A5060130643- Cerebrovascular and Carotid Artery Diseases
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Cardiac Imaging and Diagnostics
- Nanoparticle-Based Drug Delivery
- Vitamin D Research Studies
- Cardiac tumors and thrombi
- Vitamin K Research Studies
- Developmental Biology and Gene Regulation
- Neuroscience and Neuropharmacology Research
- Acute Ischemic Stroke Management
- Cellular Mechanics and Interactions
- Glioma Diagnosis and Treatment
- dental development and anomalies
- Immune cells in cancer
- Receptor Mechanisms and Signaling
- DNA Repair Mechanisms
- Chemical Synthesis and Analysis
- Nanoplatforms for cancer theranostics
- Parathyroid Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- PARP inhibition in cancer therapy
- Pharmacological Receptor Mechanisms and Effects
Maastricht University Medical Centre
2020-2025
Universitätsklinikum Aachen
2020-2025
RWTH Aachen University
2020-2025
Maastricht University
2020-2024
University Medical Center
2024
Klinik und Poliklinik für Nuklearmedizin
2020-2022
University of Toronto
2019-2020
Ted Rogers Centre for Heart Research
2019-2020
Carol Davila University of Medicine and Pharmacy
2015-2020
Institutul National Victor Babes
2015
Peptide receptor radionuclide therapy is used to treat solid tumors by locally delivering radiation. However, due nephro- and hepato-toxicity, it limited its dosage. To amplify radiation damage tumor cells, radiolabeled nanogels can be used. We show that tuning the mechanical properties of significant enhancement in circulation half-life gel could achieved. demonstrate why how small changes influence cellular fate. Nanogels with a storage modulus 37 kPa were minimally phagocytosed monocytes...
Abstract Introduction Overexpression of prostate-specific membrane antigen (PSMA) on the vasculature triple-negative breast cancer (TNBC) presents a promising avenue for targeted endogenous radiotherapy with [ 177 Lu]Lu-PSMA-I&T. This study aimed to assess and compare therapeutic efficacy single dose fractionated Lu]Lu-PSMA-I&T in an orthotopic model TNBC. Methods Rj:NMRI- Foxn1 nu/nu mice were used as recipients MDA-MB-231 xenografts. The group was treated 1 × 60 ± 5 MBq...
Abstract Purpose In addition to rodent models, the chick embryo model has gained attention for radiotracer evaluation. Previous studies have investigated tumours on chorioallantoic membrane (CAM), but its value imaging of intracerebral yet be demonstrated. Procedures Human U87 glioblastoma cells and U87-IDH1 mutant glioma were implanted into brains embryos at developmental day 5. After 12–14 days tumour growth, blood–brain-barrier integrity was evaluated in vivo using MRI contrast...
As the main inhibitory neurotransmission system, GABAergic system poses an interesting yet underutilized target for molecular brain imaging. While PET imaging of postsynaptic neurons has been accomplished using radiolabeled benzodiazepines targeting GABAA receptor, development presynaptic radioligands GABA transporter 1 (GAT1) unsuccessful thus far. Therefore, we developed a novel GAT1-addressing radioligand and investigated its applicability as tracer in rodents. We selected lipophilic...
The structural process of bone and periodontal ligament (PDL) remodeling during long-term orthodontic tooth movement (OTM) has not been satisfactorily described yet. Although the mechanism changes in directly affected alveolar deeply investigated, detailed knowledge about specific PDL its interaction with OTM is missing. This work aims to provide an accurate user-independent analysis following a prolonged treatment mice. Orthodontic forces were applied using Ni-Ti coil-spring split-mouth...
The diagnostic algorithm for the demyelinating disorders of central nervous system remains a work in progress, with search ideal biomarkers ongoing. so-called “ideal” biomarker should ensure accurate differentiation between most common pathologies CNS and subtypes same pathology (for example, conversion from relapsing–remitting multiple sclerosis to secondary progressive phenotype). Advances technology facilitated this research following sections we will comprehensively review these,...
Abstract Heterozygous missense HTRA1 mutations have been associated with an autosomal dominant cerebral small vessel disease (CSVD) whereas the pathogenicity of heterozygous stop codon variants is unclear. We performed a targeted high throughput sequencing all known CSVD genes, including HTRA1, in 3853 unrelated consecutive patients referred for molecular diagnosis. The frequency leading to premature this patient cohort was compared their large control databases. An analysis mRNA several...
Triple-negative breast cancer (TNBC) lacks biomarkers for targeted therapy. Auger emitters display the best therapeutic effect, if delivered directly into nucleus proximal to DNA. The nuclear protein Poly (ADP-ribose)-Polymerase 1 (PARP1) is a suitable target against which few inhibitors (PARPi) are clinically approved treatment of with germline BRCA mutation (BRCAmut). In this study, theranostic approach was investigated in TNBC xenografted mouse model by radiolabelling close derivative...
Identification and selectivity of molecular targets with prolonged action for difficult-to-target cancer such as triple-negative breast (TNBC) represent a persisting challenge in the precision delivery therapeutics. In quest to target undruggable sites, this study validates bioavailability polydopamine-sealed mesoporous silica nanocarriers (PDA-mSiO2) vivo drug TNBC. For controlled transport release, chemotherapeutic doxorubicin was encapsulated mSiO2 coated PDA layer serving...
Given the high sensitivity and specificity of sodium [18F]Fluoride (Na[18F]F) for vascular calcifications positive emerging data vitamin K on health, aim this study is to assess ability Na[18F]F monitor therapy disease progression in a unitary atherosclerotic mouse model. ApoE-/- mice were placed Western-type diet 12-weeks then split into four groups. The early stage atherosclerosis group received chow an additional 12-weeks, while advanced continued diet. Menaquinone-7 (MK-7) Warfarin...
There is a strong drive worldwide to discover and exploit the therapeutic potential of large variety plants. In this work, an alcoholic extract Helleborus purpurascens (family Ranunculaceae) was investigated for identification amino acids peptides with putative antiproliferative effects. our separation strategy developed using solvents different polarity in order obtain active compounds. Biochemical components were characterized through spectroscopic (mass spectroscopy) chromatographic...
Despite recent medical advances, cardiovascular disease remains the leading cause of death worldwide. As (micro)-calcification is a hallmark atherosclerosis, this review will elaborately discuss advantages sodium fluoride positron emission tomography (PET) as reliable imaging technique for identifying early onset vascular calcification (i.e. locking onto target). We assess state-of-the-art meta-analysis and clinical studies possible treatment options evaluate concept vitamin K...
Abstract Peptide receptor radionuclide therapy is used to treat solid tumors by locally delivering radiation. However, due nephro‐ and hepato‐toxicity, it limited its dosage. To amplify radiation damage tumor cells, radiolabeled nanogels can be used. We show that tuning the mechanical properties of significant enhancement in circulation half‐life gel could achieved. demonstrate why how small changes influence cellular fate. Nanogels with a storage modulus 37 kPa were minimally phagocytosed...
The cellular and molecular mechanisms of orthodontic tooth movement (OTM) are not yet fully understood, partly due to the lack dynamical datasets within same subject. Inflammation calcification two main processes during OTM. Given high sensitivity specificity [68Ga]Ga-Pentixafor Sodium [18F]Fluoride (Na[18F]F) for inflammation calcification, respectively, aim this study is assess their ability identify monitor dynamics OTM in an established mouse model. To real time, animals were scanned...
Small Src homology domain 2 (SH2) and 3 (SH3) adapter proteins regulate cell fate behavior by mediating interactions between surface receptors downstream signaling effectors in many signal transduction pathways. The CT10 regulator of kinase (Crk) family has tissue-specific roles phagocytosis, migration, neuronal development mediates oncogenic pathways like that Abelson kinase. However, redundancy among the two mammalian members position Drosophila gene on fourth chromosome precluded...
[18 F]FTC-146 was introduced as a very potent and selective sigma-1 receptor radioligand, which has shown promising application an imaging agent for neuropathic pain with positron emission tomography. In line multi-laboratory project on animal welfare, we chose this radioligand to investigate its potential detecting tissue damage in tumor-bearing animals. However, the radiochemical yield (RCY) of around 4-7% not satisfactory us, efforts were made improve it. Herein, describe improved...
INTRICATE is a prospective double-blind placebo-controlled feasibility study, assessing the influence of combined vitamin K2 and D3 supplementation on micro-calcification in carotid artery disease as imaged by hybrid Sodium [18F]Fluoride (Na[18F]F) positron emission tomography (PET)/ magnetic resonance imaging (MRI). Arterial calcification an actively regulated process results from imbalance between promoting inhibiting factors. Considering recent advancements medical imaging, ultrasound...
Small animal Positron Emission Tomography (PET) and Single Photon Computed (SPECT) imaging techniques are crucial in preclinical cancer research, necessitating meticulous attention to radiotracer synthesis, quality assurance, vivo injection protocols. This study presents a comprehensive workflow tailored enhance the robustness reproducibility of small PET experiments. The synthesis process radiochemistry laboratory using
<title>Abstract</title> <bold>Purpose:</bold> In addition to rodent models, the chick embryo model has gained attention for radiotracer evaluation. Previous studies investigated tumours on chorioallantoic membrane (CAM), but its value imaging of intracerebral not yet been demonstrated. <bold>Procedures:</bold> Human U87 glioblastoma cells and U87-IDH1 mutant glioma were implanted into brains embryos at developmental day 5. After 12-14 days tumour growth, blood-brain-barrier integrity was...