A5039735249- Orthodontics and Dentofacial Orthopedics
- dental development and anomalies
- Oral microbiology and periodontitis research
- Periodontal Regeneration and Treatments
- Temporomandibular Joint Disorders
- Mesenchymal stem cell research
- Dental materials and restorations
- Dental Radiography and Imaging
- Dental Implant Techniques and Outcomes
- Immune Response and Inflammation
- Bone and Dental Protein Studies
- Coronary Interventions and Diagnostics
- Bone Metabolism and Diseases
- Dental Anxiety and Anesthesia Techniques
- Cleft Lip and Palate Research
- Connective tissue disorders research
- Monoclonal and Polyclonal Antibodies Research
- Osteoarthritis Treatment and Mechanisms
- S100 Proteins and Annexins
- Estrogen and related hormone effects
- Cardiac and Coronary Surgery Techniques
- Advanced Glycation End Products research
- Dental Health and Care Utilization
- Molecular Biology Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
Universitätsklinikum Aachen
2018-2025
RWTH Aachen University
1985-2025
Medtronic (United States)
2000-2022
Düsseldorf University Hospital
2020
Heinrich Heine University Düsseldorf
2020
RELX Group (United States)
2020
Jena University Hospital
2019
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2018
National Institutes of Health
2018
University of Bonn
2012-2017
Patients with chronic kidney disease (CKD) show a high risk of cardiovascular diseases, predominantly caused by accelerated vascular calcification. Vascular calcification is highly regulated process no current treatment. The vasoconstriction-inhibiting factor (VIF) peptide was recently discovered vasoregulatory properties, but information regarding has been described. In the present work, inhibitory effect VIF analysed in vitro smooth muscle cells (VSMCs), ex vivo rat aortic rings, as well...
Abstract Endovascular treatment of intracranial aneurysms with endoluminal flow diverters (single or multiple) has proven to be clinically safe and effective, but is associated a risk thromboembolic complications. Recently, novel biomimetic surface modification covalently bound phosphorylcholine (Shield Technology™) shown reduce the material thrombogenicity Pipeline diverter. Thrombogenicity Flex, Shield, Flow Redirection Endoluminal Device (FRED) in presence human blood under physiological...
Rapid vascularization is required for the regeneration of dental pulp due to spatially restricted tooth environment. Extracellular vesicles (EVs) released from mesenchymal stromal cells show potent proangiogenic effects. Since EVs suffer rapid clearance and low accumulation in target tissues, an injectable delivery system capable maintaining a therapeutic dose over longer period would be desirable. We fabricated EV-fibrin gel composite as situ forming system. were isolated stem (DPSCs)....
Dur3 encodes the yeast plasma membrane urea transporter and Deltadur3 mutants are unable to grow on media containing low concentrations of as sole nitrogen source. Complementation mutant line with expression libraries generated from whole Arabidopsis thaliana seedlings or zucchini (Cucurbita pepo L.) vascular tissue yielded numerous lines that had regained capacity Analysis several these revealed mutation was complemented either by delta-TIP (TIP=tonoplast intrinsic protein) gamma-TIP...
Platelets were found to be stimulated by high shear exposure for 5 minutes. Using a new technique, stresses up 255 N/m2 , acting pathophysiological relevant intervals of milliseconds did not elicit active release β -TG, beyond the amo
Flow diversion is a disruptive technology for the treatment of intracranial aneurysms. However, these intraluminal devices pose risk thromboembolic complications despite dual antiplatelet therapy. We report thrombogenic potential following flow measured experimentally in novel human blood in-vitro pulsatile loop model: Pipeline™ Flex Embolization Device (Pipeline), with Shield Technology™ (Pipeline Shield), Derivo (Derivo), and P64 Modulation (P64). Thrombin generation (Mean ± SD; μg/mL) was...
To assess the effectiveness, clinical performance, and potential adverse effects of early anterior crossbite correction through opening bite.The sample consisted 16 consecutive patients (8.0 ± 0.9, range: 6.2-9.3 years) with dental in mixed dentition who were treated posterior bite opening. Patients prospectively followed until a minimum 6 months post-treatment there no drop-outs.In 14 (87.5 per cent), was corrected. Results remained stable without any retention regime. Active treatment...
This study aimed to evaluate the masking efficacy of caries infiltration technique initial lesions (ICL) six years after debonding and single treatment.In 10 adolescents, 74 ICL (ICDAS 2) in teeth were treated by resin (Icon, DMG) at a mean (SD) 1.2 (1.2) months bracket removal. The etching procedure was performed up 3 times. Standardized digital images taken before treatment (T0), seven days (T7) 6 (T2190) treatment. Outcomes included evaluation color differences between carious healthy...
Due to advancing digitalisation, it is of interest develop standardised and reproducible fully automated analysis methods cranial structures in order reduce the workload diagnosis treatment planning generate objectifiable data. The aim this study was train evaluate an algorithm based on deep learning for detection craniofacial landmarks cone-beam computed tomography (CBCT) terms accuracy, speed, reproducibility.A total 931 CBCTs were used algorithm. To test algorithm, 35 located manually by...
Orthodontic forces have been reported to significantly increase nicotine-induced periodontal bone loss. At present, however, it is unknown, which further (side) effects can be expected during orthodontic treatment at a nicotine exposure corresponding that of an average European smoker. 63 male Fischer344 rats were randomized in three consecutive experiments 21 animals each (A/B/C) 3 experimental groups (7 rats, 1/2/3): (A) cone-beam-computed tomography (CBCT); (B) histology/serology; (C)...