A5078777766- Advanced Glycation End Products research
- Cardiovascular Function and Risk Factors
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular and exercise physiology
- Natural Antidiabetic Agents Studies
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Cardiac Imaging and Diagnostics
- Cardiac Fibrosis and Remodeling
- Folate and B Vitamins Research
- Alcohol Consumption and Health Effects
- Cardiovascular Disease and Adiposity
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
- Exercise and Physiological Responses
- Takotsubo Cardiomyopathy and Associated Phenomena
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Trace Elements in Health
- Cardiovascular Effects of Exercise
- GABA and Rice Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolism, Diabetes, and Cancer
- Heart Rate Variability and Autonomic Control
- Microbial metabolism and enzyme function
Hasselt University
2016-2025
Organ Recovery Systems (Belgium)
2024-2025
King's College London
2016
Centro Cardiologico Monzino
2016
Institute of Experimental Cardiology
2016
Imperial College London
2016
University of Florence
2016
The use of doxorubicin (DOX) chemotherapy is restricted due to dose-dependent cardiotoxicity. Pyridoxamine (PM) a vitamin B6 derivative with favorable effects on diverse cardiovascular diseases, suggesting cardioprotective effect DOX-induced nature PM was investigated in rat model Six-week-old female Sprague Dawley rats were treated intravenously 2 mg/kg DOX or saline (CTRL) weekly for eight weeks. Two other groups received via the drinking water next (DOX+PM) (CTRL+PM). Echocardiography,...
Abstract Exercise training is a low cost and safe approach for reducing the risk of cardiovascular disease development. Currently, moderate-intensity (MIT) most preferred exercise type. However, high-intensity interval (HIIT) gaining interest especially among athletes healthy individuals. In this study, we examined cardiac remodeling resulting from MIT HIIT in rats. Healthy male Sprague-Dawley rats were randomly assigned to or 13 weeks. Animals kept sedentary (SED) used as control. Cardiac...
Endurance exercise training is a promising cardioprotective strategy in type 2 diabetes mellitus (T2DM), but the impact of its intensity not clear. We aimed to investigate whether and how isocaloric moderate-intensity (MIT) high-intensity interval (HIIT) could prevent adverse cardiac remodeling dysfunction that develop T2DM rats. Male rats received Western diet (WD) induce underwent sedentary lifestyle (n = 7), MIT 7) or HIIT 8). Insulin resistance was defined as HOMA-IR value. Cardiac...
Abstract Aims Anthracycline-induced cardiotoxicity has high incidence rates and causes significant mortality among cancer survivors. Damage to myocardial tissue leads left ventricular (LV) dilation with systolic dysfunction, typically assessed through echocardiographic measurement of LV ejection fraction (LVEF) volumes. Early detection is crucial for improving patient outcomes. We aimed evaluate progression diagnostic performance different modalities in an animal model. Methods results...
Exercise training is an encouraging approach to treat cardiac dysfunction in type 2 diabetes (T2DM), but the impact of its intensity not understood. We aim investigate whether and, if so, how moderate-intensity (MIT) and high-intensity interval (HIIT) alleviate adverse remodeling rats with T2DM. Male received standard chow (n = 10) or Western diet (WD) induce Hereafter, WD were subjected a 12-week sedentary lifestyle 8), running MIT 7) HIIT 7). Insulin resistance glucose tolerance assessed...
Doxorubicin (DOX) is commonly used in cancer treatment but associated with cardiotoxicity. Pyridoxamine (PM), a vitamin B6 derivative, could be cardioprotectant. This study investigated the effect of PM on DOX cardiotoxicity and antitumor effectiveness. Sprague Dawley rats were treated intravenously (2 mg/kg/week) or saline over eight weeks. Two other groups received via oral intake (1 g/L water bottles) next to saline. Echocardiography was performed after significantly attenuated...
Individuals with type 2 diabetes mellitus (T2DM) are at an increased risk for heart failure, yet preventive cardiac care is suboptimal in this population. Pyridoxamine (PM), a vitamin B
Advanced glycation end products (AGEs) play a key role in the progression of heart failure. Whether treatments limiting AGEs formation would prevent adverse left ventricular remodeling after myocardial infarction (MI) remain unknown. We investigated whether pyridoxamine (PM) could limit cardiac outcome MI. Rats were divided into MI, MI + PM and Sham. Echocardiography hemodynamic parameters used to assess function 8 weeks post-surgery. Total interstitial collagen, collagen I III quantified...
Growing evidence supports the role of advanced glycation end products (AGEs) in development diabetic vascular complications and cardiovascular diseases (CVDs). We have shown that high-molecular-weight AGEs (HMW-AGEs), present our Western diet, impair cardiac function. Whether HMW-AGEs affect function remains unknown. In this study, we aimed to investigate impact chronic exposure on structure. Adult male Sprague Dawley rats were daily injected with or control solution for 6 weeks. animals...
What is the central question of this study? Does acute exposure to high molecular weight advanced glycation end products (HMW-AGEs) alter cardiomyocyte contractile function? main finding and its importance? Ventricular cardiomyocytes display reduced Ca2+ influx, resulting in capacity, after HMW-AGEs, independent activation their receptor. Given that HMW-AGEs are abundantly present our Western diet, a better understanding underlying mechanisms, especially patients already displaying altered...
Background/aims High-molecular-weight advanced glycation end-products (HMW-AGEs) are abundantly present in our Western diet. There is growing evidence reporting that HMW-AGEs contribute to the development of cardiovascular dysfunction vivo, next well-known low-molecular-weight AGEs. The goal study assess ultrastructure and function cardiomyocytes after chronic exposure HMW-AGEs. A better understanding underlying mechanisms essential create new opportunities for further research on specific...
Myocardial infarction (MI) occurs when the coronary blood supply is interrupted. As a consequence, cardiomyocytes are irreversibly damaged and lost. Unfortunately, current therapies for MI unable to prevent progression towards heart failure. renewal rate of minimal, optimal treatment should achieve effective cardiac regeneration, possibly with stem cells transplantation. In that context, our research group identified atrial appendage (CASCs) as new cellular therapy. However, CASCs...
Background: During myocardial infarction (MI), billions of cardiomyocytes are lost. The optimal therapy should effectively replace damaged cardiomyocytes, possibly with stem cells able to engraft and differentiate into adult functional cardiomyocytes. As such, cardiac atrial appendage (CASCs) suitable candidates. However, the presence elevated levels advanced glycation end products (AGEs) in regions where CASCs transplanted may affect their regenerative potential. In this study, we examine...
This study aimed to investigate the phenolic composition, antioxidant capacity, and toxicity of aqueous extracts Calamintha nepeta L. leaves their potential vasorelaxant effects.
Microglia activity can drive excessive synaptic loss during the prodromal phase of Alzheimer’s disease (AD) and is associated with lowered cyclic adenosine monophosphate (cAMP) due to cAMP phosphodiesterase 4B (PDE4B). This study aimed investigate whether long-term inhibition PDE4B by A33 (3 mg/kg/day) prevent synapse its cognitive decline in APPswe/PS1dE9 mice. model characterized a chimeric mouse/human APP Swedish mutation human PSEN1 lacking exon 9 (dE9), both under control mouse prion...
Chronically increased levels of high molecular weight advanced glycation end products (HMW-AGEs) are known to induce cardiovascular dysfunction. Whether an acute increase in HMW-AGE affects vascular function remains unknown. In this study, we examined whether exposure HMW-AGEs disturbs aortic vasomotor function. Aortae were obtained from healthy male rats and acutely pre-treated with organ baths. Aortic relaxation responses cumulative doses acetylcholine (ACh), the presence or absence...
Introduction: Although doxorubicin (DOX) is an efficient anthracycline agent used to treat cancer, it induces cardiotoxicity and mortality in cancer survivors. Cardioprotection inadequate. The vitamin B 6 -derivative pyridoxamine (PM) has shown be cardioprotective diverse cardiac diseases. Whether PM offers cardioprotection after DOX treatment unknown. We hypothesized that limits impairment by reducing fibrosis inflammation. Methods: Female Sprague Dawley rats were weekly treated with 2...
Background. Several studies have shown that advanced glycation end products (AGEs) are associated with adverse cardiac outcome. In context, growing evidence show high molecular weight AGEs (HMW-AGEs) play a role as important the well characterized low (e.g. pentosidine and carboxymethyllysine), chronically but also possibly acutely. Objective. this study, we investigated whether HMW-AGEs acutely alter Ca2+ homeostasis in cardiomyocytes. Methodology. Single cardiomyocytes from left ventricle...
Muscular Dystrophy (MD) is an umbrella term for genetic disorders affecting skeletal and cardiac muscle which arise due to abnormalities in the dystrophin gene.Underlying defects cause metabolic structural cardiomyocytes (CMs) turn become predisposed ectopic cell death fibro-fatty replacement.The Endogenous Cannabinoid System (ECS) a lipid signalling network present cardiovascular system comprises G-protein coupled receptors (CBR1 CBR2), endogenous ligands (anandamide 2-arachidonoylglycerol)...