A5010075467- Cardiovascular and exercise physiology
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Multiple Sclerosis Research Studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Effects of Exercise
- Heart Failure Treatment and Management
- Cardiac Health and Mental Health
- Nutrition and Health in Aging
- Muscle metabolism and nutrition
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Biochemical effects in animals
- Amyotrophic Lateral Sclerosis Research
- Pancreatic function and diabetes
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Stress Responses and Cortisol
- Cardiovascular Disease and Adiposity
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Sclerosis and Related Diseases
- Muscle Physiology and Disorders
- Free Radicals and Antioxidants
- Sports Performance and Training
- Thermoregulation and physiological responses
Hasselt University
2016-2025
Biomedical Research Institute
2015-2024
Ghent University Hospital
2020
Maastricht University Medical Centre
2016-2018
Maastricht University
2017-2018
Antwerp University Hospital
2015-2016
University of Antwerp
2015-2016
Fund for Scientific Research
2016
Abstract Obesity is associated with a disturbed adipose tissue (AT) function characterized by adipocyte hypertrophy, an impaired lipolysis and pro-inflammatory phenotype, which contributes to insulin resistance (IR). We investigated whether AT phenotype in different depots of obese individuals without type 2 diabetes mellitus (T2DM) whole-body IR. Subcutaneous (SC) visceral (V) biopsies from 18 lean, 17 8 T2DM men were collected. was ex vivo measurement basal stimulated (mature adipocytes),...
Introduction Low-to-moderate intensity exercise improves muscle contractile properties and endurance capacity in multiple sclerosis (MS). The impact of high remains unknown. Methods Thirty-four MS patients were randomized into a sedentary control group (SED, n = 11) 2 groups that performed 12 weeks interval (HITR, 12) or continuous cardiovascular training (HCTR, 11), both combination with resistance training. M.vastus lateralis fiber cross sectional area (CSA) proportion,...
Abstract Immune cell accumulation in adipose tissue (AT) is associated with the development of AT inflammation, resulting metabolic dysfunction. Circulating immune patterns may reflect expanding AT. However, data linking human leukocytes blood and lacking. We investigated whether populations are their counterparts subcutaneous (scAT) or visceral (vAT). Flow cytometry was performed on blood, scAT vAT from 16 lean 29 obese men. natural killer (NK)-cells, classical monocytes nonclassical were...
Histidine-containing dipeptides (HCDs) are pleiotropic homeostatic molecules with potent antioxidative and carbonyl quenching properties linked to various inflammatory, metabolic, neurological diseases, as well exercise performance. However, the distribution metabolism of HCDs across tissues species still unclear.Using a sensitive UHPLC-MS/MS approach an optimized quantification method, we performed systematic extensive profiling in mouse, rat, human body (in n = 26, 25, 19 tissues,...
Chronic nonspecific low back pain (CNSLBP) might be associated with increased sensitivity and inflammation. High-intensity interval training (HIIT) has been suggested to reduce outcomes inflammatory markers, but its effects compared moderate-intensity continuous (MICT) remain unclear. This study aimed evaluate the acute of HIIT on markers in persons CNSLBP healthy controls (HCs) determine how these differ from MICT. Twenty twenty HCs were assessed before (PRE) after (POST) a single MICT...
Exercise training is strongly recommended as a therapeutic approach to treat individuals with heart failure. High-intensity exercise modalities still controversial in this population. The study aims preliminary assess the consequences of high-intensity modalities, aerobic interval (HIIT) and progressive high circuit-resistance (CRT), on primarily endothelial function cardiorespiratory fitness, secondly muscle strength physical performance failure patients.This multicentric randomized...
Abstract Aims To develop and validate equations predicting heart rate (HR) at the first second ventilatory thresholds (VTs) an optimized range-adjusted prescription for patients with cardiometabolic disease (CMD). compare their performance against guideline-based exercise intensity domains. Methods results Cross-sectional study involving 2868 CMD from nine countries. HR predictive VTs (VT1, VT2) were developed using multivariate linear regression 975 cycle-ergometer cardiopulmonary tests...
The prevalence of impaired glucose tolerance (IGT) is higher in persons with multiple sclerosis (MS) compared to healthy controls, indicating metabolic deficits that may increase comorbidity. In other populations, IGT can, at least partly, be reversed by intense physical exercise, but this never investigated before MS.To investigate the effect high intensity aerobic and resistance training on skeletal muscle GLUT4 content MS.Thirty-four MS (aged 45 ± 3 years, EDSS 2.5 1.07) were randomized...
Recently, the authors reported an elevated prevalence of impaired glucose tolerance in individuals with multiple sclerosis (MS), compared matched healthy controls, indicating metabolic defects that may increase comorbidity. MS also leads to a more inactive lifestyle, increasing likelihood develop fat accumulation, muscle wasting/weakness, and exercise intolerance. In other populations, these health complications can partly be reversed by physical exercise.The aim this study was determine...
Catecholamines and atrial natriuretic peptide (ANP) are major regulators of adipocyte lipolysis. Although obesity is characterized by catecholamine resistance in subcutaneous adipose tissue (SCAT), data on ANP lipolytic response sensitivity different (AT) depots metabolically distinct humans scarce. Ex vivo catecholamine- ANP-induced lipolysis was investigated adipocytes derived from SCAT visceral AT (VAT) depot lean (n=13) obese men, with (n=11) or without (n=18) type 2 diabetes (HbA1c...
Low physical activity levels in persons with multiple sclerosis (MS) may reduce skeletal muscle oxidative capacity. Rehabilitation strategies might be altered by a measure of capacity that did not require invasive techniques or maximal exercise testing. For this purpose, we measured onset and offset oxygen uptake (Vo(2)) kinetics during endurance exercise.This study compared exercise-onset -offset Vo(2) mildly affected MS healthy matched participants.From 38 patients who had mean Expanded...
The impact of high-intensity exercise on disease progression and muscle contractile properties in experimental autoimmune encephalomyelitis (EAE) remains unclear. Control (CON) EAE rats were divided into sedentary groups. Before onset (experiment 1, n=40) after hindquarter paralysis 2, n=40), isokinetic foot extensor strength, cross sectional area (CSA) tibialis anterior (TA), digitorum longus (EDL) soleus (SOL) brain-derived neurotrophic factor (BDNF) levels assessed. reduced fiber CSA TA,...
ABSTRACT Introduction This study examines the role of nutritional status during exercise training in patients with type 2 diabetes mellitus by investigating effect endurance-type fasted versus fed state on clinical outcome measures, glycemic control, and skeletal muscle characteristics male patients. Methods Twenty-five (glycated hemoglobin (HbA1 c ), 57 ± 3 mmol·mol −1 (7.4% 0.3%)) participated a randomized 12-wk supervised intervention, being performed an overnight-fasted ( n = 13) or...
What is the central question of this study? It remains uncertain whether significant fat-free mass wasting occurs early after coronary artery bypass graft surgery, and aetiology in these particular conditions unexplored. main finding its importance? Significant present effect greater younger patients with increments blood cortisol-to-testosterone ratios surgery. The magnitude muscle (CABG) surgery unknown. In study, we assessed changes CABG explored possible (relationships postsurgical...
Obesity-related adipose tissue (AT) dysfunction, in particular subcutaneous AT (SCAT) lipolysis, is characterized by catecholamine resistance and impaired atrial natriuretic peptide (ANP) responsiveness. It remains unknown whether exercise training improves (non-)adrenergically mediated lipolysis metabolically compromised conditions. We investigated the effects of local combined α-/β-adrenoceptor blockade on abdominal SCAT lean insulin sensitive (IS) (n=10), obese IS resistant (IR) (n=10)...