A5079696781- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Cardiovascular and exercise physiology
- Biochemical effects in animals
- Delphi Technique in Research
- Heart Rate Variability and Autonomic Control
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Asthma and respiratory diseases
- Healthcare and Venom Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nutrition and Health in Aging
- Free Radicals and Antioxidants
- Cerebral Palsy and Movement Disorders
- Exercise and Physiological Responses
- Stress Responses and Cortisol
- Respiratory viral infections research
- Scoliosis diagnosis and treatment
- Health, psychology, and well-being
- Research Data Management Practices
- Expert finding and Q&A systems
- Linguistic Studies and Language Acquisition
- Infections and bacterial resistance
- Medicinal Plants and Bioactive Compounds
- Chemotherapy-induced organ toxicity mitigation
- Balance, Gait, and Falls Prevention
Umeå University
2022-2025
Hasselt University
2016-2024
Ciro
2020-2021
University of California, San Francisco
2020
Harbor–UCLA Medical Center
2020
Maastricht University Medical Centre
2020
Boehringer Ingelheim (United States)
2020
UCLA Medical Center
2020
The Lundquist Institute
2020
Biomedical Research Institute
2020
Histidine-containing dipeptides (HCDs) are pleiotropic homeostatic molecules with potent antioxidative and carbonyl quenching properties linked to various inflammatory, metabolic, neurological diseases, as well exercise performance. However, the distribution metabolism of HCDs across tissues species still unclear.Using a sensitive UHPLC-MS/MS approach an optimized quantification method, we performed systematic extensive profiling in mouse, rat, human body (in n = 26, 25, 19 tissues,...
To determine the response to a pulmonary rehabilitation (PR) program and minimal important differences (MIDs) for Short Physical Performance Battery (SPPB) subtests SPPB summary score in patients with chronic obstructive disease (COPD).Retrospective analysis using distribution- anchor-based methods.PR center Netherlands including comprehensive 40-session 8-week inpatient or 14-week outpatient program.A total of 632 COPD (age, 65±8y; 50% male; forced expiratory volume first second=43%...
Beyond being a pulmonary disease, chronic obstructive disease (COPD) presents with extrapulmonary manifestations including reduced cognitive, cardiovascular, and muscle function. While exercise training is the cornerstone in non-pharmacological treatment of COPD, there need for new methods due to suboptimal adaptations when following traditional guidelines, often applying moderate-intensity continuous (MICT). In people short-duration high-intensity interval (HIIT) holds potential induce more...
Abstract: Chronic low-grade systemic inflammation is frequently observed in patients with chronic obstructive pulmonary disease (COPD), e.g., elevated pentameric CRP (pCRP). However, pCRP can dissociate to form monomeric (mCRP) which exhibits a clear pro-inflammatory behaviour contrast the more anti-inflammatory properties of pCRP. Therefore, mCRP may be an informative biomarker demonstrate inflammation. This was confirmed by analysing serum samples from 38 COPD and 18 non-COPD control...
Abstract Histidine-containing dipeptides (HCDs) are pleiotropic homeostatic molecules linked to inflammatory, metabolic and neurological diseases, as well exercise performance. Using a sensitive UHPLC-MS/MS approach an optimized quantification method, we performed systematic extensive profiling of HCDs in the mouse, rat, human body (in n=26, n=25, n=19 tissues, respectively). Our data show that tissue HCD levels uniquely regulated by carnosine synthase (CARNS1), enzyme was preferentially...
Patients with abdominal rectus diastasis (ARD) may have muscular functional impairments, but clinics lack appropriate objective assessment tools. The aim was to establish the relative and absolute reliability, convergent validity, of activity using Surface Electromyography (SEMG) during isometric muscle strength testing in patients ARD controls without ARD.
Oxidative/carbonyl stress is elevated in lower-limb muscles of patients with chronic obstructive pulmonary disease (COPD). Carnosine a skeletal muscle antioxidant particularly present fast-twitch fibers. The aims the study were to compare carnosine, oxidative/carbonyl stress, antioxidants, and fiber characteristics between COPD healthy controls (HCs) after stratification for airflow limitation (mild/moderate vs. severe/very severe), as well investigate correlates carnosine COPD. A vastus...
Isokinetic testing of peripheral muscle function is valid and reliable in patients with chronic obstructive pulmonary disease (COPD).To evaluate whether to what extent isokinetic quadriceps meets pre-defined test criteria COPD; determine the response rehabilitation (PR), calculate minimal important differences (MIDs) function.Retrospective analysis 2033 COPD (age: 65±9 years, body mass index: 26±6 kg/m2, FEV1: 49±22% predicted) who followed a comprehensive PR program. Pre post was assessed...
Introduction Exercise intolerance is common in patients with chronic obstructive pulmonary disease (COPD) and, although multifactorial, it largely caused by lower-limb muscle dysfunction. Research has shown that severe to very COPD have significantly lower levels of carnosine, which acts as a pH buffer and antioxidant. Beta-alanine (BA) supplementation been consistently elevate carnosine variety populations may therefore improve exercise tolerance function. The primary objective the current...
The lack of reference values lower-limb muscle function hinders the clinical recommendations its measurement in patients with COPD. Therefore, this study aimed to develop equations predict for quadriceps strength, endurance and power evaluate their construct validity COPD.Quadriceps were assessed 158 healthy individuals 87 In addition, COPD performed a 6-min walk test (6MWT) 1-min sit-to-stand (1STS). Multiple linear regressions equations. proportion reduced was determined, correlations...
High-intensity exercise is essential for optimal development of cardiorespiratory fitness and health. This is, however, challenging most people with chronic obstructive pulmonary disease (COPD) due to ventilatory limitations, leading at lower intensities accompanied by suboptimal stress on the cardiovascular muscular system. PURPOSE: To compare acute effects a novel concept short-duration supramaximal high-intensity interval training (HIIT) vs. moderate-intensity continuous (MICT) in COPD...
Purpose: Pulmonary rehabilitation (PR) is the standard of care for chronic, symptomatic lung disease. Current scientific and clinical guidelines recommend PR to improve dyspnea, functional capacity, quality life. Several provide recommendations about mode, intensity, duration, frequency, progression exercise-based interventions. There are variations in components exercise prescription that may influence response PR, as well how its determined monitored. Therefore, purpose this investigation...