A5034451855- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parasites and Host Interactions
- vaccines and immunoinformatics approaches
- Synthesis and Biological Evaluation
- Toxin Mechanisms and Immunotoxins
- Science and Education Research
- Chemistry Education and Research
- Education and Digital Technologies
- Nanotechnology research and applications
- Health Education and Validation
Universidade Federal de Ouro Preto
2022-2024
Visceral leishmaniasis (VL) in the Americas is a chronic systemic disease caused by infection with
Abstract Visceral leishmaniasis (VL) is a tropical disease that can be fatal if acute and untreated. Diagnosis difficult, the treatment toxic prophylactic vaccines do not exist. Leishmania parasites express hundreds of proteins several them are relevant for host's immune system. In this context, in present study, 10 specific T-cell epitopes from 5 parasite proteins, which were identified by antibodies VL patients’ sera, selected used to construct gene codifying new chimeric protein called...
The spleen plays a central role in human and canine visceral leishmaniasis, where the activation of immune response occurs one tissues Leishmania infantum reproduces. Therefore, this organ is both target to understand mechanisms involved parasite control parameter for assessing therapeutic response. In sense, study aimed evaluate main histological, immunological parasitological aspects symptomatic dogs naturally infected by L. treated with vaccine LBMPL. For this, were divided into four...