marine Invertebrate Physiology and Ecology
- Nicotinic Acetylcholine Receptors Study
- Biochemical and Structural Characterization
- Antimicrobial Peptides and Activities
- vaccines and immunoinformatics approaches
- Mosquito-borne diseases and control
- Research on Leishmaniasis Studies
- Leech Biology and Applications
- Malaria Research and Control
- Bacillus and Francisella bacterial research
- Cellular transport and secretion
- Monoclonal and Polyclonal Antibodies Research
- Amphibian and Reptile Biology
- Bioactive Natural Diterpenoids Research
- Pain Mechanisms and Treatments
- Trypanosoma species research and implications
- Beetle Biology and Toxicology Studies
- Wound Healing and Treatments
- Lipid Membrane Structure and Behavior
Universidade Federal de Minas Gerais
2016-2025
Instituto Nacional de Salud
2020-2022
Centro Universitário de Belo Horizonte
2021
Universidade de Ribeirão Preto
2021
Universidade de São Paulo
2021
Ezequiel Dias Foundation
1994-2020
National University of San Marcos
2020
Fundação Oswaldo Cruz
2020
Centro de Excelência em Bioinformática
2019
Instituto de Ciencias Tecnológicas
2016
Abstract Snake venom L-amino acid oxidases (LAAOs) are flavoproteins, which perform diverse biological activities in the victim such as edema, myotoxicity and cytotoxicity, contributing to development of clinical symptoms envenomation. LAAO cytotoxicity has been described, but temporal cascade events leading cell death not explored so far. This study evaluates involvement dermonecrosis mice its cytotoxic effects normal human keratinocytes, major type epidermis, a tissue that undergoes...
Scorpionism is a public health problem in Brazil, and Tityus serrulatus (Ts) primarily responsible for severe accidents. The main toxic components of Ts venom are low-molecular-weight neurotoxins; however, the also contains poorly characterized high-molecular-weight enzymes. Hyaluronidase one such enzyme that has been characterized.We examined clones from cDNA library gland described two novel isoforms hyaluronidase, TsHyal-1 TsHyal-2. 83% identical, alignment their predicted amino acid...
Tityus serrulatus is a Brazilian scorpion species with great medical significance. While the effects of neurotoxins have been extensively studied, little known about proteases expressed in venom gland this arthropod. In study, clones from T. (Ts) cDNA library were selected according to homology proteases. The sequences aligned database and classified by homology. Similarity identity analyses carried out, phylogenetic tree was constructed other These correspond ten different metalloproteases,...
Annually, more than 1.2 million scorpion stings and 3,000 deaths occur worldwide. Tityus serrulatus Lutz Mello, 1922 (Scorpiones, Buthidae) is the most medically relevant species in Brazil where it spreading rapidly causing over 90,000 cases of envenomation yearly. We monitored T. longevity ability to reproduce under conditions food and/or water deprivation. found that highly tolerant deprivation, with individuals enduring up 400 days without food. On other hand, access played a pivotal role...
Apical membrane antigen 1 (AMA-1) is considered to be a major candidate for malaria vaccine. Previous immunoepidemiological studies of naturally acquired immunity Plasmodium vivax AMA-1 (PvAMA-1) have shown higher prevalence specific antibodies domain II (DII) AMA-1. In the present study, we confirmed that antibody responses from infected individuals were highly reactive both full-length and DII. Also, demonstrated strong association between DII IgG subclass responses. We analyzed primary...
Background Envenoming by coral snakes (Elapidae: Micrurus), although not abundant, represent a serious health threat in the Americas, especially because antivenoms are scarce. The development of adequate amounts antielapidic serum for treatment accidents caused like Micrurus corallinus is challenging task due to characteristics such as low venom yield, fossorial habit, relatively small sizes and ophiophagous diet. These features make it difficult capture keep these captivity collection....
"Efficacy of Antivenom Therapy for Neutralizing Circulating Venom Antigens in Patients Stung by Tityus Serrulatus Scorpions" published on Mar 1995 The American Society Tropical Medicine and Hygiene.
The aims of this study were to devise a process for raising antibodies against Brazilian Bothrops venom in chicken egg yolks, determine the best delipidation method preparation aqueous extract and define purification conditions IgY bothropic antivenom produced eggs from hens immunized with standard antigen. A group nine Single Comb White Leghorn laying five different species pit vipers genus Bothrops. immunization was carried out three cycles, each performed six weeks apart. For extraction,...
A chimeric protein was constructed expressing three epitopes of LiD1, a dermonecrotic toxin from the venom Loxosceles intermedia spider. This species is responsible for large number accidents involving spiders in Brazil. We demonstrated that (rCpLi) generated atoxic and antibodies previously developed rabbits against synthetic reactive with rCpLi ELISA immunoblot assays. The antibody response evaluated by we have detected an all immunized animals. Overlapping peptides covering amino acid...