A5056005463- Carbon dioxide utilization in catalysis
- Catalytic Cross-Coupling Reactions
- Advanced Synthetic Organic Chemistry
- Coordination Chemistry and Organometallics
- Pharmacological Receptor Mechanisms and Effects
- Nanomaterials for catalytic reactions
- Catalysis for Biomass Conversion
- Asymmetric Hydrogenation and Catalysis
- Crystallography and molecular interactions
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
RWTH Aachen University
2021-2023
Abstract A one‐pot, three‐step protocol for the preparation of Grignard reagents from organobromides in a ball mill and their subsequent reactions with gaseous carbon dioxide (CO 2 ) or sodium methyl carbonate providing aryl alkyl carboxylic acids up to 82 % yield is reported. Noteworthy are short reaction times significantly reduced solvent amounts [2.0 equiv. liquid assisted grinding (LAG) conditions]. Unexpectedly, bromides methoxy substituents lead symmetric ketones as major products.
Abstract A one‐pot, three‐step protocol for the preparation of Grignard reagents from organobromides in a ball mill and their subsequent reactions with gaseous carbon dioxide (CO 2 ) or sodium methyl carbonate providing aryl alkyl carboxylic acids up to 82 % yield is reported. Noteworthy are short reaction times significantly reduced solvent amounts [2.0 equiv. liquid assisted grinding (LAG) conditions]. Unexpectedly, bromides methoxy substituents lead symmetric ketones as major products.
Abstract In spite of numerous kinetic studies, the mechanism polyol hydrogenolysis on a Ru catalyst surface is still not fully understood. Here, decomposition C 1 alcohol methanol can serve as an entry to clarification mechanism. Therefore, experiments using Ru/C and periodic DFT calculations Ru(0001) model were performed. A modeling revealed that most likely covered with hydrogen adsorbates under experimental conditions. On clean surface, overall activation barrier lower if less...
[18 F]FTC-146 was introduced as a very potent and selective sigma-1 receptor radioligand, which has shown promising application an imaging agent for neuropathic pain with positron emission tomography. In line multi-laboratory project on animal welfare, we chose this radioligand to investigate its potential detecting tissue damage in tumor-bearing animals. However, the radiochemical yield (RCY) of around 4-7% not satisfactory us, efforts were made improve it. Herein, describe improved...
Grignard reactions invert the intrinsic electrophilic reactivity of organohalides to form C–C bonds with other electrophiles. With carbon dioxide (CO2) as electrophile carboxylic acids can be prepared. Although scattered examples mechanochemical CO2 have been reported, its synthetic application C1-synthon has remained underexplored. Here, we developed a one-pot three-step protocol for preparation reagents from organobromides in ball mill and their subsequent reaction gaseous or sodium methyl...
Grignard reactions invert the intrinsic electrophilic reactivity of organohalides to form C–C bonds with other electrophiles. With carbon dioxide (CO2) as electrophile carboxylic acids can be prepared. Although scattered examples mechanochemical CO2 have been reported, its synthetic application C1-synthon has remained underexplored. Here, we developed a one-pot three-step protocol for preparation reagents from organobromides in ball mill and their subsequent reaction gaseous or sodium methyl...